Arieh Warshel

59.5k total citations · 40 hit papers
424 papers, 43.0k citations indexed

About

Arieh Warshel is a scholar working on Molecular Biology, Atomic and Molecular Physics, and Optics and Physical and Theoretical Chemistry. According to data from OpenAlex, Arieh Warshel has authored 424 papers receiving a total of 43.0k indexed citations (citations by other indexed papers that have themselves been cited), including 311 papers in Molecular Biology, 146 papers in Atomic and Molecular Physics, and Optics and 64 papers in Physical and Theoretical Chemistry. Recurrent topics in Arieh Warshel's work include Spectroscopy and Quantum Chemical Studies (124 papers), Protein Structure and Dynamics (119 papers) and Photosynthetic Processes and Mechanisms (69 papers). Arieh Warshel is often cited by papers focused on Spectroscopy and Quantum Chemical Studies (124 papers), Protein Structure and Dynamics (119 papers) and Photosynthetic Processes and Mechanisms (69 papers). Arieh Warshel collaborates with scholars based in United States, Israel and China. Arieh Warshel's co-authors include Michael Levitt, Shina Caroline Lynn Kamerlin, Jan Florián, Johan Åqvist, William W. Parson, Zhen T. Chu, Mitsunori Kato, Mats H. M. Olsson, Pankaz K. Sharma and Robert M. Weiss and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

