Darrell E. O'Brien

727 citations

37 papers · 537 indexed · h-index 13

Impact in

Organic Chemistry top 5%
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Quinazolinone synthesis and applications
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
Nephrology top 10%

Papers in ⓘ

Organic Chemistry 34
- Synthesis and Characterization of Heterocyclic Compounds 22
- Synthesis and Biological Evaluation 14
- Synthesis and biological activity 13
- Synthesis and Reactions of Organic Compounds 13
- Quinazolinone synthesis and applications 7
- Chemical Reaction Mechanisms 4
- Synthesis and Reactivity of Heterocycles 4
Molecular Biology 11
- Phenothiazines and Benzothiazines Synthesis and Activities 4

Co-authors: Roland K. Robins (27 shared papers)Thomas Novinson (11 shared papers)K. SENGA (7 shared papers)Jon P. Miller (5 shared papers)Robert H. Springer (6 shared papers)Lionel N. Simon (3 shared papers)C. C. Cheng (10 shared papers)J. Kobe (3 shared papers)
Journals: Journal of Medicinal Chemistry (15 papers)The Journal of Organic Chemistry (2 papers)Journal of Heterocyclic Chemistry (16 papers)Biochemistry (1 paper)Journal of the American Chemical Society (1 paper)
Partner nations: United States

In The Last Decade

Darrell E. O'Brien

36 papers receiving 469 citations

Peers

Countries citing papers authored by Darrell E. O'Brien

Since Specialization

Citations

This map shows the geographic impact of Darrell E. O'Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Darrell E. O'Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Darrell E. O'Brien more than expected).

Fields of papers citing papers by Darrell E. O'Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Darrell E. O'Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Darrell E. O'Brien. The network helps show where Darrell E. O'Brien may publish in the future.

