Standout Papers
Citation Impact
Citing Papers
NSAID use and dementia risk in the Cardiovascular Health Study*
2007
Recognition of the amyloid precursor protein by human γ-secretase
2019 Science
Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
2015
Roles of tau protein in health and disease
2017
Hallmarks of Cancer: The Next Generation
2011 Standout
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
2014
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The amyloid precursor protein: beyond amyloid.
2006
Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
2015
γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
2013
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
2004
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
1999
Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?
2004
Inflammation and Alzheimer's disease
2000 Standout
β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
1995
The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells
2006 StandoutNobel
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
2005
3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate β-Amyloid-Induced Microglial Inflammatory Responses
2005
M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice
2006
The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases
2001
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain
1995
Is there a future for vaccination as a treatment for Alzheimer's disease?
2003
The benefits and limitations of animal models for translational research in neurodegenerative diseases
2010
Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch
2002
Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths
1994
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
2004 Nobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors
1997
Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice
2005
The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
2002
A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques
2004
Aβ Oligomers – a decade of discovery
2007 Standout
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
2006
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
2004
Nuclear Signaling: A Common Function of Presenilin Substrates?
2001
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
2016
Derailed endocytosis: an emerging feature of cancer
2008
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies
2009
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Engineering receptors in the secretory pathway for orthogonal signalling control
2022
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 Standout
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid
1992 Standout
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
2001
Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44
2003
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
2002
Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway
1998
The nanometer-scale structure of amyloid-Β visualized by atomic force microscopy
1996
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
The presenilins and Alzheimer's disease
1997
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
2006
Hydrogen peroxide mediates amyloid β protein toxicity
1994 Standout
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576
2004
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ 42 in humans
2005
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
1992 Nature
Rapid induction of Alzheimer A beta amyloid formation by zinc
1994 Science
BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
2018
Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
1999
Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation
1996
Classification and basic pathology of Alzheimer disease
2009
Novel Class of Polytopic Proteins with Domains Associated with Putative Protease Activity
2002
Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders
2011
Oxidation of Methionine 35 Attenuates Formation of Amyloid β-Peptide 1–40 Oligomers
2002
Notch 1 Signaling Regulates Peripheral T Cell Activation
2004
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein
2002
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
2001
Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?
2006
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor
1993
Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele
2003
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
2008
TREM2 and the neuroimmunology of Alzheimer's disease
2013
Trafficking and Proteolytic Processing of APP
2012
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
2001
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
2018
Role of Endoplasmic Reticulum, Endosomal–Lysosomal Compartments, and Microtubules in Amyloid Precursor Protein Metabolism of Human Neurons
1999
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
2008
Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease
2007
Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles
2006
Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis
1998
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
1995
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
2006
Zinc takes the center stage: its paradoxical role in Alzheimer’s disease
2003
Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
2000
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Decreased β-Amyloid1-42and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer Disease
2003
Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization
1995
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells
1991
Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?
2009
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
2002
Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc
2002
Regulation of lymphocyte development by Notch signaling
2007 StandoutNobel
Biology of Amyloid: Structure, Function, and Regulation
2010
Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
1997
Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide
1995
Notch and the Immune System
2003
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
2018
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Amyloid-β vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
2006
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer’s disease
2002
Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
2006
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
Dysregulated IP3Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca2+Signals and Altered Membrane Excitability
2004
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
The Cellular Phase of Alzheimer’s Disease
2016
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
2006
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
2018
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
2000
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
2010
NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque‐competence, Aβ(1–40)ox and Aβ(1–42)ox
2001 StandoutNobel
Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High‐Affinity Binding Sites in both Cross‐ and Self‐Association
2010
Nicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor
2002
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease
2017
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
Aβ peptides can enter the brain through a defective blood–brain barrier and bind selectively to neurons
2007
Parkinson's disease
2015 Standout
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
The Effect of Aging on the Chaperone Concentrations in the Hepatic, Endoplasmic Reticulum of Male Rats: The Possible Role of Protein Misfolding Due to the Loss of Chaperones in the Decline in Physiological Function Seen With Age
2006
Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments
2000
Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
1996
Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial
2018
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
1999 Nature
Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease
2003
Alzheimer's disease: treatments in discovery and development
2002
A Familial Alzheimer's Disease Locus on Chromosome 1
1995 Science
Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles
2004
The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging
1999
Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
1998
Protein aggregation diseases: pathogenicity and therapeutic perspectives
2010
Chronic nicotine treatment reduces β‐amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
2002
Identification of a novel family of presenilin homologues
2002
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
1995
The Role of Presenilins in γ-Secretase Activity
2001
Regional brain hypometabolism is unrelated to regional amyloid plaque burden
2015
Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
2008
Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains
1996
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease
2016
No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial
2008
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques
1995
Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection
2018
Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
