Standout Papers
Citation Impact
Citing Papers
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly
2005
Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study
2017
Progress and challenges towards targeted delivery of cancer therapeutics
2018 Standout
Heparan Sulfate Glycosaminoglycans Are Receptors Sufficient To Mediate the Initial Binding of Adenovirus Types 2 and 5
2001
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component
2000
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Engineering precision nanoparticles for drug delivery
2020 Standout
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Heparan Sulfate Glycosaminoglycans Are Involved in Adenovirus Type 5 and 2-Host Cell Interactions
2000
Engineering Novel Cell Surface Receptors for Virus-mediated Gene Transfer
1999 StandoutNobel
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Downregulation of CXCR4 Gene Expression in Primary Human Endothelial Cells Following Infection with E1−E4+ Adenovirus Gene Transfer Vectors
2000
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
2013 Standout
Anaplastic lymphoma kinase proteins in growth control and cancer
2004
Structure of the Human Adenovirus Serotype 2 Fiber Head Domain at 1.5 Å Resolution
1999
Endocytosis of adenovirus and adenovirus capsid proteins
2003
Fluorescent Virions: Dynamic Tracking of the Pathway of Adenoviral Gene Transfer Vectors in Living Cells
1998
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Cancer gene therapy: fringe or cutting edge?
2001
Omics-based nanomedicine: The future of personalized oncology
2013
The Hallmarks of Cancer
2000 Standout
Integrins and cancer
1996
Replicative adenoviruses for cancer therapy
2000
Receptors mediating adenovirus attachment and internalization
1999
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
2001
Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells
1999 StandoutNobel
Delivery technologies for cancer immunotherapy
2019 Standout
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
2000 StandoutNobel
The Outer Subventricular Zone and Primate-Specific Cortical Complexification
2015
Microvascular Modifications in Diabetic Retinopathy
2011
The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli
1997
A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry
2010
Engineering targeted viral vectors for gene therapy
2007
Progress and problems with the use of viral vectors for gene therapy
2003 Standout
Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
2008
Dynein- and Microtubule-Mediated Translocation of Adenovirus Serotype 5 Occurs after Endosomal Lysis
2000
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Strong Promoters Are the Key to Highly Efficient, Noninflammatory and Noncytotoxic Adenoviral-Mediated Transgene Delivery into the Brain in Vivo
2000
Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer
2000
Virus-based nanocarriers for drug delivery
2012
Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo
2001
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor
2006
CAR: A virus receptor within the tight junction
2005
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
2001
Nuclear Import and Export of Viruses and Virus Genomes
1998
Cationic Liposomes Enhance Adenovirus Entry via a Pathway Independent of the Fiber Receptor and α v -Integrins
1998
A system for the propagation of adenoviral vectors with genetically modified receptor specificities
1999
Direct Exposure of Mouse Spermatogenic Cells to High Doses of Adenovirus Gene Therapy Vector Does Not Result in Germ Cell Transduction
2000
Lethal Toxicity, Severe Endothelial Injury, and a Threshold Effect with High Doses of an Adenoviral Vector in Baboons
2002
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Adenovirus type 5 and 7 capsid chimera: fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes
1996
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
Nanoparticles in the clinic
2016
The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly
2018
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
2001 Standout
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
1996 Standout
Adding the Third Dimension to Virus Life Cycles: Three-Dimensional Reconstruction of Icosahedral Viruses from Cryo-Electron Micrographs
2000
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Functional rafts in cell membranes
1997 StandoutNature
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
2019
Nanoparticles in the clinic: An update
2019
Chemical Glycobiology
2001 StandoutScienceNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Molecular Biology and Pathogenesis of Viral Myocarditis
2008
A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells
1997
Ketone Isosteres of 2-N-Acetamidosugars as Substrates for Metabolic Cell Surface Engineering
2001 StandoutNobel
Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae.
