Adam L. Orr

4.5k total citations · 2 hit papers
38 papers, 3.6k citations indexed

About

Adam L. Orr is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Adam L. Orr has authored 38 papers receiving a total of 3.6k indexed citations (citations by other indexed papers that have themselves been cited), including 29 papers in Molecular Biology, 11 papers in Cellular and Molecular Neuroscience and 10 papers in Neurology. Recurrent topics in Adam L. Orr's work include Mitochondrial Function and Pathology (23 papers), ATP Synthase and ATPases Research (9 papers) and Genetic Neurodegenerative Diseases (8 papers). Adam L. Orr is often cited by papers focused on Mitochondrial Function and Pathology (23 papers), ATP Synthase and ATPases Research (9 papers) and Genetic Neurodegenerative Diseases (8 papers). Adam L. Orr collaborates with scholars based in United States, Canada and Netherlands. Adam L. Orr's co-authors include Martin D. Brand, Irina V. Perevoshchikova, Casey L. Quinlan, Xiao‐Jiang Li, Jason R. Treberg, Martin Hey‐Mogensen, Brian A.C. Ackrell, Shihua Li, Anna G. Orr and Stephen F. Traynelis and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and The Journal of Experimental Medicine.

In The Last Decade

Adam L. Orr

38 papers receiving 3.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

2012 541 citations Casey L. Quinlan, Adam L. Orr et al. Journal of Biological Chemistry profile →
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

2013 477 citations Casey L. Quinlan, Irina V. Perevoshchikova et al. profile →

Peers

Adam L. Orr

CMN

PHYSI

NEURO

Brian M. Polster United States

László Tretter Hungary

Amalia M. Dolga Netherlands

Sandra Moreno Italy

Israel Sekler Israel

Marc Gleichmann United States

Elizabeth A. Jonas United States

Francesc X. Soriano Spain

Gino Cortopassi United States

Antonella Scorziello Italy

Brian M. Polster United States

Adam L. Orr

2.6k ×1.0

540 ×0.7

CMN

787 ×1.1

PHYSI

309 ×0.9

NEURO

314 ×0.9

NEURO

Citations per year, relative to Adam L. Orr Adam L. Orr (= 1×) peers Brian M. Polster

Countries citing papers authored by Adam L. Orr

Since Specialization

Citations

This map shows the geographic impact of Adam L. Orr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Adam L. Orr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Adam L. Orr more than expected).

Fields of papers citing papers by Adam L. Orr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Adam L. Orr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Adam L. Orr. The network helps show where Adam L. Orr may publish in the future.

Co-authorship network of co-authors of Adam L. Orr

This figure shows the co-authorship network connecting the top 25 collaborators of Adam L. Orr. A scholar is included among the top collaborators of Adam L. Orr based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Adam L. Orr. Adam L. Orr is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Barnett, Daniel, Till S. Zimmer, Samantha M. Meadows, et al.. (2025). Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology. Nature Metabolism. 7(11). 2300–2323. 1 indexed citations

Zimmer, Till S., Daniel Barnett, Noopur V. Khobrekar, et al.. (2025). Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology. Neurobiology of Disease. 211. 106939–106939. 1 indexed citations

Bennett, Neal K., et al.. (2024). Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. Proceedings of the National Academy of Sciences. 121(3). e2307904121–e2307904121. 9 indexed citations

Zimmer, Till S., et al.. (2024). Astrocytes in selective vulnerability to neurodegenerative disease. Trends in Neurosciences. 47(4). 289–302. 22 indexed citations

Meadows, Samantha M., Soomin C. Song, Yaron Bram, et al.. (2023). Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines. Science Advances. 9(16). eade1282–eade1282. 25 indexed citations

Cakir, Zeynep, Samuel J. Lord, Yuan Zhou, et al.. (2023). Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Molecular & Cellular Proteomics. 22(5). 100541–100541. 2 indexed citations

Orr, Adam L., Chaeyoung Kim, David Jimenez‐Morales, et al.. (2019). Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. Journal of Alzheimer s Disease. 68(3). 991–1011. 58 indexed citations

Pathak, Divya, Amandine Berthet, Jacob Bendor, et al.. (2017). Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. 4(2). ENEURO.0216–16.2017. 14 indexed citations

Orr, Adam L., Florentine U. Rutaganira, Eric J. Huang, et al.. (2017). Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochemistry International. 109. 106–116. 33 indexed citations

10.

Hey‐Mogensen, Martin, Renata L.S. Goncalves, Adam L. Orr, & Martin D. Brand. (2014). Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria. Free Radical Biology and Medicine. 72. 149–155. 69 indexed citations

11.

Orr, Adam L., Deepthi Ashok, Melissa R. Sarantos, et al.. (2014). Novel Inhibitors of Mitochondrial sn-Glycerol 3-phosphate Dehydrogenase. PLoS ONE. 9(2). e89938–e89938. 49 indexed citations

12.

Orr, Adam L., Deborah S. Cooper, Marla Gearing, et al.. (2013). NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease. Neuroscience Letters. 547. 16–20. 22 indexed citations

13.

Brand, Martin D., Adam L. Orr, Irina V. Perevoshchikova, & Casey L. Quinlan. (2013). The role of mitochondrial function and cellular bioenergetics in ageing and disease. British Journal of Dermatology. 169. 1–8. 210 indexed citations

14.

Orr, Adam L., Deepthi Ashok, Melissa R. Sarantos, et al.. (2013). Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radical Biology and Medicine. 65. 1047–1059. 69 indexed citations

15.

Perevoshchikova, Irina V., Casey L. Quinlan, Adam L. Orr, Akos A. Gerencser, & Martin D. Brand. (2013). Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. Free Radical Biology and Medicine. 61. 298–309. 101 indexed citations

16.

Orr, Anna G., Adam L. Orr, Xiao‐Jiang Li, Robert E. Gross, & Stephen F. Traynelis. (2009). Adenosine A2A receptor mediates microglial process retraction. Nature Neuroscience. 12(7). 872–878. 284 indexed citations

17.

Li, Xiao‐Jiang, Adam L. Orr, & Shihua Li. (2009). Impaired mitochondrial trafficking in Huntington's disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802(1). 62–65. 51 indexed citations

18.

Wang, Chuan-En, Adam L. Orr, Shang‐Hsun Yang, et al.. (2008). Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. 17(17). 2738–2751. 136 indexed citations

19.

Orr, Adam L., Shanshan Huang, Meredith Roberts, et al.. (2008). Sex-dependent Effect of BAG1 in Ameliorating Motor Deficits of Huntington Disease Transgenic Mice. Journal of Biological Chemistry. 283(23). 16027–16036. 27 indexed citations

20.

Orr, Adam L., Shihua Li, Chuan-En Wang, et al.. (2008). N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking. Journal of Neuroscience. 28(11). 2783–2792. 331 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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