David N. Brems

5.8k citations

81 papers · 4.6k indexed · h-index 41

Impact in

Radiology, Nuclear Medicine and Imaging top 1%
- Monoclonal and Polyclonal Antibodies Research
Molecular Biology top 2%
- Protein purification and stability
- Protein Structure and Dynamics
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research

Papers in

Molecular Biology 71
- Protein Structure and Dynamics 27
- Protein purification and stability 26
- Glycosylation and Glycoproteins Research 13
- Viral Infectious Diseases and Gene Expression in Insects 8
Radiology, Nuclear Medicine and Imaging 20
- Monoclonal and Polyclonal Antibodies Research 20

Co-authors: Michael J. Treuheit Henry A. Havel Margaret Speed Ricci S.M. Plaisted Andrew A. Kosky Gerald W. Becker Yatin R. Gokarn R. Matthew Fesinmeyer
Journals: Biochemistry (22 papers)Journal of Biological Chemistry (11 papers)Protein Science (10 papers)Pharmaceutical Research (7 papers)Journal of Pharmaceutical Sciences (6 papers)
Partner nations: United States Canada

In The Last Decade

David N. Brems

81 papers receiving 4.4k citations

Peers

Countries citing papers authored by David N. Brems

Since Specialization

Citations

This map shows the geographic impact of David N. Brems's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David N. Brems with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David N. Brems more than expected).

Fields of papers citing papers by David N. Brems

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David N. Brems. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David N. Brems. The network helps show where David N. Brems may publish in the future.

