Citation Impact
Citing Papers
Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C
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Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
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Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Voltage sensor conformations in the open and closed states in rosetta structural models of K + channels
2006 StandoutNobel
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Emergence of symmetry in homooligomeric biological assemblies
2008 StandoutNobel
The Tissue Factor Requirement in Blood Coagulation
2005
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction
2020
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase
2003
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
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Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
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A critical role for extracellular protein disulfide isomerase during thrombus formation in mice
2008
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
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Mechanisms of Thrombus Formation
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
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The cytokine‐mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia
1997
Contribution of platelets to tumour metastasis
2011 Standout
The impact of the inflammatory response on coagulation
2004
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
2007
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor
2013
Host–pathogen interactions in sepsis
2007
Tissue Factor-Dependent Coagulation Is Preferentially Up-Regulated within Arterial Branching Areas in a Baboon Model of Escherichia coli Sepsis
2005
The Human Intestinal Microbiome in Health and Disease
2016 Standout
Microparticle‐associated tissue factor activity: a link between cancer and thrombosis?
2007
Beyond natural antibodies: the power of in vitro display technologies
2011
Development and Disease in Proteinase-Deficient Mice
1998
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Angiogenesis in cancer and other diseases
2000 StandoutNature
Neutrophils express tissue factor in a monkey model of sepsis
2000
Tumor-Associated Macrophages: From Mechanisms to Therapy
2014 Standout
Disseminated intravascular coagulation: Clinical and laboratory aspects
1998
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
2005
Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty
2000
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
2003
Regulation of Extrinsic Pathway Factor Xa Formation by Tissue Factor Pathway Inhibitor
1998
Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation
2008
Targeted Identification of Metastasis-associated Cell-surface Sialoglycoproteins in Prostate Cancer
2011
The hypoxic tumor microenvironment: A driving force for breast cancer progression
2015 StandoutNobel
Role of tissue factor in embryonic blood vessel development
1996 Nature
Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.
1993
Adding New Chemistries to the Genetic Code
2010
Continuous directed evolution of aminoacyl-tRNA synthetases
2017
Anatomy of hot spots in protein interfaces
1998 Standout
Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane
1998 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Cell biology of tissue factor, the principal initiator of blood coagulation
1996
The Protein C Pathway
2003
Coagulation disorders in septic shock
1993
A timeline of tumour-associated macrophage biology
2023
Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?
1997
Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
1994
Targeting proteinase-activated receptors: therapeutic potential and challenges
2012
Atherosclerosis — An Inflammatory Disease
1999 Standout
A Mass Spectrometric-Derived Cell Surface Protein Atlas
2015
The C1q domain containing proteins: Where do they come from and what do they do?
2010
Disseminated Intravascular Coagulation
1999 Standout
Harmful molecular mechanisms in sepsis
2008
Points of control in inflammation
2002 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.
1993
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Protein–Protein Docking with Simultaneous Optimization of Rigid-body Displacement and Side-chain Conformations
2003 StandoutNobel
In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease
1996
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Optimizing non-natural protein function with directed evolution
2010 StandoutNobel
Extracellular histones are major mediators of death in sepsis
2009 Standout
The immunopathogenesis of sepsis
2002 StandoutNature
Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR
1996 StandoutNobel
Allosteric disulfide bonds in thrombosis and thrombolysis
2006
Tissue Factor Pathway Inhibitor and von Willebrand Factor Antigen Levels in Adult Respiratory Distress Syndrome and in a Primate Model of Sepsis
1995
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Endogenous Inhibitors of Angiogenesis
2005
The role of platelets in decrypting monocyte tissue factor
2001
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Vascular damage from smoking: disease mechanisms at the arterial wall
1998
Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients
1996
Tissue factor activity in whole blood
2004
Toward High-Resolution de Novo Structure Prediction for Small Proteins
2005 StandoutScienceNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Herpesviruses in Atherosclerosis and Thrombosis
1998
Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa
2004
Broken Barriers: A New Take on Sepsis Pathogenesis
2011
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage
1991
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Interleukin-10 Inhibits Activation of Coagulation and Fibrinolysis During Human Endotoxemia
1997
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells
2004
Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow
2005
Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro
1998
Stop That Cell! β-Arrestin-Dependent Chemotaxis: A Tale of Localized Actin Assembly and Receptor Desensitization
2006
Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature
1997 Science
Tissue Factor and Factor VIIa Receptor/Ligand Interactions Induce Proinflammatory Effects in Macrophages
1999
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Allosteric Disulfide Bonds
2006
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation
1993
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Heparin Blunts Endotoxin-Induced Coagulation Activation
1999
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
2000
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice
2013
Human platelets synthesize and express functional tissue factor
2007
Disseminated Intravascular Coagulation
1999
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Activity-Based Profiling of Proteases
2014
Tissue Factor Pathway Inhibitor Reduces Experimental Lung Metastasis of B16 Melanoma
2002
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity
2004
Expression of tissue factor procoagulant activity: regulation by cytosolic calcium.
