David N. Sheppard

8.9k citations

107 papers · 6.9k indexed · 2 hit papers · h-index 44

Impact in

Pulmonary and Respiratory Medicine top 0.5%
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
Spectroscopy top 1%
- Molecular Sensors and Ion Detection

Papers in

Pulmonary and Respiratory Medicine 83
- Cystic Fibrosis Research Advances 81
- Neonatal Respiratory Health Research 45
- Tracheal and airway disorders 7
Molecular Biology 59
- Ion channel regulation and function 29
- Advanced biosensing and bioanalysis techniques 22
- Ion Transport and Channel Regulation 12

Co-authors: Michael J. Welsh Zhiwei Cai Anthony P. Davis Hongyu Li Lynda S. Ostedgaard Bradley D. Smith Devra P. Rich Katherine A. Robinson
Journals: The Journal of Physiology (14 papers)Journal of Cystic Fibrosis (12 papers)Journal of Biological Chemistry (9 papers)British Journal of Pharmacology (6 papers)American Journal of Physiology-Lung Cellular and Molecular Physiology (6 papers)
Partner nations: United Kingdom United States Portugal

In The Last Decade

David N. Sheppard

105 papers receiving 6.9k citations

Hit Papers

align trajectories log scale

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations 2016 · 422 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 Molecular Biology of the Cell
1999 Physiological Reviews

Peers

Countries citing papers authored by David N. Sheppard

Since Specialization

Citations

This map shows the geographic impact of David N. Sheppard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David N. Sheppard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David N. Sheppard more than expected).

Fields of papers citing papers by David N. Sheppard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David N. Sheppard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David N. Sheppard. The network helps show where David N. Sheppard may publish in the future.