Arieh Warshel

416 papers receiving 41.9k citations

Hit Papers

Theoretical studies of enzymic reactions: Dielectric, ele... 1968 2026 1987 2006 1976 2006 1991 1984 1975 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme
    1976 3.5k citations Arieh Warshel et al. profile →
  2. Electrostatic Basis for Enzyme Catalysis
    2006 1.1k citations Arieh Warshel et al. profile →
  3. Computer Modeling of Chemical Reactions in Enzymes and Solutions
    1991 941 citations Arieh Warshel profile →
  4. Calculations of electrostatic interactions in biological systems and in solutions
    1984 840 citations Arieh Warshel et al. profile →
  5. Computer simulation of protein folding
    1975 779 citations Arieh Warshel et al. profile →
  6. An empirical valence bond approach for comparing reactions in solutions and in enzymes
    1980 738 citations Arieh Warshel et al. Journal of the American Chemical Society profile →
  7. Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches
    1993 688 citations Arieh Warshel et al. profile →
  8. Frozen density functional approach for ab initio calculations of solvated molecules
    1993 634 citations Arieh Warshel et al. profile →
  9. Dynamics of reactions in polar solvents. Semiclassical trajectory studies of electron-transfer and proton-transfer reactions
    1982 546 citations Arieh Warshel profile →
  10. Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites
    1998 493 citations Arieh Warshel profile →
  11. Consistent Force Field for Calculations of Conformations, Vibrational Spectra, and Enthalpies of Cycloalkane and n-Alkane Molecules
    1968 481 citations Arieh Warshel et al. profile →
  12. Modeling electrostatic effects in proteins
    2006 440 citations Arieh Warshel et al. profile →
  13. Bicycle-pedal model for the first step in the vision process
    1976 433 citations Arieh Warshel profile →
  14. A surface constrained all-atom solvent model for effective simulations of polar solutions
    1989 415 citations Arieh Warshel et al. profile →
  15. Energetics of enzyme catalysis.
    1978 412 citations Arieh Warshel Proceedings of the National Academy of Sciences profile →
  16. Computer Simulations of Enzyme Catalysis: Methods, Progress, and Insights
    2003 411 citations Arieh Warshel profile →
  17. How do serine proteases really work?
    1989 397 citations Arieh Warshel, Gábor Náray‐Szabó et al. Biochemistry profile →
  18. Microscopic and semimicroscopic calculations of electrostatic energies in proteins by the POLARIS and ENZYMIX programs
    1993 386 citations Zhen T. Chu, Arieh Warshel et al. profile →
  19. Electrostatic Energy and Macromolecular Function
    1991 379 citations Arieh Warshel et al. profile →
  20. At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
    2009 373 citations Shina Caroline Lynn Kamerlin, Arieh Warshel Proteins Structure Function and Bioinformatics profile →
  21. A local reaction field method for fast evaluation of long-range electrostatic interactions in molecular simulations
    1992 372 citations Arieh Warshel et al. profile →
  22. Investigation of the free energy functions for electron transfer reactions
    1990 344 citations Arieh Warshel et al. profile →
  23. Consistent Calculations of pKa's of Ionizable Residues in Proteins:  Semi-microscopic and Microscopic Approaches
    1997 323 citations Zhen T. Chu, Arieh Warshel et al. The Journal of Physical Chemistry B profile →
  24. Why nature really chose phosphate
    2013 303 citations Shina Caroline Lynn Kamerlin, Arieh Warshel et al. profile →
  25. Protein Control of Redox Potentials of Iron−Sulfur Proteins
    1996 290 citations Arieh Warshel et al. profile →
  26. Calculations of chemical processes in solutions
    1979 289 citations Arieh Warshel profile →
  27. Consistent Force Field Calculations. II. Crystal Structures, Sublimation Energies, Molecular and Lattice Vibrations, Molecular Conformations, and Enthalpies of Alkanes
    1970 287 citations Arieh Warshel et al. profile →
  28. Electrostatic basis of structure-function correlation in proteins
    1981 283 citations Arieh Warshel profile →
  29. On Low-Barrier Hydrogen Bonds and Enzyme Catalysis
    1995 277 citations Arieh Warshel et al. profile →
  30. Polarizable Force Fields:  History, Test Cases, and Prospects
    2007 273 citations Arieh Warshel et al. profile →
  31. Calculations of enzymic reactions: calculations of pKa, proton transfer reactions, and general acid catalysis reactions in enzymes
    1981 267 citations Arieh Warshel Biochemistry profile →
  32. Microscopic models for quantum mechanical calculations of chemical processes in solutions: LD/AMPAC and SCAAS/AMPAC calculations of solvation energies
    1992 264 citations Arieh Warshel et al. profile →
  33. Langevin Dipoles Model for ab Initio Calculations of Chemical Processes in Solution:  Parametrization and Application to Hydration Free Energies of Neutral and Ionic Solutes and Conformational Analysis in Aqueous Solution
    1997 257 citations Arieh Warshel et al. The Journal of Physical Chemistry B profile →
  34. Simulation of free energy relationships and dynamics of SN2 reactions in aqueous solution
    1988 250 citations Arieh Warshel et al. Journal of the American Chemical Society profile →
  35. Microscopic examination of free-energy relationships for electron transfer in polar solvents
    1987 249 citations Arieh Warshel et al. Journal of the American Chemical Society profile →
  36. Progress in Ab Initio QM/MM Free-Energy Simulations of Electrostatic Energies in Proteins: Accelerated QM/MM Studies of pKa, Redox Reactions and Solvation Free Energies
    2008 249 citations Shina Caroline Lynn Kamerlin, Arieh Warshel et al. The Journal of Physical Chemistry B profile →
  37. Electrostatic effects in macromolecules: fundamental concepts and practical modeling
    1998 247 citations Arieh Warshel et al. profile →
  38. Dynamical Contributions to Enzyme Catalysis:  Critical Tests of A Popular Hypothesis
    2006 241 citations Arieh Warshel et al. profile →
  39. Free energy of charges in solvated proteins: microscopic calculations using a reversible charging process
    1986 212 citations Arieh Warshel, Fredy Sussman et al. Biochemistry profile →
  40. Extreme conformational flexibility of the furanose ring in DNA and RNA
    1978 176 citations Arieh Warshel et al. Journal of the American Chemical Society profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Arieh Warshel United States 111 27.3k 14.9k 9.0k 6.8k 5.7k 424 43.0k
Richard A. Friesner United States 96 32.3k 1.2× 10.6k 0.7× 10.2k 1.1× 4.0k 0.6× 12.0k 2.1× 369 61.8k
Jayaraman Chandrasekhar India 44 21.9k 0.8× 11.8k 0.8× 9.2k 1.0× 5.0k 0.7× 9.1k 1.6× 181 47.2k
Jeffry D. Madura United States 37 24.2k 0.9× 9.7k 0.6× 8.3k 0.9× 2.8k 0.4× 4.6k 0.8× 127 43.4k
Lee G. Pedersen United States 43 29.2k 1.1× 7.8k 0.5× 8.7k 1.0× 3.1k 0.4× 5.7k 1.0× 222 50.5k
Alexander D. MacKerell United States 93 38.9k 1.4× 10.7k 0.7× 9.1k 1.0× 3.2k 0.5× 6.0k 1.1× 473 57.6k
Kenneth M. Merz United States 73 23.0k 0.8× 8.0k 0.5× 8.7k 1.0× 4.0k 0.6× 6.7k 1.2× 374 41.5k
Barry Honig United States 108 37.5k 1.4× 6.9k 0.5× 9.0k 1.0× 3.4k 0.5× 3.9k 0.7× 347 51.3k
Piotr Cieplak United States 46 26.4k 1.0× 6.7k 0.4× 7.3k 0.8× 3.0k 0.4× 4.8k 0.8× 126 41.0k
Gregory A. Voth United States 101 14.0k 0.5× 17.8k 1.2× 9.6k 1.1× 4.4k 0.6× 3.2k 0.6× 657 42.1k
Wolfram Saenger Germany 85 23.5k 0.9× 4.9k 0.3× 8.8k 1.0× 4.1k 0.6× 6.4k 1.1× 607 39.6k

Countries citing papers authored by Arieh Warshel

Since Specialization
Citations

This map shows the geographic impact of Arieh Warshel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Arieh Warshel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Arieh Warshel more than expected).