2005
Presenilin/γ-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel β2-Subunit Regulates Cell Adhesion and Migration
2005
Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects
1999
Alzheimer's disease
2006 Standout
Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor
1998
Rapid impact of ?-amyloid on Paxillin in a neural cell line
1997
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
2006
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK
2005
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment
2003
APP Processing and Synaptic Function
2003
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
1993 Standout
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Lessons from a Failed γ-Secretase Alzheimer Trial
2014
Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease<subtitle>A Randomized Controlled Trial</subtitle>
2009
Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models
2006
Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid
2002
Alzheimer's Disease
2010 Standout
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
1993
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations
1988 Nobel
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning
2002
Resolving controversies on the path to Alzheimer's therapeutics
2011
Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
2016
The Amyloid State of Proteins in Human Diseases
2012 Standout
Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice
2006
Familial Danish Dementia
2005
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
2001
Revealing the world of RNA interference
2004 StandoutNatureNobel
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Transgenic mouse brain histopathology resembles early Alzheimer's disease
1994
Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of β-Amyloid Precursor Protein in the Optic Nerve
1995
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
2012
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
2017
Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
2000
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
2011
Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol
1998
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
1989
Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease
2002
Coordination abilities of the 1–16 and 1–28 fragments of β-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study
2003
Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice
2005
Chaperoning Alzheimer's amyloids
1994
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role
2008
Amyloid-beta precursor protein processing in neurodegeneration
2004
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation
2006
The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain
1990
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium
2006
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
1999
The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways
1998
The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease
2004
Amyloid β-peptide is produced by cultured cells during normal metabolism
1992 StandoutNature
Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Aβ42 in response to tunicamycin
2004
Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
1992 Nature
Processing of β-Amyloid Precursor-like Protein-1 and -2 by γ-Secretase Regulates Transcription
2002
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
2009
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
2010
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
2019
Molecular genetics of Alzheimer’s disease
2000
Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage
1989
APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes
2003
Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage
2002
Therapeutic approaches to protein-misfolding diseases
2003 Nature
Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
2015
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005
Self‐oligomerization of NACP, the precursor protein of the non‐amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C‐terminal Aβ fragment (residues 25–35)
1998
Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
2000
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine‐binding domain proteins in the yeast two‐hybrid system
1996
Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)
2003
The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
1995
Notch and Presenilin: a proteolytic mechanism emerges
2001
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
2008
Molecular Mechanisms of Amyloidosis
2003 Standout
Familial Alzheimer disease–linked mutations specifically disrupt Ca2+ leak function of presenilin 1
2007
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
1993 Standout
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch
2001
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
2006
Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum
1994
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease
2016
The molecular pathology of Alzheimer's disease
1991 Standout
A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer’s Disease
2008
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Structural basis of Notch recognition by human γ-secretase
2018 Nature
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
2003
γ-Secretase and its modulators: Twenty years and beyond
2019
Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease
2003
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
2001
Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β
2003
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Framing β–amyloid
1992
EPIDEMIOLOGY OF NEURODEGENERATION
2003
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
2001
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
1997
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
1996 Science
Protective effects of NSAIDs on the development of Alzheimer disease
2008
Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.
1993
Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo
2003
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Active and Passive Immunotherapy for Neurodegenerative Disorders
2008
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
1994
Copper(II)-induced self-oligomerization of α-synuclein
1999
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
2004
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
1988
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
1997
Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia
1997
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis
2012
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates
1990
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
2003
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
1991
Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
2003
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
2006
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
Secretase Targets for Alzheimer's Disease: Identification and Therapeutic Potential
2001
A Century of Alzheimer's Disease
2006 StandoutScience
Accelerated A Deposition in APPswe/PS1 E9 Mice with Hemizygous Deletions of TTR (Transthyretin)
2007
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout
Mutations causing neurodegenerative tauopathies
2004
Secreted Forms of the Amyloid-β Precursor Protein Are Ligands for the Class A Scavenger Receptor
2001
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
2000 Science
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.
1994
DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3
2003
Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies
2008
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
2003
GSK-3 is essential in the pathogenesis of Alzheimer's disease
2006
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing
2002
Amyloid P component. A critical review
1997
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
2019
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
1989
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
2013
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
A Cargo Receptor Mystery APP arently Solved?
2002 Science
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology
2012
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
2017
Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.
1995
C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression
2003
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
2016
Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins
2009
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
2012
The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
1993
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
2001
Alzheimer’s Disease: The Challenge of the Second Century
2011
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
2001 Science
Intraneuronal amyloid‐β1‐42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
2004
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
2010
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease
2005
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Transthyretin sequesters amyloid beta protein and prevents amyloid formation.
