David J. Chen

26.5k total citations · 1 hit paper
189 papers, 17.9k citations indexed

About

David J. Chen is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, David J. Chen has authored 189 papers receiving a total of 17.9k indexed citations (citations by other indexed papers that have themselves been cited), including 162 papers in Molecular Biology, 71 papers in Oncology and 48 papers in Cancer Research. Recurrent topics in David J. Chen's work include DNA Repair Mechanisms (132 papers), Cancer-related Molecular Pathways (42 papers) and Carcinogens and Genotoxicity Assessment (42 papers). David J. Chen is often cited by papers focused on DNA Repair Mechanisms (132 papers), Cancer-related Molecular Pathways (42 papers) and Carcinogens and Genotoxicity Assessment (42 papers). David J. Chen collaborates with scholars based in United States, Japan and United Kingdom. David J. Chen's co-authors include Sandeep Burma, Akihiro Kurimasa, Anthony J. Davis, Benjamin P.C. Chen, Benjamin P. Chen, Aroumougame Asaithamby, Michael Murphy, Eric Weterings, Michael D. Story and Scott Peterson and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

David J. Chen

188 papers receiving 17.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 1.5k citations Sandeep Burma, Benjamin P. Chen et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
David J. Chen United States	76	15.0k	5.7k	3.5k	1.7k	1.3k	189	17.9k
Penny A. Jeggo United Kingdom	81	18.6k 1.2×	7.0k 1.2×	5.1k 1.5×	1.9k 1.1×	1.7k 1.3×	188	21.8k
Eric J. Stanbridge United States	65	12.4k 0.8×	4.6k 0.8×	4.7k 1.3×	2.3k 1.4×	1.3k 1.0×	275	18.3k
George Iliakis Germany	56	10.0k 0.7×	3.8k 0.7×	3.5k 1.0×	1.7k 1.0×	764 0.6×	253	12.2k
Andrew L. Kung United States	81	16.6k 1.1×	6.6k 1.2×	4.6k 1.3×	1.6k 0.9×	1.4k 1.0×	285	24.2k
Susan P. Lees‐Miller Canada	78	14.2k 0.9×	6.5k 1.1×	2.8k 0.8×	666 0.4×	1.6k 1.2×	181	16.6k
André Nussenzweig United States	75	19.2k 1.3×	6.9k 1.2×	3.6k 1.0×	714 0.4×	1.4k 1.0×	161	22.3k
Emmy P. Rogakou United States	14	9.9k 0.7×	2.9k 0.5×	2.6k 0.8×	901 0.5×	770 0.6×	16	11.6k
Thanos D. Halazonetis United States	54	14.4k 1.0×	7.1k 1.2×	2.8k 0.8×	717 0.4×	2.4k 1.8×	117	17.4k
Roland Kanaar Netherlands	66	13.0k 0.9×	3.3k 0.6×	2.6k 0.8×	705 0.4×	1.1k 0.8×	204	15.4k
Markus Löbrich Germany	52	9.7k 0.6×	3.6k 0.6×	3.3k 1.0×	2.1k 1.2×	721 0.5×	90	11.9k

Countries citing papers authored by David J. Chen

Since Specialization

Citations

This map shows the geographic impact of David J. Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David J. Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David J. Chen more than expected).

Fields of papers citing papers by David J. Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David J. Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David J. Chen. The network helps show where David J. Chen may publish in the future.

