Standout Papers

The Onpattro story and th... 2012 2026 2016 2021 2019 2012 2015 2012 2017 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation benchmark for papers published in the same subfield and year, or reaches the top citation threshold in at least one of its specific research topics.

  1. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
    2019 1.1k citations Akin Akinc, Martin A. Maier et al. Nature Nanotechnology profile →
  2. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
    2012 965 citations Muthusamy Jayaraman, Steven M. Ansell et al. Angewandte Chemie International Edition profile →
  3. Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
    2015 678 citations Norbert Pardi, Steven Tuyishime et al. Journal of Controlled Release profile →
  4. Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
    2012 543 citations Nathan M. Belliveau, Jens Huft et al. Molecular Therapy — Nucleic Acids profile →
  5. Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
    2017 265 citations Norbert Pardi, Anthony Secreto et al. Nature Communications profile →
  6. A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
    2022 211 citations Claudia P. Arevalo, Marcus J. Bolton et al. Science profile →
  7. A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice
    2020 204 citations Alec W. Freyn, Jamile Ramos da Silva et al. Molecular Therapy profile →
  8. Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
    2018 200 citations Norbert Pardi, Kaela Parkhouse et al. Nature Communications profile →
  9. Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
    2021 177 citations István Tombácz, Dorottya Laczkó et al. Molecular Therapy profile →
  10. In vivo hematopoietic stem cell modification by mRNA delivery
    2023 165 citations Laura Breda, Tyler E. Papp et al. Science profile →
  11. PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
    2018 151 citations Hamideh Parhiz, Vladimir V. Shuvaev et al. Journal of Controlled Release profile →
  12. Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
    2021 101 citations Fatima Rizvi, Anna R. Smith et al. Nature Communications profile →
  13. Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
    2023 84 citations Jamile Ramos da Silva, Hiromi Muramatsu et al. Science Translational Medicine profile →
  14. Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
    2023 64 citations Jennifer Connors, Gina Cusimano et al. Communications Biology profile →
  15. Development of an mRNA-lipid nanoparticle vaccine against Lyme disease
    2023 43 citations Gunjan Arora, Thomas Hart et al. Molecular Therapy profile →

Immediate Impact

69 by Nobel laureates 13 from Science/Nature 438 hit
Sub-graph 1 of 12

Citing Papers

Endosomal escape: A bottleneck for LNP-mediated therapeutics
2024 Hit
Chemically Modified Platforms for Better RNA Therapeutics
2024 Hit
294 intermediate papers

Works of Ying K. Tam being referenced

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
2019 Hit
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 HitNobel
and 39 more

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Ying K. Tam 6.4k 2.5k 1.8k 1.2k 871 107 9.1k
Rongguang Zhang 5.6k 0.9× 2.3k 0.9× 1.4k 0.8× 1.1k 0.9× 783 0.9× 162 10.5k
Yizhou Dong 6.3k 1.0× 1.5k 0.6× 913 0.5× 1.0k 0.9× 724 0.8× 108 9.1k
Norbert Pardi 4.9k 0.8× 2.5k 1.0× 3.0k 1.7× 1.1k 0.9× 742 0.9× 81 8.3k
Thomas D. Madden 5.5k 0.9× 1.0k 0.4× 1.1k 0.6× 678 0.6× 493 0.6× 63 7.4k
Barbara L. Mui 5.1k 0.8× 1.3k 0.5× 1.2k 0.6× 1.0k 0.9× 394 0.5× 36 6.4k
Steven Fiering 5.4k 0.8× 2.4k 1.0× 585 0.3× 1.7k 1.5× 1.4k 1.6× 157 10.1k
Tal Zaks 4.1k 0.6× 1.9k 0.7× 1.2k 0.7× 744 0.6× 1.8k 2.1× 51 6.7k
Katalin Karikó 9.0k 1.4× 4.1k 1.6× 2.3k 1.3× 2.2k 1.9× 1.2k 1.4× 91 13.0k
Kathryn A. Whitehead 7.4k 1.2× 1.2k 0.5× 765 0.4× 1.1k 1.0× 454 0.5× 74 10.1k
Thilo Stehle 5.4k 0.8× 1.9k 0.7× 2.1k 1.2× 2.2k 1.9× 1.9k 2.2× 190 11.8k

All Works

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Rankless by CCL
2026