Desmond G. Higgins

146.6k citations

132 papers · 120.5k indexed · 15 hit papers · h-index 56

Molecular Biology top 0.01%
Plant Science top 0.01%
Ecology top 0.01%
Genetics top 0.01%
Infectious Diseases top 0.05%

Co-authors: Toby J. Gibson Julie Thompson Andreas Wilm Hamish McWilliam Rodrigo López Fabian Sievers Paul M. Sharp Cédric Notredame
Topics: Genomics and Phylogenetic Studies (58 papers)RNA and protein synthesis mechanisms (31 papers)Machine Learning in Bioinformatics (19 papers)
Cited by: Molecular Biology Endocrinology Plant Science
Journals: Nature Proceedings of the National Academy of Sciences Nucleic Acids Research
Partner nations: Ireland United States Germany

In The Last Decade

Desmond G. Higgins

131 papers receiving 117.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 56.8k citations Julie Thompson, Desmond G. Higgins et al. Nucleic Acids Research profile →
Clustal W and Clustal X version 2.0

2007 23.8k citations Gordon Blackshields, Nigel P. Brown et al. Bioinformatics profile →
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega

2011 11.2k citations Fabian Sievers, Andreas Wilm et al. profile →
T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. Thornton

2000 5.5k citations Cédric Notredame, Desmond G. Higgins et al. profile →
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 3.0k citations Desmond G. Higgins et al. profile →
Multiple sequence alignment with Clustal X

1998 2.4k citations Julie Thompson, Desmond G. Higgins et al. profile →
Multiple Sequence Alignment Using ClustalW and ClustalX

2002 2.3k citations Julie Thompson, Toby J. Gibson et al. profile →
CLUSTAL V: improved software for multiple sequence alignment

1992 2.2k citations Desmond G. Higgins, Rainer Fuchs et al. profile →
[22] Using CLUSTAL for multiple sequence alignments

1996 1.4k citations Desmond G. Higgins, Julie Thompson et al. profile →
Clustal Omega for making accurate alignments of many protein sequences

2017 1.3k citations Fabian Sievers, Desmond G. Higgins Protein Science profile →
Fast and sensitive multiple sequence alignments on a microcomputer

1989 1.2k citations Desmond G. Higgins et al. profile →
Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences

2013 917 citations Fabian Sievers, Desmond G. Higgins profile →
Clustal Omega

2014 513 citations Fabian Sievers, Desmond G. Higgins profile →
Codon usage patterns inEscherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogasterandHomo sapiens; a review of the considerable within-species diversity

1988 504 citations Desmond G. Higgins et al. Nucleic Acids Research profile →
"Silent" sites in Drosophila genes are not neutral: evidence of selection among synonymous codons.

1988 470 citations Desmond G. Higgins et al. profile →

Peers

Countries citing papers authored by Desmond G. Higgins

Since Specialization

Citations

This map shows the geographic impact of Desmond G. Higgins's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Desmond G. Higgins with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Desmond G. Higgins more than expected).

Fields of papers citing papers by Desmond G. Higgins

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Desmond G. Higgins. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Desmond G. Higgins. The network helps show where Desmond G. Higgins may publish in the future.

