Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
An Engineered Microbial Platform for Direct Biofuel Production from Brown Macroalgae
2012 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
2019 StandoutNobel
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Targeting histone lysine demethylases — Progress, challenges, and the future
2014
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
Recent advances in the catalytic asymmetric synthesis of β-amino acids
2010 StandoutNobel
Automated protein model building combined with iterative structure refinement.
1999 Standout
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
Mechanistic insights into glycosidase chemistry
2008
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Histone lysine demethylases as targets for anticancer therapy
2013
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors
2016
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole
2006
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
The Human Transcription Factors
2018 Standout
A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates
2004 StandoutNobel
β-Galactosidase-instructed formation of molecular nanofibers and a hydrogel
2011
Trapping Covalent Intermediates on β-Glycosidases
2002
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome
2018
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
The role of histone demethylases in cancer therapy
2012
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
2005 StandoutNature
α- and β-Homogalactonojirimycins (α- and β-Homogalactostatins) synthesis and further biological evaluation
2001
Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses
2010
Revealing the human mucinome
2022 StandoutNobel
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
A concise enantioselective synthesis of iminosugar derivatives
2006
Glycosylation in health and disease
2019
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Combinatorial function of transcription factors and cofactors
2017
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases
2012
Synthesis of a Polymer‐Bound Galactosylamine and Its Application as an Immobilized Chiral Auxiliary in Stereoselective Syntheses of Piperidine and Amino Acid Derivatives
2004
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
2013
Regulation of type I interferon responses
2013 Standout
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid
2008
The PI3K Pathway in Human Disease
2017 Standout
Enhancers as non-coding RNA transcription units: recent insights and future perspectives
2016
Proline‐Catalyzed Mannich Reaction of Aldehydes with N‐Boc‐Imines
2006 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
2011 StandoutNobel
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Chemistry of Polyvalent Iodine
2008 Standout
Amino Acid‐Catalyzed Asymmetric Carbohydrate Formation: Organocatalytic One‐Step De Novo Synthesis of Keto and Amino Sugars
2006
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Stereoselective synthesis of azasugars by electrochemical oxidation
2004
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
2010 StandoutNobel
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
Samarium(II)-Iodide-Mediated Cyclizations in Natural Product Synthesis
2004 Standout
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
2015 StandoutNobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Amino acid-catalyzed direct enantioselective synthesis of β-amino-α-oxyaldehydes
2005
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
2013 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides
2010 StandoutScience
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
2016
Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors
2012
Alginate Lyase: Review of Major Sources and Enzyme Characteristics, Structure-Function Analysis, Biological Roles, and Applications
2000
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Synthesis of functionalized nitrogen heterocycles from β- and γ-amino acids by radical decarboxylation
2004
Comprehensive Survey of Combinatorial Library Synthesis: 2005
2006
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Parallel synthesis of homochiral β-amino acids
2007
Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
2013
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
Asymmetric Enamine Catalysis
2007 StandoutNobel
Synthesis and Applications of tert-Butanesulfinamide
2010
New Approach to 1,4‐Benzoxazin‐3‐ones by Electrochemical C−H Amination
2017
Indium(III) triflate catalyzed tandem azidation/1,3-dipolar cycloaddition reaction of ω,ω-dialkoxyalkyne derivatives with trimethylsilyl azide
2005
Works of Tom D. Heightman being referenced
BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes
2013
Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery
2011
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
2014
Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds
2011
Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases
1999
Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
2010
Development of homogeneous luminescence assays for histone demethylase catalysis and binding
2010
Application of an ephedrine chiral linker in a solid-phase, ‘asymmetric catch-release’ approach to γ-butyrolactones
2003
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry
2005
High-resolution native and complex structures of thermostable β-mannanase from Thermomonospora fusca – substrate specificity in glycosyl hydrolase family 5
1998
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
2010
A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases
2011
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction
2014
Terminal Aziridines by α-Deprotonation/Electrophile Trapping of N-Protected Aziridine
2008
Synthesis of Fused Triazoles as Probes for the Active Site of Retaining β‐Glycosidases: From Which Direction Is the Glycoside Protonated?
1996
Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases
1999
A Structural View of the Action ofEscherichia coli(lacZ) β-Galactosidase,
2001
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction
2014
Neue Erkenntnisse über Hemmung, Struktur und Mechanismus konfigurationserhaltender Glycosidasen
1999
Application of a Recyclable Pseudoephedrine Resin in Asymmetric Alkylations on Solid Phase
2004
Evaluation of a Pseudoephedrine Linker for Asymmetric Alkylations on Solid Phase
2002