Adam Siepel

27.7k total citations · 4 hit papers
101 papers, 12.5k citations indexed

About

Adam Siepel is a scholar working on Molecular Biology, Genetics and Plant Science. According to data from OpenAlex, Adam Siepel has authored 101 papers receiving a total of 12.5k indexed citations (citations by other indexed papers that have themselves been cited), including 86 papers in Molecular Biology, 34 papers in Genetics and 27 papers in Plant Science. Recurrent topics in Adam Siepel's work include Genomics and Phylogenetic Studies (39 papers), RNA and protein synthesis mechanisms (32 papers) and Chromosomal and Genetic Variations (25 papers). Adam Siepel is often cited by papers focused on Genomics and Phylogenetic Studies (39 papers), RNA and protein synthesis mechanisms (32 papers) and Chromosomal and Genetic Variations (25 papers). Adam Siepel collaborates with scholars based in United States, France and Israel. Adam Siepel's co-authors include Melissa J. Hubisz, Kate R. Rosenbloom, Katherine S. Pollard, David Haussler, Gill Bejerano, Charles G. Danko, Jakob Skou Pedersen, Ilan Gronau, Brad Gulko and Webb Miller and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Adam Siepel

99 papers receiving 12.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

2005 2.8k citations Adam Siepel, Kate R. Rosenbloom et al. Genome Research profile →
Detection of nonneutral substitution rates on mammalian phylogenies

2009 1.4k citations Katherine S. Pollard, Melissa J. Hubisz et al. Genome Research profile →
An RNA gene expressed during cortical development evolved rapidly in humans

2006 672 citations Katherine S. Pollard, Adam Siepel et al. profile →
Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

2014 442 citations Leighton J. Core, André L. Martins et al. Nature Genetics profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Adam Siepel United States	44	9.3k	4.2k	2.0k	1.8k	477	101	12.5k
Anthony Philippakis United States	30	6.6k 0.7×	4.0k 0.9×	1.5k 0.7×	1.3k 0.7×	527 1.1×	70	11.6k
Kerstin Lindblad‐Toh United States	53	7.0k 0.8×	5.0k 1.2×	1.6k 0.8×	1.1k 0.6×	828 1.7×	159	13.0k
Yoav Gilad United States	67	11.7k 1.3×	5.1k 1.2×	1.9k 0.9×	1.4k 0.8×	1.1k 2.4×	136	16.9k
Christopher Hartl United States	11	6.6k 0.7×	5.5k 1.3×	2.0k 1.0×	1.6k 0.9×	606 1.3×	14	12.7k
Gill Bejerano United States	38	10.3k 1.1×	3.8k 0.9×	2.0k 1.0×	1.8k 1.0×	693 1.5×	93	13.0k
Jared Maguire United States	8	4.5k 0.5×	3.7k 0.9×	1.5k 0.7×	1.1k 0.6×	380 0.8×	8	8.5k
Guillermo del Angel United States	8	5.8k 0.6×	4.9k 1.2×	1.9k 0.9×	1.6k 0.9×	616 1.3×	15	11.7k
Manuel A. Rivas United States	5	4.3k 0.5×	3.6k 0.8×	1.4k 0.7×	1.0k 0.6×	444 0.9×	5	8.4k
Ryan Poplin United States	8	6.7k 0.7×	5.3k 1.2×	2.0k 1.0×	1.8k 1.0×	617 1.3×	12	14.1k
Ross C. Hardison United States	65	14.1k 1.5×	3.7k 0.9×	1.4k 0.7×	2.9k 1.6×	1.1k 2.2×	236	18.5k

Countries citing papers authored by Adam Siepel

Since Specialization

Citations

This map shows the geographic impact of Adam Siepel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Adam Siepel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Adam Siepel more than expected).

Fields of papers citing papers by Adam Siepel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Adam Siepel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Adam Siepel. The network helps show where Adam Siepel may publish in the future.

Co-authorship network of co-authors of Adam Siepel

This figure shows the co-authorship network connecting the top 25 collaborators of Adam Siepel. A scholar is included among the top collaborators of Adam Siepel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Adam Siepel. Adam Siepel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Ju, Xiang-Chun, Shin‐Yu Lee, Laís Ceschini Machado, et al.. (2025). The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior. Proceedings of the National Academy of Sciences. 122(32). e2508540122–e2508540122. 1 indexed citations

Struck, Travis J., Andrew H. Vaughn, Dylan D. Ray, et al.. (2025). GHIST 2024: The First Genomic History Inference Strategies Tournament. Molecular Biology and Evolution. 42(11).