Co-authors

The 25 scholars most cited alongside David N. Sheppard, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David N. Sheppard Line = papers co-authored together David N. Sheppard links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Managing an ageing cystic fibrosis population: challenges and priorities European Respiratory Review ·Freddy Frost, D. Peckham, I. Felton, J. Snowball, Robert D. Gray, Andrew Jones, Nicholas J. Simmonds, Robert Lord, Gregory Y.H. Lip, (unknown), Kevin P. Murphy, D.G. Downey, David N. Sheppard, Jane C. Davies, John Bull, Paula Sommer, Belinda Cupid, Lucy Allen, J. Duckers	2025	0
2	In vitro platform to model the function of ionocytes in the human airway epithelium Respiratory Research ·Marta Vilà‐González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andrés Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier	2024	5
3	Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor The Journal of Physiology ·Hongyu Li, Mayuree Rodrat, Majid Al-Salmani, Diana‐Florentina Veselu, Sangwoo T. Han, Karen S. Raraigh, Garry R. Cutting, David N. Sheppard	2024	4
4	Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains Journal of Biological Chemistry ·Stella Prins, Valentina Corradi, David N. Sheppard, D. Peter Tieleman, Paola Vergani	2022	7
5	A topological switch in CFTR modulates channel activity and sensitivity to unfolding Nature Chemical Biology ·Daniel Scholl, Maud Sigoillot, Marie Overtus, Rafael Colomer Martinez, Chloé Martens, Yi‐Ting Wang, Els Pardon, Toon Laeremans, Abel García-Pino, Jan Steyaert, David N. Sheppard, Jelle Hendrix, Cédric Govaerts	2021	11
6	A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR British Journal of Pharmacology ·Jia Liu, Allison P. Berg, Yi‐Ting Wang, Walailak Jantarajit, Katy J. Sutcliffe, Edward B. Stevens, Lishuang Cao, Marko J. Pregel, David N. Sheppard	2021	14
7	Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors Journal of Cystic Fibrosis ·Vinciane Saint‐Criq, Yi‐Ting Wang, Livia Delpiano, JinHeng Lin, David N. Sheppard, Michael A. Gray	2021	2
8	Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs Chemical Science ·Hongyu Li, Hennie Valkenier, Abigail G. Thorne, Christopher M. Dias, James A. Cooper, Marion Kieffer, Nathalie Busschaert, Philip A. Gale, David N. Sheppard, Anthony P. Davis	2019	89
9	Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR American Journal of Physiology-Lung Cellular and Molecular Physiology ·Samuel J. Bose, Marcel J. C. Bijvelds, Yi‐Ting Wang, Jia Liu, Zhiwei Cai, Alice G.M. Bot, Hugo R. de Jonge, David N. Sheppard	2019	27
10	Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes Organic & Biomolecular Chemistry ·Christopher M. Dias, Hongyu Li, Hennie Valkenier, Louise E. Karagiannidis, Philip A. Gale, David N. Sheppard, Anthony P. Davis	2018	49
11	Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators JCI Insight ·Sangwoo T. Han, András Rab, Matthew J. Pellicore, Emily F. Davis-Marcisak, Allison F. McCague, Taylor A. Evans, Anya T. Joynt, Zhongzhou Lu, Zhiwei Cai, Karen S. Raraigh, Jeong S. Hong, David N. Sheppard, Eric J. Sorscher, Garry R. Cutting	2018	70
12	Inhibition of Protein Kinase CK2 Closes the CFTR Cl<sup>-</sup> Channel, but has no Effect on the Cystic Fibrosis Mutant ΔF508-CFTR Cellular Physiology and Biochemistry ·Kate J. Treharne, Zhe Xu, Jeng‐Haur Chen, Giles Best, Diane Cassidy, Dieter C. Gruenert, Péter Hegyi, Michael A. Gray, David N. Sheppard, Karl Kunzelmann, Anil Mehta	2009	28
13	Gating of the CFTR Cl⁻ channel by ATP‐driven nucleotide‐binding domain dimerisation The Journal of Physiology ·Tzyh‐Chang Hwang, David N. Sheppard	2009	134
14	Phloxine B Interacts with the Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Sites to Modulate Channel Activity Journal of Biological Chemistry ·Zhiwei Cai, David N. Sheppard	2002	50
15	Mechanism of Glibenclamide Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Cl⁻ Channels Expressed in a Murine Cell Line The Journal of Physiology ·David N. Sheppard, Katherine A. Robinson	1997	184
16	Function of Xenopus Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl- Channels and Use of Human-Xenopus Chimeras to Investigate the Pore Properties of CFTR Journal of Biological Chemistry ·Margaret P. Price, Hiroshi Ishihara, David N. Sheppard, Michael J. Welsh	1996	39
17	Contribution of Proline Residues in the Membrane-spanning Domains of Cystic Fibrosis Transmembrane Conductance Regulator to Chloride Channel Function Journal of Biological Chemistry ·David N. Sheppard, Sue M. Travis, Hiroshi Ishihara, Michael J. Welsh	1996	52
18	Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties Nature ·David N. Sheppard, Devra P. Rich, Lynda S. Ostedgaard, Richard J. Gregory, Alan E. Smith, Michael J. Welsh	1993	374
19	Development of Na+- and K+-Currents in the cocheear ganglion of the chick embryo Neuroscience ·Miguel A. Valverde, David N. Sheppard, Juan Represa, Fernando Giráldez	1992	22
20	Kinetics of voltage- and Ca2+ activation and Ba2+ blockade of a large-conductance K+ channel fromNecturus enterocytes The Journal of Membrane Biology ·David N. Sheppard, Fernando Giráldez, Francisco V. Sepúlveda	1988	45

About David N. Sheppard

David N. Sheppard is a scholar working on Pulmonary and Respiratory Medicine, Molecular Biology, Sensory Systems, Endocrine and Autonomic Systems and Cellular and Molecular Neuroscience, having authored 107 papers that have together received 6.9k indexed citations. Recurring topics across this work include Cystic Fibrosis Research Advances (81 papers), Neonatal Respiratory Health Research (45 papers), Ion channel regulation and function (29 papers), Advanced biosensing and bioanalysis techniques (22 papers), Ion Transport and Channel Regulation (12 papers), Molecular Sensors and Ion Detection (9 papers), Neuroscience and Neural Engineering (7 papers) and Tracheal and airway disorders (7 papers). The work is most often cited by research in Pulmonary and Respiratory Medicine (3.9k citations), Spectroscopy (936 citations), Molecular Biology (3.4k citations), Cellular and Molecular Neuroscience (619 citations) and Endocrine and Autonomic Systems (225 citations). David N. Sheppard has collaborated with scholars based in United Kingdom, United States and Portugal. Frequent co-authors include Michael J. Welsh, Zhiwei Cai, Anthony P. Davis, Hongyu Li, Lynda S. Ostedgaard, Bradley D. Smith, Devra P. Rich, Katherine A. Robinson, Alan E. Smith and Richard J. Gregory. Their work appears in journals such as The Journal of Physiology, Journal of Cystic Fibrosis, Journal of Biological Chemistry, British Journal of Pharmacology and American Journal of Physiology-Lung Cellular and Molecular Physiology.

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