1990
Works of Wolfram Ruf being referenced
Mutational Mapping of Functional Residues in Tissue Factor: Identification of Factor VII Recognition Determinants in Both Structural Modules of the Predicted Cytokine Receptor Homology Domain
1994
Thrombin Generation and the Pathogenesis of Cancer
2006
Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
2003
Tissue factor in cancer angiogenesis and metastasis
1996
Splice variants of tissue factor promote monocyte‐endothelial interactions by triggering the expression of cell adhesion molecules via integrin‐mediated signaling
2011
Energetic Contributions and Topographical Organization of Ligand Binding Residues of Tissue Factor
1995
Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling
2005
Plasmin-induced Migration of Endothelial Cells
2002
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
2008 Nature
Emerging Insights in Tissue Factor-Dependent Signaling Events
2006
Tissue factor in cancer progression and angiogenesis
2010
Exosite Interactions Determine the Affinity of Factor X for the Extrinsic Xase Complex
2000
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
2012 Nature
Tissue Factor Coagulant Function Is Enhanced by Protein-disulfide Isomerase Independent of Oxidoreductase Activity
2007
Effector Cell Protease Receptor-1 Is a Vascular Receptor for Coagulation Factor Xa
1996
Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis.
1998
Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation
2004
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF·5G9 complex 1 1Edited by D. C. Rees
1998
Active Site Modification of Factor VIIa Affects Interactions of the Protease Domain with Tissue Factor
1997
Cell Surface Proteomics Identifies Molecules Functionally Linked to Tumor Cell Intravasation
2008
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
2004
Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes
2005
Tissue factor and PAR signaling in tumor progression
2007
Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line.
1989
Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function
1991
Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice
2008
Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.
1992
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells
2011
Structural biology of tissue factor, the initiator of thrombogenesis in vivo 1
1994
Cross-talk of Integrin α3β1 and Tissue Factor in Cell Migration
2004
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
2012
Importance of Factor VIIa Gla-Domain Residue Arg-36 for Recognition of the Macromolecular Substrate Factor X Gla-Domain
1999
An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma.
1991
Tissue Factor: molecular recognition and cofactor function
1995
A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280
1998
Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids
2009
Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
2003
Key ligand interface residues in tissue factor contribute independently to factor VIIa binding.
1994
Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.
1995
Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.
1991
Evidence for Activation of Tissue Factor by an Allosteric Disulfide Bond
2006
Dimerization of Tissue Factor Supports Solution-Phase Autoactivation of Factor VII without Influencing Proteolytic Activation of Factor X
2000
Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function
1991
Antibody mapping of tissue factor implicates two different exon-encoded regions in function
1991
Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock.
1992
Disulfide isomerization switches tissue factor from coagulation to cell signaling
2006
The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site
1992
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
2002 Science
Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.
1991
Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions
1991
Recombinant soluble human tissue factor secreted by Saccharomyces cerevisiae and refolded from Escherichia coli inclusion bodies: glycosylation of mutants, activity and physical characterization
1995
Protease-Activated Receptors (PAR1 and PAR2) Contribute to Tumor Cell Motility and Metastasis
2004
Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
2001
Immunochemical termination of self-tolerance
2008
The Structural Biology of Expression and Function of Tissue Factor
1991
The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII
1991
Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa
1996
Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway.
1996
Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
2007