Co-authors

The 15 scholars most cited alongside Darrell E. O'Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Darrell E. O'Brien Line = papers co-authored together Darrell E. O'Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 37 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Purine analog inhibitors of xanthine oxidase ‐ structure activity relationships and proposed binding of the molybdenum cofactor Journal of Heterocyclic Chemistry ·Roland K. Robins, Ganapathi R. Revankar, Darrell E. O'Brien, Robert H. Springer, Thomas Novinson Anthony Albert, K. SENGA, Jon P. Miller, David Streeter	1985	91
2	3-Substituted 5,7-dimethylpyrazolo[1,5-a]pyrimidines, 3',5'-cyclic AMP phosphodiesterase inhibitors Journal of Medicinal Chemistry ·Thomas Novinson, R. James Hanson, Mary K. Dimmitt, Lionel N. Simon, Roland K. Robins, Darrell E. O'Brien	1974	67
3	Synthesis and antitrichomonal activity of certain pyrazolo[1,5-a]pyrimidines Journal of Medicinal Chemistry ·K. SENGA, Thomas Novinson, Robert H. Springer, Ravindra P. Rao, Darrell E. O'Brien, Roland K. Robins, H.R. WILSON	1975	37
4	Studies on Methylglyoxal Bis(guanylhydrazone)¹ Analogs. II. Structural Variations on Methylglyoxal Bis(guanylhydrazone)² Journal of Medicinal Chemistry ·Fred Baiocchi, C. C. Cheng, William J. Haggerty, Leland R. Lewis, T. K. Liao, Wayne H. Nyberg, Darrell E. O'Brien, Eugene G. Podrebarac	1963	29
5	Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo[1,5-a]pyrimidines Journal of Medicinal Chemistry ·Robert H. Springer, Mary K. Dimmitt, Thomas Novinson, Darrell E. O'Brien, Roland K. Robins, Lionel N. Simon, Jon P. Miller	1976	29
6	Adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors. 2. 3-Substituted 5,7-dialkylpyrazolo[1,5-a]pyrimidines Journal of Medicinal Chemistry ·Thomas Novinson, Jon P. Miller, Mieka B. Scholten, Roland K. Robins, Lionel N. Simon, Darrell E. O'Brien, Rich B. Meyer	1975	28
7	The synthesis and chemical reactions of certain pyrazolo[1,5‐a]‐1,3,5‐triazines Journal of Heterocyclic Chemistry ·J. Kobe, Roland K. Robins, Darrell E. O'Brien	1974	28
8	Synthesis and enzymic activity of various substituted pyrazolo[1,5-a]-1,3,5-triazines as adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitors Journal of Medicinal Chemistry ·K. SENGA, Darrell E. O'Brien, Mieka B. Scholten, Thomas Novinson, Jon P. Miller, Roland K. Robins	1982	27
9	Potential Purine Antagonists. XIX. Synthesis of Some 9-Alkyl(aryl)-2-amino-6-substituted Purines and Related V-Triazolo [d]pyrimidines¹ Journal of the American Chemical Society ·Henry C. Koppel, Darrell E. O'Brien, Roland K. Robins	1959	24
10	Synthesis and enzymic activity of 6-carbethoxy- and 6-ethoxy-3,7-disubstituted pyrazolo[1,5-a]pyrimidines and related derivatives as adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitors Journal of Medicinal Chemistry ·Robert H. Springer, M. B. SCHOLTEN, Darrell E. O'Brien, Thomas Novinson, Jon P. Miller, Roland K. Robins	1982	24
11	Synthesis of unsymmetrical 2,4‐dialkylpyrazolo[1,5‐a]‐1,3,5‐triazines Journal of Heterocyclic Chemistry ·Thomas Novinson, K. SENGA, J. Kobe, Roland K. Robins, Darrell E. O'Brien, Anthony A. Albert	1974	14
12	Pyrimidines. XVIII. 2,4-Diamino-5-nitro-6-arylaminopyrimidines. Nitration Study of 2,4-Diamino-6-chloropyrimidine and a Literature Correction¹ Journal of Medicinal Chemistry ·Darrell E. O'Brien, Chuan Cheng, Wolfgang Pfleiderer	1966	13
13	Pyrimidines. XIII. 2‐ and 6‐substituted 4‐pyrimidinecarboxylic acids Journal of Heterocyclic Chemistry ·G. Doyle Daves, Darrell E. O'Brien, Leland R. Lewis, C. C. Cheng	1964	12
14	Synthesis of 1,3‐dialkylpyrazolo [1,5‐a]‐1,3,5‐triazine‐2,4‐diones isomers of 1,3‐dialkylxanthines Journal of Heterocyclic Chemistry ·K. SENGA, J. Kobe, Roland K. Robins, Darrell E. O'Brien	1975	12
15	A novel rearrangement of 3‐cyanopyrazolo[1,5‐a]pyrimidine to a pyrazolo[3,4‐d]pyrimidine Journal of Heterocyclic Chemistry ·Thomas Novinson, Roland K. Robins, Darrell E. O'Brien	1973	8
16	Synthesis of 3‐hydroxy‐2,1‐benzisothiazole Journal of Heterocyclic Chemistry ·Anthony H. Albert, Roland K. Robins, Darrell E. O'Brien	1973	8
17	Potential Purine Antagonists. XVII. Preparation of Some 6-Alkylthiopurines and 4-Alkylthiopyrazolo[3,4-d]pyrimidines The Journal of Organic Chemistry ·Henry C. Koppel, Darrell E. O'Brien, Roland K. Robins	1959	8
18	Pyrimidines. XXII. 2,4-Diamino-6-arylamino-5-pyrimidinecarboxaldehydes and related compounds Journal of Medicinal Chemistry ·Darrell E. O'Brien, Louis T. Weinstock, C. C. Cheng	1968	8
19	Folic acid analogs. I. p-[[(2,4-Diamino-5-pyrimidinyl)methyl]amino]benzoyl-L-glutamic acid and related compounds Journal of Medicinal Chemistry ·Louis T. Weinstock, Darrell E. O'Brien, Chuan Cheng	1968	7
20	The synthesis of certain 5,7‐Dihydroxyimidazo[1,2‐a\| pyrimidines Journal of Heterocyclic Chemistry ·Ravindra Pralap Rao, Roland K. Robins, Darrell E. O'Brien	1973	7

About Darrell E. O'Brien

Darrell E. O'Brien is a scholar working on Organic Chemistry, Molecular Biology, Nephrology, Infectious Diseases and Pharmacology, having authored 37 papers that have together received 537 indexed citations. Recurring topics across this work include Synthesis and Characterization of Heterocyclic Compounds (22 papers), Synthesis and Biological Evaluation (14 papers), Synthesis and biological activity (13 papers), Synthesis and Reactions of Organic Compounds (13 papers), Quinazolinone synthesis and applications (7 papers), Phenothiazines and Benzothiazines Synthesis and Activities (4 papers), Chemical Reaction Mechanisms (4 papers) and Synthesis and Reactivity of Heterocycles (4 papers). The work is most often cited by research in Organic Chemistry (412 citations), Nephrology (44 citations), Physiology (20 citations), Molecular Biology (148 citations) and Biochemistry (14 citations). Darrell E. O'Brien has collaborated with scholars based in United States. Frequent co-authors include Roland K. Robins, Thomas Novinson, K. SENGA, Jon P. Miller, Robert H. Springer, Lionel N. Simon, C. C. Cheng, J. Kobe, Ganapathi R. Revankar and David Streeter. Their work appears in journals such as Journal of Medicinal Chemistry, The Journal of Organic Chemistry, Journal of Heterocyclic Chemistry, Biochemistry and Journal of the American Chemical Society.

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