Desmond G. Higgins

146.6k total citations · 15 hit papers
132 papers, 120.5k citations indexed

About

Desmond G. Higgins is a scholar working on Molecular Biology, Ecology and Genetics. According to data from OpenAlex, Desmond G. Higgins has authored 132 papers receiving a total of 120.5k indexed citations (citations by other indexed papers that have themselves been cited), including 107 papers in Molecular Biology, 11 papers in Ecology and 11 papers in Genetics. Recurrent topics in Desmond G. Higgins's work include Genomics and Phylogenetic Studies (58 papers), RNA and protein synthesis mechanisms (31 papers) and Machine Learning in Bioinformatics (19 papers). Desmond G. Higgins is often cited by papers focused on Genomics and Phylogenetic Studies (58 papers), RNA and protein synthesis mechanisms (31 papers) and Machine Learning in Bioinformatics (19 papers). Desmond G. Higgins collaborates with scholars based in Ireland, United States and Germany. Desmond G. Higgins's co-authors include Toby J. Gibson, Julie Thompson, Andreas Wilm, Hamish McWilliam, Rodrigo López, Fabian Sievers, Paul M. Sharp, Cédric Notredame, Iain M. Wallace and Gordon Blackshields and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Desmond G. Higgins

131 papers receiving 117.4k citations

Hit Papers

CLUSTAL W: improving the sensitivity of progressive multi... 1988 2026 2000 2013 1994 2007 2011 2000 1988 10.0k 20.0k 30.0k 40.0k 50.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    1994 56.8k citations Julie Thompson, Desmond G. Higgins et al. Nucleic Acids Research profile →
  2. Clustal W and Clustal X version 2.0
    2007 23.8k citations Gordon Blackshields, Nigel P. Brown et al. Bioinformatics profile →
  3. Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
    2011 11.2k citations Fabian Sievers, Andreas Wilm et al. Molecular Systems Biology profile →
  4. T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. Thornton
    2000 5.5k citations Cédric Notredame, Desmond G. Higgins et al. profile →
  5. CLUSTAL: a package for performing multiple sequence alignment on a microcomputer
    1988 3.0k citations Desmond G. Higgins et al. profile →
  6. Multiple sequence alignment with Clustal X
    1998 2.4k citations Julie Thompson, Desmond G. Higgins et al. profile →
  7. Multiple Sequence Alignment Using ClustalW and ClustalX
    2002 2.3k citations Julie Thompson, Toby J. Gibson et al. profile →
  8. CLUSTAL V: improved software for multiple sequence alignment
    1992 2.2k citations Desmond G. Higgins et al. profile →
  9. [22] Using CLUSTAL for multiple sequence alignments
    1996 1.4k citations Desmond G. Higgins, Julie Thompson et al. profile →
  10. Clustal Omega for making accurate alignments of many protein sequences
    2017 1.3k citations Fabian Sievers, Desmond G. Higgins Protein Science profile →
  11. Fast and sensitive multiple sequence alignments on a microcomputer
    1989 1.2k citations Desmond G. Higgins et al. profile →
  12. Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences
    2013 917 citations Fabian Sievers, Desmond G. Higgins profile →
  13. Clustal Omega
    2014 513 citations Fabian Sievers, Desmond G. Higgins profile →
  14. Codon usage patterns inEscherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogasterandHomo sapiens; a review of the considerable within-species diversity
    1988 504 citations Desmond G. Higgins, Kenneth H. Wolfe et al. Nucleic Acids Research profile →
  15. "Silent" sites in Drosophila genes are not neutral: evidence of selection among synonymous codons.
    1988 470 citations Desmond G. Higgins et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Desmond G. Higgins Ireland 56 67.4k 26.7k 17.6k 17.1k 8.9k 132 120.5k
Toby J. Gibson Germany 69 65.8k 1.0× 24.7k 0.9× 16.2k 0.9× 16.2k 0.9× 8.2k 0.9× 148 116.5k
David J. Lipman United States 50 66.4k 1.0× 22.8k 0.9× 18.0k 1.0× 15.0k 0.9× 6.8k 0.8× 80 112.8k
Julie Thompson France 38 74.2k 1.1× 34.3k 1.3× 23.6k 1.3× 19.6k 1.2× 9.5k 1.1× 124 138.9k
Stephen F. Altschul United States 42 95.6k 1.4× 34.8k 1.3× 24.4k 1.4× 19.4k 1.1× 7.8k 0.9× 70 156.2k
Peer Bork Germany 151 97.1k 1.4× 18.8k 0.7× 15.9k 0.9× 15.3k 0.9× 7.4k 0.8× 524 145.9k
Steven L. Salzberg United States 96 110.2k 1.6× 46.6k 1.7× 20.8k 1.2× 24.8k 1.5× 7.0k 0.8× 244 185.4k
Joseph Sambrook United States 49 78.4k 1.2× 24.3k 0.9× 13.2k 0.7× 25.9k 1.5× 6.9k 0.8× 339 127.1k
Eugene W. Myers United States 49 50.9k 0.8× 19.4k 0.7× 14.0k 0.8× 11.8k 0.7× 5.1k 0.6× 126 88.6k
Heng Li China 59 68.3k 1.0× 27.2k 1.0× 12.9k 0.7× 35.9k 2.1× 7.3k 0.8× 289 122.6k
Richard Durbin United Kingdom 78 74.7k 1.1× 26.9k 1.0× 12.4k 0.7× 42.8k 2.5× 5.6k 0.6× 169 133.8k

Countries citing papers authored by Desmond G. Higgins

Since Specialization
Citations

This map shows the geographic impact of Desmond G. Higgins's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Desmond G. Higgins with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Desmond G. Higgins more than expected).