Co-authorship network of co-authors of David J. Chen

This figure shows the co-authorship network connecting the top 25 collaborators of David J. Chen. A scholar is included among the top collaborators of David J. Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David J. Chen. David J. Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Spisák, Sándor, David J. Chen, Zhixin Li, et al.. (2024). Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system. Nature Communications. 15(1). 2230–2230. 5 indexed citations

Davis, Anthony J., Sairei So, Kyung Jong Lee, et al.. (2014). BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Nucleic Acids Research. 42(18). 11487–11501. 43 indexed citations

Javvadi, Prashanthi, Haruhiko Makino, Amit Kumar Das, et al.. (2012). Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance. Molecular Cancer Research. 10(10). 1359–1368. 36 indexed citations

Toulany, Mahmoud, Kyung Jong Lee, Kazi R. Fattah, et al.. (2012). Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs–Dependent DNA Double-Strand Break Repair. Molecular Cancer Research. 10(7). 945–957. 142 indexed citations

Asaithamby, Aroumougame, Burong Hu, & David J. Chen. (2011). Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proceedings of the National Academy of Sciences. 108(20). 8293–8298. 235 indexed citations

Xie, Daxing, Thomas Boike, Sandeep Burma, et al.. (2010). Downregulation of Human DAB2IP Gene Expression in Prostate Cancer Cells Results in Resistance to Ionizing Radiation. Cancer Research. 70(7). 2829–2839. 69 indexed citations

Wang, Shih-Ya, H. Helen Lin, Clay C. C. Wang, et al.. (2009). Suppression of Nonhomologous End Joining Repair by Overexpression of HMGA2. Cancer Research. 69(14). 5699–5706. 68 indexed citations

Chu, Wen-Ming, Xing Gong, Zhi-Wei Li, et al.. (2009). DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA. Cell. 136(3). 565–565. 2 indexed citations

Rizki, Aylin, Valerie M. Weaver, Sunyoung Lee, et al.. (2008). A Human Breast Cell Model of Preinvasive to Invasive Transition. Cancer Research. 68(5). 1378–1387. 130 indexed citations

10.

Kim, Jae‐Young, Anne M. Doody, David J. Chen, et al.. (2008). Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality. Journal of Molecular Biology. 380(1). 51–66. 141 indexed citations

11.

Burg, Mirjam van der, Hanna IJspeert, Nicole S. Verkaik, et al.. (2008). A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining. Journal of Clinical Investigation. 119(1). 91–8. 200 indexed citations

12.

Das, Amit Kumar, Benjamin P. Chen, Michael D. Story, et al.. (2007). Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) Abrogate EGFR-Mediated Radioprotection in Non–Small Cell Lung Carcinoma. Cancer Research. 67(11). 5267–5274. 129 indexed citations

13.

Mukherjee, Bipasha, Chase W. Kessinger, Junya Kobayashi, et al.. (2006). DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA repair. 5(5). 575–590. 170 indexed citations

14.

Izumi, Tadahide, David B. Brown, C. V. Naidu, et al.. (2005). Two essential but distinct functions of the mammalian abasic endonuclease. Proceedings of the National Academy of Sciences. 102(16). 5739–5743. 194 indexed citations

15.

Dellaire, Graham, Andrew Cuddihy, Farid Jalali, et al.. (2005). Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo. Cancer Research. 65(23). 10810–10821. 98 indexed citations

16.

Dittmann, Klaus, Claus Mayer, Birgit Fehrenbacher, et al.. (2005). Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase. Journal of Biological Chemistry. 280(35). 31182–31189. 433 indexed citations

17.

Huamani, Jessica, C. Alex McMahan, Damon C. Herbert, et al.. (2004). Spontaneous Mutagenesis Is Enhanced in Apex Heterozygous Mice. Molecular and Cellular Biology. 24(18). 8145–8153. 62 indexed citations

18.

Allen, Chris, Akihiro Kurimasa, Mark A. Brenneman, David J. Chen, & Jac A. Nickoloff. (2002). DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proceedings of the National Academy of Sciences. 99(6). 3758–3763. 152 indexed citations

19.

Takiguchi, Yuichi, Akira Suda, Takaaki Sugimoto, et al.. (2002). Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA repair. 1(4). 299–310. 60 indexed citations

20.

Warters, Raymond L., Bradley W. Lyons, David J. Chen, & Koki Sato. (1993). DNA-damage processing in a radiation-sensitive mouse cell line. Mutation Research/DNA Repair. 293(2). 91–98. 15 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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