Brian Ruffell

15.4k total citations · 9 hit papers
53 papers, 10.7k citations indexed

About

Brian Ruffell is a scholar working on Immunology, Oncology and Molecular Biology. According to data from OpenAlex, Brian Ruffell has authored 53 papers receiving a total of 10.7k indexed citations (citations by other indexed papers that have themselves been cited), including 35 papers in Immunology, 31 papers in Oncology and 13 papers in Molecular Biology. Recurrent topics in Brian Ruffell's work include Cancer Immunotherapy and Biomarkers (20 papers), Immunotherapy and Immune Responses (19 papers) and Immune cells in cancer (17 papers). Brian Ruffell is often cited by papers focused on Cancer Immunotherapy and Biomarkers (20 papers), Immunotherapy and Immune Responses (19 papers) and Immune cells in cancer (17 papers). Brian Ruffell collaborates with scholars based in United States, Canada and Switzerland. Brian Ruffell's co-authors include Lisa M. Coussens, David G. DeNardo, Alycia Gardner, Nesrine I. Affara, Hope S. Rugo, Álvaro de Mingo Pulido, E. Shelley Hwang, Pauline Johnson, Stephen L. Shiao and Dylan Daniel and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Genes & Development.

In The Last Decade

Brian Ruffell

49 papers receiving 10.6k citations

Hit Papers

Macrophages as regulators of tumour imm... 2011 2026 2016 2021 2019 2011 2015 2014 2016 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Macrophages as regulators of tumour immunity and immunotherapy
    2019 1.7k citations David G. DeNardo, Brian Ruffell profile →
  2. Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
    2011 1.3k citations David G. DeNardo, Donal J. Brennan et al. Cancer Discovery profile →
  3. Macrophages and Therapeutic Resistance in Cancer
    2015 1.1k citations Brian Ruffell, Lisa M. Coussens Cancer Cell profile →
  4. Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells
    2014 758 citations Brian Ruffell, Nancy Pryer et al. Cancer Cell profile →
  5. Dendritic Cells and Cancer Immunity
    2016 688 citations Alycia Gardner, Brian Ruffell profile →
  6. Differential macrophage programming in the tumor microenvironment
    2012 687 citations Brian Ruffell, Nesrine I. Affara et al. profile →
  7. Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
    2015 381 citations Andrew J. Gunderson, Megan M. Kaneda et al. Cancer Discovery profile →
  8. Dendritic Cells and Their Role in Immunotherapy
    2020 351 citations Alycia Gardner, Álvaro de Mingo Pulido et al. Frontiers in Immunology profile →
  9. Cell death, therapeutics, and the immune response in cancer
    2023 138 citations Kay Hänggi, Brian Ruffell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Brian Ruffell United States 33 7.1k 5.3k 3.4k 1.5k 1.0k 53 10.7k
David G. DeNardo United States 49 9.0k 1.3× 8.7k 1.6× 4.5k 1.3× 2.3k 1.5× 1.3k 1.3× 110 15.3k
Gregory L. Beatty United States 43 5.4k 0.8× 8.4k 1.6× 3.0k 0.9× 1.8k 1.2× 920 0.9× 102 11.6k
Mikhail Binnewies United States 14 4.5k 0.6× 3.9k 0.7× 2.6k 0.8× 1.0k 0.7× 1.0k 1.0× 20 8.1k
Stefani Spranger United States 40 7.5k 1.1× 7.5k 1.4× 3.7k 1.1× 1.3k 0.9× 1.3k 1.3× 80 12.2k
Seth B. Coffelt United Kingdom 34 4.6k 0.6× 3.6k 0.7× 2.7k 0.8× 1.3k 0.9× 793 0.8× 62 8.3k
Ravindra Majeti United States 55 7.4k 1.0× 3.9k 0.7× 8.0k 2.3× 2.0k 1.3× 510 0.5× 161 16.4k
Thomas F. Gajewski United States 23 6.0k 0.8× 5.4k 1.0× 2.8k 0.8× 1.0k 0.7× 1.1k 1.1× 33 9.4k
Michele W.L. Teng Australia 56 8.3k 1.2× 9.2k 1.7× 3.6k 1.0× 1.4k 1.0× 1.9k 1.9× 95 15.0k
Veena Kapoor United States 44 6.1k 0.9× 5.2k 1.0× 2.5k 0.7× 737 0.5× 777 0.8× 96 10.4k
John S. Yu United States 49 3.1k 0.4× 4.2k 0.8× 3.3k 1.0× 1.1k 0.8× 487 0.5× 171 8.7k

Countries citing papers authored by Brian Ruffell

Since Specialization
Citations

This map shows the geographic impact of Brian Ruffell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian Ruffell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian Ruffell more than expected).