1996
Cell Surface Engineering by a Modified Staudinger Reaction
2000 StandoutScienceNobel
Adenovirus Core Protein pVII Is Translocated into the Nucleus by Multiple Import Receptor Pathways
2006
Infection of Endothelium With E1 − E4 + , but Not E1 − E4 − , Adenovirus Gene Transfer Vectors Enhances Leukocyte Adhesion and Migration by Modulation of ICAM-1, VCAM-1, CD34, and Chemokine Expression
2001
Neural Science
2000 StandoutNobel
Adding the Third Dimension to Virus Life Cycles: Three-Dimensional Reconstruction of Icosahedral Viruses from Cryo-Electron Micrographs
1999
Transfer of Genes to Humans: Early Lessons and Obstacles to Success
1995 Science
Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob
1998
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
1997 StandoutScience
Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation
2002 StandoutNobel
DNA Genome Size Affects the Stability of the Adenovirus Virion
2008
DNA vaccines: an historical perspective and view to the future
2010
Fiber and Penton Base Capsid Modifications Yield Diminished Adenovirus Type 5 Transduction and Proinflammatory Gene Expression with Retention of Antigen-Specific Humoral Immunity
2006
Science and technology for water purification in the coming decades
2008 StandoutNature
A new adenoviral helper–dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo
2002
Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA
1994
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector
2000
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Viral Vectors for Gene Therapy
1998
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli
1994 Nobel
High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells
1998
Subgroup B and F Fiber Chimeras Eliminate Normal Adenovirus Type 5 Vector Transduction In Vitro and In Vivo
2002
High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells
1998
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2
1994
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
Surface molecular recognition
2001 StandoutNobel
Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time
1996
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Thomas J. Wickham being referenced
CAR-dependent and CAR-independent pathways of adenovirus vector–mediated gene transfer and expression in human fibroblasts
1999
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity
2012
Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin (MM-302) Demonstrates Synergistic Antitumor Activity in Breast and Gastric Cancer
2016
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
2017
Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin
1999
Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types
1996
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
1993 Standout
Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein
1999
Polylysine Modification of Adenoviral Fiber Protein Enhances Muscle Cell Transduction
1999
A gradient-loadable 64Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography
2014
Comparative recombinant protein production of eight insect cell lines
1993
Adenoviral vectors for gene transfer
1997
Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models
2000
Ligand-directed targeting of genes to the site of disease
2003
Targeting endothelium for gene therapy via receptors up-regulated during angiogenesis and inflammation
1997
The Role of Capsid–Endothelial Interactions in the Innate Immune Response to Adenovirus Vectors
2003
Reducing the Native Tropism of Adenovirus Vectors Requires Removal of both CAR and Integrin Interactions
2001
Targeted adenovirus-mediated gene delivery to T cells via CD3
1997
The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses
1998
A phase I study of MM-302, a HER2-targeted liposomal doxorubicin, in patients with advanced, HER2-positive (HER2+) breast cancer.
2012
Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
1999 Science
Mutations in the DG Loop of Adenovirus Type 5 Fiber Knob Protein Abolish High-Affinity Binding to Its Cellular Receptor CAR
1999
Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment
1996
Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.
2001
Modification to the Capsid of the Adenovirus Vector That Enhances Dendritic Cell Infection and Transgene-Specific Cellular Immune Responses
2004
Adenovirus Binding to the Coxsackievirus and Adenovirus Receptor or Integrins Is Not Required To Elicit Brain Inflammation but Is Necessary To Transduce Specific Neural Cell Types
2002
Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies
1996
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
1997
The Coxsackievirus-Adenovirus Receptor Protein Can Function as a Cellular Attachment Protein for Adenovirus Serotypes from Subgroups A, C, D, E, and F
1998
Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs.
1995
Adenovirus Type 9 Fiber Knob Binds to the Coxsackie B Virus-Adenovirus Receptor (CAR) with Lower Affinity than Fiber Knobs of Other CAR-Binding Adenovirus Serotypes
2001
Abstract P5-18-09: A Phase I Study of MM-302, a HER2-targeted Liposomal Doxorubicin, in Patients with Advanced, HER2- Positive Breast Cancer
2012
Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.
1994
Multiple adenovirus serotypes use alpha v integrins for infection
1994