Fields of papers citing papers by Desmond G. Higgins

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Desmond G. Higgins. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Desmond G. Higgins. The network helps show where Desmond G. Higgins may publish in the future.

Co-authorship network of co-authors of Desmond G. Higgins

This figure shows the co-authorship network connecting the top 25 collaborators of Desmond G. Higgins. A scholar is included among the top collaborators of Desmond G. Higgins based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Desmond G. Higgins. Desmond G. Higgins is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Schwarzl, Thomas, Georgina Shaw, Aleksandar Krstić, et al.. (2023). Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes. Scientific Data. 10(1). 758–758. 8 indexed citations
2.
Sievers, Fabian & Desmond G. Higgins. (2019). QuanTest2: benchmarking multiple sequence alignments using secondary structure prediction. Bioinformatics. 36(1). 90–95. 16 indexed citations
3.
Holland, Linda, Lisa Lombardi, Aisling Y. Coughlan, et al.. (2018). TPP riboswitch-dependent regulation of an ancient thiamin transporter in Candida. PLoS Genetics. 14(5). e1007429–e1007429. 21 indexed citations
4.
Sievers, Fabian & Desmond G. Higgins. (2017). Clustal Omega for making accurate alignments of many protein sequences. Protein Science. 27(1). 135–145. 1271 indexed citations breakdown →
5.
Hughes, Graham M., Emma C. Teeling, & Desmond G. Higgins. (2014). Loss of Olfactory Receptor Function in Hominin Evolution. PLoS ONE. 9(1). e84714–e84714. 20 indexed citations
6.
Holland, Linda, Markus Schröder, Siobhán A. Turner, et al.. (2014). Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans. PLoS Pathogens. 10(9). e1004365–e1004365. 94 indexed citations
7.
Duffy, David J., Aleksandar Krstić, Thomas Schwarzl, Desmond G. Higgins, & Walter Kölch. (2013). GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling. Molecular Cancer Therapeutics. 13(2). 454–467. 71 indexed citations
8.
Mulrane, Laoighse, Stephen F. Madden, Donal J. Brennan, et al.. (2012). miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro. Clinical Cancer Research. 18(24). 6702–6713. 71 indexed citations
9.
Sievers, Fabian, Andreas Wilm, Toby J. Gibson, et al.. (2011). Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega. Molecular Systems Biology. 7(1). 539–539. 11202 indexed citations breakdown →
10.
Brennan, Donal J., Elton Rexhepaj, Sallyann L. O’Brien, et al.. (2008). Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer. Clinical Cancer Research. 14(9). 2681–2689. 71 indexed citations
11.
Leonard, Martin O., Katherine B. Howell, Stephen F. Madden, et al.. (2008). Hypoxia Selectively Activates the CREB Family of Transcription Factors in the In Vivo Lung. American Journal of Respiratory and Critical Care Medicine. 178(9). 977–983. 55 indexed citations
12.
Walsh, David, Sarah Roxburgh, Paul McGettigan, et al.. (2007). Co-regulation of Gremlin and Notch signalling in diabetic nephropathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1782(1). 10–21. 95 indexed citations
13.
Blackshields, Gordon, Nigel P. Brown, Chenna Ramu, et al.. (2007). Clustal W and Clustal X version 2.0. Bioinformatics. 23(21). 2947–2948. 23845 indexed citations breakdown →
14.
O’Sullivan, Órla, et al.. (2003). APDB: a novel measure for benchmarking sequencealignment methods without reference alignments. Bioinformatics. 19(suppl_1). i215–i221. 40 indexed citations
15.
Higgins, Desmond G. & W.R. Taylor. (2000). Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach. Oxford University Press eBooks. 12 indexed citations
16.
Higgins, Desmond G.. (2000). Amino acid-based phylogeny and alignment. Advances in protein chemistry. 54. 99–135. 4 indexed citations
17.
McGrath, Annette, et al.. (1999). MIAH: automatic alignment of eukaryotic SSU rRNAs.. Bioinformatics. 15(4). 341–342. 2 indexed citations
18.
Thompson, Julie, Desmond G. Higgins, & Toby J. Gibson. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research. 22(22). 4673–4680. 56835 indexed citations breakdown →
19.
Higgins, Desmond G., et al.. (1991). Molecular phylogeny of the subgenus Sophophora of Drosophila derived from large subunit of ribosomal RNA sequences. Genetica. 84(2). 87–94. 54 indexed citations
20.
Higgins, Desmond G.. (1990). Four additions to the Irish spider (Araneae) fauna.. 23(7). 279–280. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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