Brad E. Hoffman

2.4k citations

35 papers · 2.0k indexed · h-index 25

Impact in

Genetics top 2%
- Virus-based gene therapy research
Oncology top 5%
- CAR-T cell therapy research

Papers in ⓘ

Genetics 21
- Virus-based gene therapy research 21
Oncology 16
- CAR-T cell therapy research 15

Co-authors: Roland W. Herzog (21 shared papers)David M. Markusic (8 shared papers)Cox Terhorst (9 shared papers)Sushrusha Nayak (6 shared papers)Geoffrey D. Keeler (9 shared papers)Ou Cao (5 shared papers)Emilia L. Oleszak (3 shared papers)Michael Barnett (1 shared paper)
Journals: Molecular Therapy (7 papers)Cellular Immunology (3 papers)Molecular Therapy — Methods & Clinical Development (3 papers)Human Gene Therapy (2 papers)Frontiers in Microbiology (2 papers)
Partner nations: United States China Australia

In The Last Decade

Brad E. Hoffman

34 papers receiving 1.9k citations

Peers

Countries citing papers authored by Brad E. Hoffman

Since Specialization

Citations

This map shows the geographic impact of Brad E. Hoffman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brad E. Hoffman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brad E. Hoffman more than expected).

Fields of papers citing papers by Brad E. Hoffman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brad E. Hoffman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brad E. Hoffman. The network helps show where Brad E. Hoffman may publish in the future.