Fields of papers citing papers by Arieh Warshel

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Arieh Warshel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Arieh Warshel. The network helps show where Arieh Warshel may publish in the future.

Co-authorship network of co-authors of Arieh Warshel

This figure shows the co-authorship network connecting the top 25 collaborators of Arieh Warshel. A scholar is included among the top collaborators of Arieh Warshel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Arieh Warshel. Arieh Warshel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhou, Jiao, Xiang Liu, Yan Xu, et al.. (2025). Computational and Experimental Study of the Conformational Variation of the Catalytic Residue His41 of the SARS-CoV-2 Main Protease. The Journal of Physical Chemistry B. 129(21). 5198–5206. 1 indexed citations
2.
3.
Damborský, Jiřı́, et al.. (2025). Biochemical and Computational Characterization of Haloalkane Dehalogenase Variants Designed by Generative AI: Accelerating the SN2 Step. Journal of the American Chemical Society. 147(3). 2747–2755. 5 indexed citations
4.
Warshel, Arieh, et al.. (2025). Understanding hypertrophic cardiomyopathy and its regulation by myosin drugs. Protein Science. 34(10). e70289–e70289.
5.
Chu, Zhen T., et al.. (2024). Exploring the Light-Emitting Agents in Renilla Luciferases by an Effective QM/MM Approach. Journal of the American Chemical Society. 146(20). 13875–13885. 1 indexed citations
6.
Xie, Wen Jun, et al.. (2023). Enhancing luciferase activity and stability through generative modeling of natural enzyme sequences. Proceedings of the National Academy of Sciences. 120(48). e2312848120–e2312848120. 17 indexed citations
7.
8.
Xie, Wen Jun & Arieh Warshel. (2023). Harnessing generative AI to decode enzyme catalysis and evolution for enhanced engineering. National Science Review. 10(12). nwad331–nwad331. 27 indexed citations
9.
Xie, Wen Jun & Arieh Warshel. (2022). Natural Evolution Provides Strong Hints about Laboratory Evolution of Designer Enzymes. Proceedings of the National Academy of Sciences. 119(31). e2207904119–e2207904119. 15 indexed citations
10.
Warshel, Arieh, et al.. (2022). Effect of Environmental Factors on the Catalytic Activity of Intramembrane Serine Protease. Journal of the American Chemical Society. 144(3). 1251–1257. 5 indexed citations
11.
Wang, Juan, Yi‐Ling Chen, Jasper Fuk‐Woo Chan, et al.. (2021). A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. European Journal of Medicinal Chemistry. 215. 113267–113267. 21 indexed citations
12.
Golan, Yarden, Raphael Alhadeff, Arieh Warshel, & Yehuda G. Assaraf. (2019). ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion. PLoS Computational Biology. 15(3). e1006882–e1006882. 30 indexed citations
13.
Astumian, R. Dean, Shayantani Mukherjee, & Arieh Warshel. (2016). The Physics and Physical Chemistry of Molecular Machines. ChemPhysChem. 17(12). 1719–1741. 127 indexed citations
14.
Adamczyk, Andrew J., Jie Cao, Shina Caroline Lynn Kamerlin, & Arieh Warshel. (2011). Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions. Proceedings of the National Academy of Sciences. 108(34). 14115–14120. 173 indexed citations
15.
Messer, Benjamin, et al.. (2009). Multiscale simulations of protein landscapes: Using coarse‐grained models as reference potentials to full explicit models. Proteins Structure Function and Bioinformatics. 78(5). 1212–1227. 61 indexed citations
16.
Vicatos, Spyridon, Maite Roca, & Arieh Warshel. (2009). Effective approach for calculations of absolute stability of proteins using focused dielectric constants. Proteins Structure Function and Bioinformatics. 77(3). 670–684. 61 indexed citations
17.
Roca, Maite, Benjamin Messer, Donald Hilvert, & Arieh Warshel. (2008). On the relationship between folding and chemical landscapes in enzyme catalysis. Proceedings of the National Academy of Sciences. 105(37). 13877–13882. 73 indexed citations
18.
Burykin, Anton, Sonja Braun‐Sand, & Arieh Warshel. (2005). Stochastic QM/MM Models for Proton Transport in Condensed Phase: An Empirical Valence Bond (EVB) Approach. Bulletin of the American Physical Society. 1 indexed citations
19.
Warshel, Arieh, Gábor Náray‐Szabó, Fredy Sussman, & J.-K. Hwang. (1989). How do serine proteases really work?. Biochemistry. 28(9). 3629–3637. 397 indexed citations breakdown →
20.
Warshel, Arieh. (1977). The QCFF/PI+MCA program package efficiency and versatility in molecular mechanics. Computers & Chemistry. 1(3). 195–202. 17 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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