1994
The Genetics of the Amyloidoses
2000
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells
1997
Copper inhibits β-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion
1999
Conditional stability of T cells
2010 StandoutNatureNobel
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Trafficking of Cell-Surface β-Amyloid Precursor Protein: Evidence that a Sorting Intermediate Participates in Synaptic Vesicle Recycling
1997
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
2014
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
1996
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
1993
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY
2006
Relation of Neuronal APP-751/APP-695 mRNA Ratio and Neuritic Plaque Density in Alzheimer's Disease
1990 Science
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity
1999
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
1990
Copper(II) complexation by human and mouse fragments (11–16) of β-amyloid peptide
2000
A role for destabilizing amino acid replacements in light-chain amyloidosis.
1994
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Trafficking of cell-surface amyloid β-protein precursor: I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
1996
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production
2008
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
1998
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
2000 Standout
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
1994
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics
2016
Roles for Growth Factors in Cancer Progression
2010
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
2004
Metabolite-initiated protein misfolding may trigger Alzheimer's disease
2004
Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
1997
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
The Development of Amyloid β Protein Deposits in the Aged Brain
2006
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
2001
Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice
2000
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.
2003
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
2002
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
2002
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
2005
Sampling the conformational space of the catalytic subunit of human γ-secretase
2015
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
1993
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
2004
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
2005
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.
1989
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1994
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
2001
Works of Todd E. Golde being referenced
High‐affinity interactions and signal transduction between Aβ oligomers and TREM 2
2018
Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
2008
γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase
2001 Science
IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice
2010
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
2015
Microglia-specific targeting by novel capsid-modified AAV6 vectors
2016
The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
2009
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575
2009
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
2013
γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
2017
β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment
2012
Conformational templating of α-synuclein aggregates in neuronal-glial cultures
2013
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
2002
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain
2010
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
2009
Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition
2001
Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity
2003
Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction
2014
Targeting Aβ and tau in Alzheimer's disease, an early interim report
2009
Quantitative and Mechanistic Studies of Aβ Immunotherapy
2009
A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch
2002
Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
2012
Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities
2000
Immune responses against Aβ1–42 in HLA class II transgenic mice: implications for Aβ1–42 immune-mediated therapies
2003
Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease
2006
Androgens modulate β‐amyloid levels in male rat brain
2003
β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations
2001
Amyloid β protein levels in cerebrospinal fluid are elevated in early‐onset Alzheimer's disease
1994
Safety, Tolerability, Pharmacokinetics, and Aβ Levels After Short-term Administration of R-flurbiprofen in Healthy Elderly Individuals
2007
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
2001 Nature
γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying Length
1999
The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of κB Kinase, and NFκB, Do Not Reduce Amyloid β42 Production
2003
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
2011
Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy
2011
IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior
2015
Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease
2000
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
2015
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study
2006
Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR
1990
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice
2007
A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor
2001
C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation
2005
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
2001
Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice
2005
Secretory processing of the Alzheimer amyloid βA4 protein precursor is increased by protein phosphorylation
1992
The Presenilin 1 C92S Mutation Increases Aβ 42 Production
2000
Serum Amyloid P in Alzheimer's Disease
1991
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
2003 Standout
Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
2013
Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ - Secretase Cleavage
2008
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator
2015
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
2012
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
2001
Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain
2003
Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
2011
Expression of BRI–amyloid β peptide fusion proteins: a novel method for specific high-level expression of amyloid β peptides
2001
Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length
2011
Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis
2013
Alzheimer disease therapy: Can the amyloid cascade be halted?
2003
BRI2 (ITM2b) Inhibits A Deposition In Vivo
2008
Aβ40 Inhibits Amyloid DepositionIn Vivo
2007
Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production
2005
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
2003
Characterization by radiosequencing of the carboxyl-terminal derivatives produced from normal and mutant amyloid β protein precursors
1994
Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice
2003
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
1993 Science
Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle
2002
TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells
2003
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants
1994 StandoutScience
Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease
1988 Science
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity
2008
Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives
1992 Science
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
2009
Familial Frontotemporal Dementia Associated with a Novel Presenilin-1 Mutation
2002
In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimerʼs disease
1988
Cell‐free assays for γ‐secretase activity
2000
Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction
2014
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
1993
Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
2014
Massive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
2009
Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidylinositol kinase inhibitor wortmannin
2000
Nonsteroidal antiinflammatory drugs as therapeutic agents for Alzheimer's disease
2002
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
2005
Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.
1993
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
1996
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
2003
Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor
1992 Science
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
1992 StandoutScience
Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase
2001
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
1988
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.
2003
Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
2005
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
2002
Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo
2013
Alzheimer disease therapy: Can the amyloid cascade be halted?
2003