Co-authors

The 25 scholars most cited alongside Brad E. Hoffman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brad E. Hoffman Line = papers co-authored together Brad E. Hoffman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 35 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Immunopathology of secondary‐progressive multiple sclerosis Annals of Neurology ·John W. Prineas, Eunice E. Kwon, Eun‐Sook Cho, Leroy R. Sharer, Michael Barnett, Emilia L. Oleszak, Brad E. Hoffman, B. Paul Morgan	2001	315
2	Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice Proceedings of the National Academy of Sciences ·Dheeraj Verma, Babak Moghimi, Paul A. LoDuca, Harminder D. Singh, Brad E. Hoffman, Roland W. Herzog, Henry Daniell	2010	115
3	High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines Molecular Therapy ·David M. Markusic, Roland W. Herzog, George Aslanidi, Brad E. Hoffman, Baozheng Li, Mengxin Li, Giridhara R. Jayandharan, Chen Ling, Irene Zolotukhin, Wenqin Ma, Sergei Zolotukhin, Arun Srivastava, Zhong Li	2010	111
4	Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies EMBO Molecular Medicine ·David M. Markusic, Brad E. Hoffman, George Q. Perrin, Sushrusha Nayak, Xiaomei Wang, Paul A. LoDuca, Katherine A. High, Roland W. Herzog	2013	101
5	Hepatic Gene Transfer as a Means of Tolerance Induction to Transgene Products Current Gene Therapy ·Paul A. LoDuca, Brad E. Hoffman, Roland W. Herzog	2009	100
6	Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells Blood ·Geoffrey L. Rogers, Jamie L. Shirley, Irene Zolotukhin, Sandeep Kumar, Alexandra Sherman, George Q. Perrin, Brad E. Hoffman, Arun Srivastava, Etiena Basner‐Tschakarjan, Mark A. Wallet, Cox Terhorst, Moanaro Biswas, Roland W. Herzog	2017	96
7	Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid Molecular Therapy ·Koen Vercauteren, Brad E. Hoffman, Irene Zolotukhin, Geoffrey D. Keeler, Jing Xiao, Etiena Basner‐Tschakarjan, Katherine A. High, Hildegund C.J. Ertl, Charles M. Rice, Arun Srivastava, Ype P. de Jong, Roland W. Herzog	2016	93
8	Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B Molecular Therapy ·Ou Cao, Brad E. Hoffman, Babak Moghimi, Sushrusha Nayak, Mario Cooper, Shangzhen Zhou, Hildegund C.J. Ertl, Katherine A. High, Roland W. Herzog	2009	84
9	Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer Human Gene Therapy ·Mario Cooper, Sushrusha Nayak, Brad E. Hoffman, Cox Terhorst, Ou Cao, Roland W. Herzog	2009	78
10	Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis Molecular Therapy ·Geoffrey D. Keeler, Sandeep Kumar, Brett Palaschak, Emily L. Silverberg, David M. Markusic, Noah Jones, Brad E. Hoffman	2017	73
11	The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose Molecular Therapy ·Sandeep Kumar, Brad E. Hoffman, Cox Terhorst, Ype P. de Jong, Roland W. Herzog	2017	61
12	Prophylactic immune tolerance induced by changing the ratio of antigen‐specific effector to regulatory T cells Journal of Thrombosis and Haemostasis ·Sushrusha Nayak, Ou Cao, Brad E. Hoffman, Minton T. Cooper, S Zhou, Mark A. Atkinson, Roland W. Herzog	2009	60
13	Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells Molecular Therapy ·Jamie L. Shirley, Geoffrey D. Keeler, Alexandra Sherman, Irene Zolotukhin, David M. Markusic, Brad E. Hoffman, Laurence Morel, Mark A. Wallet, Cox Terhorst, Roland W. Herzog	2019	59
14	Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia Molecular Therapy — Methods & Clinical Development ·Debalina Sarkar, Moanaro Biswas, Gongxian Liao, Howard R. Seay, George Q. Perrin, David M. Markusic, Brad E. Hoffman, Todd M. Brusko, Cox Terhorst, Roland W. Herzog	2014	58
15	Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer Molecular Therapy ·Brad E. Hoffman, Ashley T. Martino, Brandon K. Sack, Ou Cao, Gongxian Liao, Cox Terhorst, Roland W. Herzog	2011	58
16	Potential for cellular stress response to hepatic factor VIII expression from AAV vector Molecular Therapy — Methods & Clinical Development ·Irene Zolotukhin, David M. Markusic, Brett Palaschak, Brad E. Hoffman, Meera Srikanthan, Roland W. Herzog	2016	57
17	Liver induced transgene tolerance with AAV vectors Cellular Immunology ·Geoffrey D. Keeler, David M. Markusic, Brad E. Hoffman	2017	57
18	Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells Blood ·Xiaomei Wang, Jin Su, Alexandra Sherman, Geoffrey L. Rogers, Gongxian Liao, Brad E. Hoffman, Kam W. Leong, Cox Terhorst, Henry Daniell, Roland W. Herzog	2015	53
19	Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity PLoS ONE ·Ashley T. Martino, Sushrusha Nayak, Brad E. Hoffman, Mario Cooper, Gongxian Liao, David M. Markusic, Barry J. Byrne, Cox Terhorst, Roland W. Herzog	2009	49
20	Low cost delivery of proteins bioencapsulated in plant cells to human non-immune or immune modulatory cells Biomaterials ·Yuhong Xiao, Kwang‐Chul Kwon, Brad E. Hoffman, Aditya Kamesh, Noah Jones, Roland W. Herzog, Henry Daniell	2015	42

About Brad E. Hoffman

Brad E. Hoffman is a scholar working on Genetics, Oncology, Immunology, Biotechnology and Infectious Diseases, having authored 35 papers that have together received 2.0k indexed citations. Recurring topics across this work include Virus-based gene therapy research (21 papers), CAR-T cell therapy research (15 papers), Immunotherapy and Immune Responses (8 papers), CRISPR and Genetic Engineering (8 papers), Viral Infectious Diseases and Gene Expression in Insects (6 papers), Viral gastroenteritis research and epidemiology (6 papers), RNA Interference and Gene Delivery (5 papers) and T-cell and B-cell Immunology (5 papers). The work is most often cited by research in Genetics (972 citations), Oncology (552 citations), Hematology (203 citations), Immunology (368 citations) and Neurology (138 citations). Brad E. Hoffman has collaborated with scholars based in United States, China and Australia. Frequent co-authors include Roland W. Herzog, David M. Markusic, Cox Terhorst, Sushrusha Nayak, Geoffrey D. Keeler, Ou Cao, Emilia L. Oleszak, Michael Barnett, Irene Zolotukhin and B. Paul Morgan. Their work appears in journals such as Molecular Therapy, Cellular Immunology, Molecular Therapy — Methods & Clinical Development, Human Gene Therapy and Frontiers in Microbiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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