Chen‐Leng Cai

8.9k citations

56 papers · 6.4k indexed · 4 hit papers · h-index 32

Impact in

Molecular Biology top 1%
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
Genetics top 2%

Papers in

Urology 5
Molecular Biology 49
- Congenital heart defects research 36
- Renal and related cancers 7
- Developmental Biology and Gene Regulation 6
- Pluripotent Stem Cells Research 5

Co-authors: Sylvia Μ. Evans Ju Chen Xingqun Liang Yunqing Shi Samuel L. Pfaff Xiaoqiang Cai Lei BuLei Yang
Journals: Developmental Biology (8 papers)Development (7 papers)Nature Communications (5 papers)Nature (3 papers)Circulation (3 papers)
Partner nations: United States China France

In The Last Decade

Chen‐Leng Cai

54 papers receiving 6.3k citations

Hit Papers

align trajectories log scale

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies 2011 · 507 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Blood
2008 Nature
2005 Nature
2003 Developmental Cell

Peers

Countries citing papers authored by Chen‐Leng Cai

Since Specialization

Citations

This map shows the geographic impact of Chen‐Leng Cai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Chen‐Leng Cai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Chen‐Leng Cai more than expected).

Fields of papers citing papers by Chen‐Leng Cai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Chen‐Leng Cai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Chen‐Leng Cai. The network helps show where Chen‐Leng Cai may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Chen‐Leng Cai, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Chen‐Leng Cai Line = papers co-authored together Chen‐Leng Cai links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	In vitro generation of a ureteral organoid from pluripotent stem cells Nature Communications ·Pomngarm, Tamandani Mandula, Tomoko Ohmori, Chen‐Leng Cai, Shunsuke Tanigawa, Ryuichi Nishinakamura	2025	0
2	Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway Circulation Research ·裘丽, Guang Song, Gail Williams, Qinshan Li, 真樋口, Chen‐Leng Cai, Sunjay Kaushal, Deqiang Li	2022	28
3	MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4 Circulation Heart Failure ·Tatsuya Aonuma, Bruno Moukette Moukette, Satoshi Kawaguchi, Gede Budi Dewa, Marisa Sepúlveda, Kyle Frick, Yaoliang Tang, Maya Guglin, Subha V. Raman, Chen‐Leng Cai, Suthat Liangpunsakul, Shinichi Nakagawa, Il‐man Kim	2022	23
4	Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm Nature Communications ·Hiroko Nomaru, Yang Liu, Christopher De Bono, Dario Righelli, Xiaodong Xu, Wei Wang, M. Sampo, Silvia E. Racedo, Chang Yiren, Lu Zhang, Chen‐Leng Cai, Claudia Angelini, Lionel Christiaen, Robert G. Kelly, Antonio Baldini, Deyou Zheng, Bernice E. Morrow	2021	32
5	Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury Cell Reports ·Weibin Cai, Jing Tan, Jianyun Yan, Lu Zhang, Xiaoqiang Cai, Haiping Wang, Fang Liu, Maoqing Ye, Chen‐Leng Cai	2019	24
6	Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4 Developmental Biology ·A. A. Abdelghani, Filippo Massa, 马全宝, Valérie Vidal, Ana Sofia Rocha, Elodie P. Gregoire, Chen‐Leng Cai, Kay‐Dietrich Wagner, Andreas Schedl	2018	10
7	Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development Journal of Biological Chemistry ·Jianyun Yan, Jun Li, Jun Hu, Lu Zhang, Chengguo Wei, Nishat Sultana, Xiaoqiang Cai, Weijia Zhang, Chen‐Leng Cai	2018	27
8	REST regulates the cell cycle for cardiac development and regeneration PMC ·Donghong Zhang, Yidong Wang, Pengfei Lu, Ping Wang, М.А. Гуреева, Jianyun Yan, Chen‐Leng Cai, Ching‐Pin Chang, Deyou Zheng, Bingruo Wu, Bin Zhou	2017	2
9	Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node Cell Research ·Meng Wu, Siwu Peng, Jialiang Yang, Zhidong Tu, Xiaoqiang Cai, Chen‐Leng Cai, Zhong Wang, Yong Zhao	2014	25
10	Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development Developmental Biology ·Lu Zhang, Aya Nomura-Kitabayashi, Nishat Sultana, Weibin Cai, Xiaoqiang Cai, Anne Moon, Chen‐Leng Cai	2014	59
11	Smad4 Regulates Ureteral Smooth Muscle Cell Differentiation during Mouse Embryogenesis PLoS ONE ·Jianyun Yan, Lu Zhang, Jin Xu, Nishat Sultana, Jun Hu, Xiaoqiang Cai, Jun Li, Pin‐Xian Xu, Chen‐Leng Cai	2014	14
12	Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney Developmental Biology ·Jin Xu, Xuguang Nie, Xiaoqiang Cai, Chen‐Leng Cai, Pin‐Xian Xu	2014	24
13	Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial–mesenchymal transition via Bmp2 Developmental Biology ·Xiaoqiang Cai, Aya Nomura-Kitabayashi, Weibin Cai, Jianyun Yan, Vincent M. Christoffels, Chen‐Leng Cai	2011	46
14	A myocardial lineage derives from Tbx18 epicardial cells Nature ·Chen‐Leng Cai, Jody Martin, Yunfu Sun, Li Cui, Lianchun Wang, Kunfu Ouyang, Lei Yang, Lei Bu, Xingqun Liang, Xiaoxue Zhang, William B. Stallcup, Christopher P. Denton, Andrew D. McCulloch, Ju Chen, Sylvia Μ. Evans Hit paper breakdown →	2008	599
15	Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling Development ·Jozef Matula, Li-Sheng Wang, Darvisheva Feruza Shuzratovna, Sylvia Μ. Evans, Chen‐Leng Cai, Brian L. Black, Deborah U. Frank, Anne Moon	2006	199
16	Pitx2 regulates cardiac left–right asymmetry by patterning second cardiac lineage-derived myocardium Developmental Biology ·Di Ai, Wei Liu, Lijiang Ma, F.C. Mbakogu, Alin Sabin, Degang Wang, Michael P. Verzi, Chen‐Leng Cai, Philip J. Gage, Sylvia Μ. Evans, Brian L. Black, Nigel A. Brown, James F. Martin	2006	96
17	Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis Developmental Biology ·Lizhu Lin, Lei Bu, Chen‐Leng Cai, Xiaoxue Zhang, Sylvia Μ. Evans	2006	76
18	Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart Developmental Cell ·Chen‐Leng Cai, Xingqun Liang, Yunqing Shi, Qiang Fu, Samuel L. Pfaff, Ju Chen, Sylvia Μ. Evans Hit paper breakdown →	2003	1222
19	Regulation of the tinman Homologues in Xenopus Embryos Developmental Biology ·Duncan B. Sparrow, Chen‐Leng Cai, Surendra Kotecha, Branko Latinkic, Brian T. Cooper, Norma Towers, Sylvia Μ. Evans, Timothy J. Mohun	2000	50
20	BMP Signaling Is Required for Heart Formation in Vertebrates Developmental Biology ·Yunqing Shi, Anat Karmon, Chen‐Leng Cai, Sylvia Μ. Evans	2000	131

