David J. Chen

26.5k citations

189 papers · 17.9k indexed · 1 hit paper · h-index 76

Cancer Research top 0.2%
- Carcinogens and Genotoxicity Assessment 42
Molecular Biology top 0.1%
- DNA Repair Mechanisms 132
- CRISPR and Genetic Engineering 29
- Genomics and Chromatin Dynamics 19
- DNA and Nucleic Acid Chemistry 17
- Cancer therapeutics and mechanisms 14
Oncology top 0.2%
- Cancer-related Molecular Pathways 42
- PARP inhibition in cancer therapy 18
Aging top 1%
Cell Biology top 0.5%

Co-authors: Sandeep Burma Akihiro Kurimasa Anthony J. Davis Benjamin P.C. Chen Benjamin P. Chen Aroumougame Asaithamby Michael Murphy Eric Weterings
Cited by: Cancer Research Molecular Biology Oncology
Journals: Journal of Biological Chemistry (28 papers)DNA repair (11 papers)Proceedings of the National Academy of Sciences (11 papers)
Partner nations: United States Japan United Kingdom

In The Last Decade

David J. Chen

188 papers receiving 17.7k citations

Hit Papers

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Peers

Countries citing papers authored by David J. Chen

Since Specialization

Citations

This map shows the geographic impact of David J. Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David J. Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David J. Chen more than expected).

Fields of papers citing papers by David J. Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David J. Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David J. Chen. The network helps show where David J. Chen may publish in the future.