Co-authorship network of co-authors of Desmond G. Higgins

This figure shows the co-authorship network connecting the top 25 collaborators of Desmond G. Higgins. A scholar is included among the top collaborators of Desmond G. Higgins based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Desmond G. Higgins. Desmond G. Higgins is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes 2023 ·Scientific Data ·Thomas Schwarzl,(unknown),Georgina Shaw,Aleksandar Krstić,Elizabeth Clayton,Desmond G. Higgins,Walter Kölch,Frank Barry	8
2	QuanTest2: benchmarking multiple sequence alignments using secondary structure prediction 2019 ·Bioinformatics ·Fabian Sievers,Desmond G. Higgins	16
3	Clustal Omega for making accurate alignments of many protein sequencesbreakdown → 2017 ·Protein Science ·Fabian Sievers,Desmond G. Higgins	1271
4	OD-seq: outlier detection in multiple sequence alignments 2015 ·BMC Bioinformatics ·Peter Jehl,Fabian Sievers,Desmond G. Higgins	24
5	Loss of Olfactory Receptor Function in Hominin Evolution 2014 ·PLoS ONE ·Graham M. Hughes,Emma C. Teeling,Desmond G. Higgins	20
6	Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans 2014 ·PLoS Pathogens ·Linda Holland,Markus Schröder,Siobhán A. Turner,Heather Taff,David R. Andes,(unknown),Attila Gácser,Lauren Ames,Ken Haynes,Desmond G. Higgins,Geraldine Butler	94
7	GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling 2013 ·Molecular Cancer Therapeutics ·David J. Duffy,Aleksandar Krstić,Thomas Schwarzl,Desmond G. Higgins,Walter Kölch	71
8	miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro 2012 ·Clinical Cancer Research ·Laoighse Mulrane,Stephen F. Madden,Donal J. Brennan,Gabriela Gremel,Sharon F. McGee,Sara McNally,Finian Martin,John Crown,Karin Jirström,Desmond G. Higgins,William M. Gallagher,Darran P. O’Connor	71
9	Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer 2008 ·Clinical Cancer Research ·Donal J. Brennan,Elton Rexhepaj,Sallyann L. O’Brien,Elaine McSherry,Darran P. O’Connor,Ailís Fagan,Aedín C. Culhane,Desmond G. Higgins,Karin Jirström,Robert C. Millikan,Göran Landberg,Michael J. Duffy,Stephen M. Hewitt,William M. Gallagher	71
10	Hypoxia Selectively Activates the CREB Family of Transcription Factors in the In Vivo Lung 2008 ·American Journal of Respiratory and Critical Care Medicine ·Martin O. Leonard,Katherine B. Howell,Stephen F. Madden,Christine Costello,Desmond G. Higgins,Cormac T. Taylor,Paul McLoughlin	55
11	Clustal W and Clustal X version 2.0breakdown → 2007 ·Bioinformatics ·(unknown),Gordon Blackshields,Nigel P. Brown,Chenna Ramu,Paul McGettigan,Hamish McWilliam,F. Valentin,Iain M. Wallace,Andreas Wilm,Rodrigo López,Julie Thompson,Toby J. Gibson,Desmond G. Higgins	23845
12	Co-regulation of Gremlin and Notch signalling in diabetic nephropathy 2007 ·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·David Walsh,Sarah Roxburgh,Paul McGettigan,Céline C. Berthier,Desmond G. Higgins,Matthias Kretzler,Clemens D. Cohen,Sergio Mezzano,Derek P. Brazil,Finian Martin	95
13	APDB: a novel measure for benchmarking sequencealignment methods without reference alignments 2003 ·Bioinformatics ·Órla O’Sullivan,(unknown),Desmond G. Higgins,Philipp Bücher,Aurélien Grosdidier,Cédric Notredame	40
14	Between-group analysis of microarray data 2002 ·Bioinformatics ·Aedín C. Culhane,Guy Perrière,Elizabeth C. Considine,Thomas G. Cotter,Desmond G. Higgins	189
15	Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach 2000 ·Oxford University Press eBooks ·Desmond G. Higgins,W.R. Taylor	12
16	Amino acid-based phylogeny and alignment 2000 ·Advances in protein chemistry ·Desmond G. Higgins	4
17	MIAH: automatic alignment of eukaryotic SSU rRNAs. 1999 ·Bioinformatics ·(unknown),(unknown),Annette McGrath,Desmond G. Higgins	2
18	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choicebreakdown → 1994 ·Nucleic Acids Research ·Julie Thompson,Desmond G. Higgins,Toby J. Gibson	56835
19	The EMBL data library 1993 ·Nucleic Acids Research ·Catherine M. Rice,Rainer Fuchs,Desmond G. Higgins,Peter Stoehr,Graham Cameron	54
20	Four additions to the Irish spider (Araneae) fauna. 1990 ·Desmond G. Higgins	1

About Desmond G. Higgins

Desmond G. Higgins is a scholar working on Molecular Biology, Hepatology and Cancer Research, having authored 132 papers that have together received 120.5k indexed citations. Recurring topics across this work include Genomics and Phylogenetic Studies (58 papers), RNA and protein synthesis mechanisms (31 papers) and Machine Learning in Bioinformatics (19 papers). The work is most often cited by research in Molecular Biology (67.4k citations), Endocrinology (3.8k citations) and Plant Science (26.7k citations). Desmond G. Higgins has collaborated with scholars based in Ireland, United States and Germany. Frequent co-authors include Toby J. Gibson, Julie Thompson, Andreas Wilm, Hamish McWilliam, Rodrigo López, Fabian Sievers, Paul M. Sharp, Cédric Notredame, Iain M. Wallace and Gordon Blackshields. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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