Fields of papers citing papers by Brian Ruffell

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian Ruffell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian Ruffell. The network helps show where Brian Ruffell may publish in the future.

Co-authorship network of co-authors of Brian Ruffell

This figure shows the co-authorship network connecting the top 25 collaborators of Brian Ruffell. A scholar is included among the top collaborators of Brian Ruffell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Brian Ruffell. Brian Ruffell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Senent, Yaiza, Ana Remírez, Diana Llópiz, et al.. (2024). The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune Response. Cancer Immunology Research. 13(3). 384–399. 6 indexed citations
2.
Yu, Xiaoqing, Mengyu Xie, Joseph Johnson, et al.. (2023). Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity. Cancer Immunology Research. 11(4). 466–485. 9 indexed citations
3.
Celias, Daiana P., Kay Hänggi, & Brian Ruffell. (2023). Abstract 678: Investigating the mechanisms involved in HMGB1-dependent DNA uptake and STING activation in dendritic cells. Cancer Research. 83(7_Supplement). 678–678. 1 indexed citations
4.
El-Kenawi, Asmaa, William Dominguez‐Viqueira, Min Liu, et al.. (2021). Macrophage-Derived Cholesterol Contributes to Therapeutic Resistance in Prostate Cancer. Cancer Research. 81(21). 5477–5490. 68 indexed citations
5.
Gardner, Alycia, Álvaro de Mingo Pulido, & Brian Ruffell. (2020). Dendritic Cells and Their Role in Immunotherapy. Frontiers in Immunology. 11. 924–924. 351 indexed citations breakdown →
6.
Trillo-Tinoco, Jimena, Rosa A. Sierra, Eslam Mohamed, et al.. (2019). AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells. Cancer Research. 79(19). 5034–5047. 39 indexed citations
7.
El-Kenawi, Asmaa, Kay Hänggi, & Brian Ruffell. (2019). The Immune Microenvironment and Cancer Metastasis. Cold Spring Harbor Perspectives in Medicine. 10(4). a037424–a037424. 75 indexed citations
8.
Betts, Courtney B., Nathan D. Pennock, Breanna Caruso, et al.. (2018). Mucosal Immunity in the Female Murine Mammary Gland. The Journal of Immunology. 201(2). 734–746. 56 indexed citations
9.
Reddy, Jay P., Rachel L. Atkinson, Richard Larson, et al.. (2018). Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Research and Treatment. 171(2). 283–293. 17 indexed citations
10.
Pulido, Álvaro de Mingo, Alycia Gardner, Hatem Soliman, et al.. (2018). TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer Cell. 33(1). 60–74.e6. 287 indexed citations
11.
Zheng, Hong, Weipeng Zhao, Cihui Yan, et al.. (2016). HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma. Clinical Cancer Research. 22(16). 4119–4132. 264 indexed citations
12.
Pulido, Álvaro de Mingo & Brian Ruffell. (2016). Immune Regulation of the Metastatic Process. Advances in cancer research. 132. 139–163. 11 indexed citations
13.
Gunderson, Andrew J., Megan M. Kaneda, Takahiro Tsujikawa, et al.. (2015). Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discovery. 6(3). 270–285. 381 indexed citations breakdown →
14.
Shiao, Stephen L., Brian Ruffell, David G. DeNardo, et al.. (2015). TH2-Polarized CD4+ T Cells and Macrophages Limit Efficacy of Radiotherapy. Cancer Immunology Research. 3(5). 518–525. 207 indexed citations
15.
Ruffell, Brian & Lisa M. Coussens. (2015). Macrophages and Therapeutic Resistance in Cancer. Cancer Cell. 27(4). 462–472. 1116 indexed citations breakdown →
16.
Strachan, Debbie, Brian Ruffell, Yoko Oei, et al.. (2013). CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells. OncoImmunology. 2(12). e26968–e26968. 314 indexed citations
17.
DeNardo, David G., Donal J. Brennan, Elton Rexhepaj, et al.. (2011). Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy. Cancer Discovery. 1(1). 54–67. 1320 indexed citations breakdown →
18.
Johnson, Pauline & Brian Ruffell. (2009). CD44 and its Role in Inflammation and Inflammatory Diseases. Inflammation & Allergy - Drug Targets. 8(3). 208–220. 172 indexed citations
19.
Ruffell, Brian & Pauline Johnson. (2008). Hyaluronan Induces Cell Death in Activated T Cells through CD44. The Journal of Immunology. 181(10). 7044–7054. 50 indexed citations
20.
Khan, Adil I., Steven M. Kerfoot, Bryan Heit, et al.. (2004). Role of CD44 and Hyaluronan in Neutrophil Recruitment. The Journal of Immunology. 173(12). 7594–7601. 161 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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