Co-authorship network

The 25 scholars most cited alongside David J. Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David J. Chen Line = papers co-authored together David J. Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system Nature Communications ·Sándor Spisák,David J. Chen,博平井,A Touzin,Zhixin Li,Nicola Ferro,Laura Vízkeleti,Viktória Tisza,Pushpamali De Silva,Marios Giannakis,Brian M. Wolpin,Jun Qi,Nilay S. Sethi	2024	5
2	BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle Nucleic Acids Research ·Anthony J. Davis,Allison M. Brennan,Sairei So,Kyung Jong Lee,Eiichiro Mori,Kazi R. Fattah,Jun Yang,David J. Chen	2014	43
3	Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance Molecular Cancer Research ·Prashanthi Javvadi,Haruhiko Makino,Amit Kumar Das,Yu‐Fen Lin,David J. Chen,Benjamin P. Chen,Chaitanya S. Nirodi	2012	36
4	Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs–Dependent DNA Double-Strand Break Repair Molecular Cancer Research ·Mahmoud Toulany,Kyung Jong Lee,Kazi R. Fattah,Yu‐Fen Lin,Sabaké Tianegue Diarra,Martin Schaller,Benjamin P. Chen,David J. Chen,H. Peter Rodemann	2012	142
5	Unrepaired clustered DNA lesions induce chromosome breakage in human cells Proceedings of the National Academy of Sciences ·Aroumougame Asaithamby,Burong Hu,David J. Chen	2011	235
6	Downregulation of Human DAB2IP Gene Expression in Prostate Cancer Cells Results in Resistance to Ionizing Radiation Cancer Research ·Jürgen Buder,Daxing Xie,Thomas Boike,晶弘平山,Sandeep Burma,David J. Chen,Amyn A. Habib,Arup Chakraborty,Jer‐Tsong Hsieh,Debabrata Saha	2010	69
7	Suppression of Nonhomologous End Joining Repair by Overexpression of HMGA2 Cancer Research ·Carmel Peri,Nan Zuo-mi,Shih-Ya Wang,H. Helen Lin,Clay C. C. Wang,Yun Yen,Benjamin P.C. Chen,David J. Chen,David K. Ann	2009	68
8	DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA Cell ·Wen-Ming Chu,Xing Gong,Zhi-Wei Li,Kenji Takabayashi,Honghai Ouyang,Yi Chen,Augusto F. Lois,David J. Chen,Gloria C. Li,Michael Karin,Eyal Raz	2009	2
9	A Human Breast Cell Model of Preinvasive to Invasive Transition Cancer Research ·Aylin Rizki,Valerie M. Weaver,Sunyoung Lee,Gabriela I. Rozenberg,Koei Chin,Connie A. Myers,A. Bednarek,Joni D. Mott,Jeremy R. Semeiks,Leslie R. Grate,Shahzad I. Mian,Alexander D. Borowsky,Roy A. Jensen,Michael O. Idowu,Fanqing Chen,David J. Chen,Ole W. Petersen,Joe W. Gray,Mina J. Bissell	2008	130
10	A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining Journal of Clinical Investigation ·Mirjam van der Burg,Hanna IJspeert,Nicole S. Verkaik,Tuba Turul,Wouter W. Wiegant,Keiko Morotomi‐Yano,Pierre‐Olivier Mari,İlhan Tezcan,David J. Chen,Małgorzata Z. Zdzienicka,Jacques J. M. van Dongen,Dik C. van Gent	2008	200
11	Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality Journal of Molecular Biology ·Jae‐Young Kim,Anne M. Doody,David J. Chen,Tümer Tekin,Michael L. Shuler,David Putnam,Matthew P. DeLisa	2008	141
12	Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) Abrogate EGFR-Mediated Radioprotection in Non–Small Cell Lung Carcinoma Cancer Research ·Amit Kumar Das,Benjamin P. Chen,Michael D. Story,Mitsuo Sato,John D. Minna,David J. Chen,Chaitanya S. Nirodi	2007	129
13	DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells DNA repair ·Bipasha Mukherjee,Chase W. Kessinger,Junya Kobayashi,Benjamin P.C. Chen,David J. Chen,A. Chatterjee,Sandeep Burma	2006	170
14	Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo Cancer Research ·Karel Olbert,Graham Dellaire,Andrew Cuddihy,Farid Jalali,M Molthan,Carla Coackley,Melvyn Folkard,Yang Xu,Benjamin P.C. Chen,David J. Chen,Lothar Lilge,Kevin M. Prise,Mohammad M. Lone,Robert G. Bristow	2005	98
15	Two essential but distinct functions of the mammalian abasic endonuclease Proceedings of the National Academy of Sciences ·Tadahide Izumi,David B. Brown,C. V. Naidu,Kishor K. Bhakat,Mark A. MacInnes,Hiroshi Saito,David J. Chen,Sankar Mitra	2005	194
16	Spontaneous Mutagenesis Is Enhanced in Apex Heterozygous Mice Molecular and Cellular Biology ·Jessica Huamani,C. Alex McMahan,Damon C. Herbert,Robert L. Reddick,John R. McCarrey,D Perdanawati,David J. Chen,Christi A. Walter	2004	62
17	In Vitro and In Vivo Interactions of DNA Ligase IV with a Subunit of the Condensin Complex Molecular Biology of the Cell ·Marcin R. Przewloka,Paige Pardington,Steven M. Yannone,David J. Chen,Robert B. Cary	2003	18
18	DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination Proceedings of the National Academy of Sciences ·Chris Allen,Akihiro Kurimasa,Mark A. Brenneman,David J. Chen,Jac A. Nickoloff	2002	152
19	Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line DNA repair ·Peter Stefanidis,Yuichi Takiguchi,Akira Suda,Takaaki Sugimoto,Hiroshi Miyazawa,Yasuo Takiguchi,Nobuhiro Tanabe,Koichiro Tatsumi,Hiroshi Kimura,Paige Pardington,Fanqing Chen,David J. Chen,Takayuki Kuriyama	2002	60
20	DNA-damage processing in a radiation-sensitive mouse cell line Mutation Research/DNA Repair ·Raymond L. Warters,Bradley W. Lyons,David J. Chen,Koki Sato	1993	15

About David J. Chen

David J. Chen is a scholar working on Cancer Research, Oncology and Molecular Biology, having authored 189 papers that have together received 17.9k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (132 papers), Cancer-related Molecular Pathways (42 papers), Carcinogens and Genotoxicity Assessment (42 papers), CRISPR and Genetic Engineering (29 papers), Genomics and Chromatin Dynamics (19 papers), PARP inhibition in cancer therapy (18 papers), DNA and Nucleic Acid Chemistry (17 papers) and Cancer therapeutics and mechanisms (14 papers). The work is most often cited by research in Cancer Research (3.5k citations), Molecular Biology (15.0k citations) and Oncology (5.7k citations). David J. Chen has collaborated with scholars based in United States, Japan and United Kingdom. Frequent co-authors include Sandeep Burma, Akihiro Kurimasa, Anthony J. Davis, Benjamin P.C. Chen, Benjamin P. Chen, Aroumougame Asaithamby, Michael Murphy, Eric Weterings, Michael D. Story and Scott Peterson. Their work appears in journals such as Journal of Biological Chemistry, DNA repair, Proceedings of the National Academy of Sciences, Radiation Research and Mutation Research/DNA Repair.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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