Co-authors

The 25 scholars most cited alongside David N. Brems, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David N. Brems Line = papers co-authored together David N. Brems links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Comparison of High-Throughput Biophysical Methods to Identify Stabilizing Excipients for a Model IgG2 Monoclonal Antibody: Conformational Stability and Kinetic Aggregation Measurements Journal of Pharmaceutical Sciences ·Weiqiang Cheng, Sangeeta B. Joshi, Feng He, David N. Brems, Bing He, Bruce A. Kerwin, David B. Volkin, C. Russell Middaugh	2012	57
2	Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions Protein Science ·Yatin R. Gokarn, R. Matthew Fesinmeyer, Atul Saluja, Vladimir I. Razinkov, Susan F. Chase, Thomas M. Laue, David N. Brems	2011	111
3	Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation Biophysical Journal ·Atul Saluja, R. Matthew Fesinmeyer, 유예현, David N. Brems, Yatin R. Gokarn	2010	132
4	Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution Journal of Pharmaceutical Sciences ·Renuka Thirumangalathu, Sampathkumar Krishnan, Margaret Speed Ricci, David N. Brems, Theodore W. Randolph, John F. Carpenter	2009	229
5	Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies Pharmaceutical Research ·R. Matthew Fesinmeyer, 유예현, Atul Saluja, Stephen R. Brych, Liaris Lailli Wonda, Linda O. Narhi, David N. Brems, Yatin R. Gokarn	2008	107
6	Ion‐specific modulation of protein interactions: Anion‐induced, reversible oligomerization of a fusion protein Protein Science ·Yatin R. Gokarn, R. Matthew Fesinmeyer, Atul Saluja, Shawn Cao, 章人坪松, Andrew M. Goetze, Richard L. Remmele, Linda O. Narhi, David N. Brems	2008	40
7	Anion Binding Mediated Precipitation of a Peptibody Pharmaceutical Research ·Atul Saluja, Д. М. Пономарьова, Liaris Lailli Wonda, R. Matthew Fesinmeyer, Richard L. Remmele, Linda O. Narhi, David N. Brems, Yatin R. Gokarn	2008	16
8	Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist Journal of Molecular Biology ·Ramil F. Latypov, Timothy S. Harvey, Dingjiang Liu, Pavel V. Bondarenko, Tadahiko Kohno, Mohannad Al-Qahtani, Robert D. Rosenfeld, Randal R. Ketchem, David N. Brems, Andrei A. Raibekas	2007	14
9	Assignment of backbone 1H, 13C and 15N resonances of human IgG1 Fc (51.4 kDa) Biomolecular NMR Assignments ·Dingjiang Liu, Melanie J. Cocco, Duc Dang Khoi Nguyen, LIONEL PIKE, Da Ren, Luke Li, Richard L. Remmele, David N. Brems	2007	10
10	Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody C_H3 domain Protein Science ·Arnold McAuley, Jaby Jacob, Carl G. Kolvenbach, Dawn Mampreian, SidAli Mohamed Yousfi, Stephen R. Brych, Douglas S. Rehder, Gerd R. Kleemann, David N. Brems, Masazumi Matsumura	2007	85
11	Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study Protein Science ·Rahul S. Rajan, Tiansheng Li, Mohini Aras, Liu Ke-ning, Weston Sutherland, Hiromi Arai, Robert Briddell, Olaf Kinstler, 毅南郷, Yu Zhang, Shipra Bansal, Michael J. Treuheit, David N. Brems	2006	95
12	Charge–charge interactions in the denatured state influence the folding kinetics of ribonuclease Sa Protein Science ·Zofia Bilut-Homplewicz, C. Nick Pace, J. Martin Scholtz, David N. Brems	2005	42
13	Effects of Excipients on the Hydrogen Peroxide-Induced Oxidation of Methionine Residues in Granulocyte Colony-Stimulating Factor Pharmaceutical Research ·Jin Yin, Jhih‐Wei Chu, Margaret Speed Ricci, David N. Brems, Daniel I. C. Wang, Bernhardt L. Trout	2005	30
14	pH Dependence of structural stability of interleukin‐2 and granulocyte colony‐stimulating factor Protein Science ·Margaret Speed Ricci, Casim A. Sarkar, Aymen Alharbi, Douglas A. Lauffenburger, David N. Brems	2003	33
15	Inverse Relationship of Protein Concentration and Aggregation Pharmaceutical Research ·Michael J. Treuheit, Andrew A. Kosky, David N. Brems	2002	154
16	Physicochemical basis for the rapid time‐action of Lys^B28Pro^B29‐insulin: Dissociation of a protein‐ligand complex Protein Science ·Dan-Thuy Van-Pham, J. Radziuk, Henry A. Havel, Mark L. Brader, Shun Li, Steven W. Dodd, John M. Beals, Allen H. Pekar, David N. Brems	1996	67
17	Kinetic Analysis of the Folding of Human Growth Hormone Journal of Biological Chemistry ·J. C. Hascoët, Ewald Amstutz, David N. Brems, Michael R. DeFelippis	1995	41
18	Equilibrium Intermediates in the Denaturation of Human Insulin and Two Monomeric Insulin Analogs Biochemistry ·Rohn Millican, David N. Brems	1994	30
19	Detection of an equilibrium intermediate in the folding of a monomeric insulin analog Biochemistry ·Christopher S. Bryant, Morgan Brock-Smith, Sven Greiner, Katsuhiko TAMAI, Anastasia Zhmayeva, Jale Türkaslan, Ronald E. Chance, David N. Brems	1992	15
20	Improved insulin stability through amino acid substitution Protein Engineering Design and Selection ·David N. Brems, Patricia L. Brown, Christopher S. Bryant, Ronald E. Chance, Mike Heller, Katsuhiko TAMAI, Alita A. Miller, Rohn Millican, James E. Shields, Bruce H. Frank	1992	41

About David N. Brems

David N. Brems is a scholar working on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Endocrinology, Diabetes and Metabolism, Spectroscopy and Cell Biology, having authored 81 papers that have together received 4.6k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (27 papers), Protein purification and stability (26 papers), Monoclonal and Polyclonal Antibodies Research (20 papers), Enzyme Structure and Function (16 papers), Glycosylation and Glycoproteins Research (13 papers), Growth Hormone and Insulin-like Growth Factors (12 papers), Viral Infectious Diseases and Gene Expression in Insects (8 papers) and Hemoglobin structure and function (6 papers). The work is most often cited by research in Radiology, Nuclear Medicine and Imaging (1.2k citations), Molecular Biology (3.6k citations), Spectroscopy (456 citations), Pharmaceutical Science (152 citations) and Biotechnology (169 citations). David N. Brems has collaborated with scholars based in United States and Canada. Frequent co-authors include Michael J. Treuheit, Henry A. Havel, Margaret Speed Ricci, S.M. Plaisted, Andrew A. Kosky, Gerald W. Becker, Yatin R. Gokarn, R. Matthew Fesinmeyer, Atul Saluja and Sampathkumar Krishnan. Their work appears in journals such as Biochemistry, Journal of Biological Chemistry, Protein Science, Pharmaceutical Research and Journal of Pharmaceutical Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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