About Chen‐Leng Cai

Chen‐Leng Cai is a scholar working on Urology, Molecular Biology, Cardiology and Cardiovascular Medicine, Surgery and Cell Biology, having authored 56 papers that have together received 6.4k indexed citations. Recurring topics across this work include Congenital heart defects research (36 papers), Tissue Engineering and Regenerative Medicine (13 papers), Renal and related cancers (7 papers), Congenital Heart Disease Studies (7 papers), Developmental Biology and Gene Regulation (6 papers), Pluripotent Stem Cells Research (5 papers), Cardiac Fibrosis and Remodeling (5 papers) and Cardiomyopathy and Myosin Studies (4 papers). The work is most often cited by research in Molecular Biology (5.3k citations), Genetics (533 citations), Cardiology and Cardiovascular Medicine (1.1k citations), Surgery (2.1k citations) and Hematology (359 citations). Chen‐Leng Cai has collaborated with scholars based in United States, China and France. Frequent co-authors include Sylvia Μ. Evans, Ju Chen, Xingqun Liang, Yunqing Shi, Samuel L. Pfaff, Xiaoqiang Cai, Lei Bu, Lei Yang, Mingjiang Xu and Xiaoxue Zhang. Their work appears in journals such as Developmental Biology, Development, Nature Communications, Nature and Circulation.

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