Zhao, Yixin, et al.. (2025). Probabilistic and machine-learning methods for predicting local rates of transcription elongation from nascent RNA sequencing data. Nucleic Acids Research. 53(4).

Tajima, Yoko, Keiichi Ito, Wei Wang, et al.. (2025). A humanized NOVA1 splicing factor alters mouse vocal communications. Nature Communications. 16(1). 1542–1542. 3 indexed citations

Scheben, Armin, R. P. Hassett, Daniele Ramazzotti, et al.. (2024). Clonal Lineage Tracing with Somatic Delivery of Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer. Cancer Discovery. 14(10). 1990–2009. 4 indexed citations

Zhao, Yixin, et al.. (2023). Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells. Nucleic Acids Research. 51(21). e106–e106. 5 indexed citations

Wu, Yaoyao, Baoxing Song, M. Cinta Romay, et al.. (2022). A multiple alignment workflow shows the effect of repeat masking and parameter tuning on alignment in plants. The Plant Genome. 15(2). e20204–e20204. 8 indexed citations

Zhao, Yixin, et al.. (2021). Deconvolution of expression for nascent RNA-sequencing data (DENR) highlights pre-RNA isoform diversity in human cells. Bioinformatics. 37(24). 4727–4736. 3 indexed citations

Dukler, Noah, Yi-Fei Huang, & Adam Siepel. (2020). Phylogenetic Modeling of Regulatory Element Turnover Based on Epigenomic Data. Molecular Biology and Evolution. 37(7). 2137–2152. 6 indexed citations

10.

Salman‐Minkov, Ayelet, Leonardo Campagna, Melissa J. Hubisz, et al.. (2020). Genomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweeps. Proceedings of the National Academy of Sciences. 117(48). 30554–30565. 46 indexed citations

11.

Joly‐Lopez, Zoé, Adrian E. Platts, Brad Gulko, et al.. (2020). An inferred fitness consequence map of the rice genome. Nature Plants. 6(2). 119–130. 24 indexed citations

12.

Gulko, Brad & Adam Siepel. (2018). An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences. Nature Genetics. 51(2). 335–342. 21 indexed citations

13.

Huang, Yi-Fei, Brad Gulko, & Adam Siepel. (2017). Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data. Nature Genetics. 49(4). 618–624. 214 indexed citations

14.

Gulko, Brad, Melissa J. Hubisz, Ilan Gronau, & Adam Siepel. (2015). A method for calculating probabilities of fitness consequences for point mutations across the human genome. Nature Genetics. 47(3). 276–283. 187 indexed citations

15.

Danko, Charles G., Leighton J. Core, André L. Martins, et al.. (2015). Identification of active transcriptional regulatory elements from GRO-seq data. Nature Methods. 12(5). 433–438. 137 indexed citations

16.

Mohammed, Jaaved, Adam Siepel, & Eric C. Lai. (2014). Diverse modes of evolutionary emergence and flux of conserved microRNA clusters. RNA. 20(12). 1850–1863. 35 indexed citations

17.

Rasmussen, Matthew D., Melissa J. Hubisz, Ilan Gronau, & Adam Siepel. (2014). Genome-Wide Inference of Ancestral Recombination Graphs. PLoS Genetics. 10(5). e1004342–e1004342. 212 indexed citations

18.

Wen, Jiayu, Jaaved Mohammed, Diane Bortolamiol-Bécet, et al.. (2014). Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Research. 24(7). 1236–1250. 55 indexed citations

19.

Pollard, Katherine S., Melissa J. Hubisz, Kate R. Rosenbloom, & Adam Siepel. (2009). Detection of nonneutral substitution rates on mammalian phylogenies. Genome Research. 20(1). 110–121. 1418 indexed citations breakdown →

20.

Bakker, Elisabeth S., René van der Wal, Peter Esselink, & Adam Siepel. (1999). Exploitation of a new staging area in the Dutch Wadden Sea by Greylag Geese Anser anser: the importance of food-plant dynamics. Ardea. 87(1). 1–13. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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