Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease
2010 StandoutScience
Notch Inhibits Expression of the Kruppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium
2008
NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
2010 StandoutNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
2010 StandoutNobel
Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
2010
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
2005
Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
2010
The COX-2 Selective Inhibitor-Independent COX-2 Effect on Colon Carcinoma Cells is Associated with the Delta1/Notch1 Pathway
2008
Notch Signaling Promotes the Generation of EphrinB1-Positive Intestinal Epithelial Cells
2009
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2
2008 StandoutNobel
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
2008
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
2013
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides
2003
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
Acute lymphoblastic leukaemia
2008
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]
2005
Efficient four‐drug cocktail therapy targeting amyloid‐β peptide for Alzheimer's disease
2010
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
2013
Cancer Metastasis: Building a Framework
2006 Standout
T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling
2004
Transition-metal mediated carbon–sulfur bond activation and transformations
2012 Standout
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
2005
Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
2011
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
2008 Standout
The Cancer Genome Atlas Pan-Cancer analysis project
2013 Standout
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
2006 StandoutNobel
Inflammatory bowel disease: cause and immunobiology
2007 Standout
Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells
2005
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Transgenic models of Alzheimer’s disease: Learning from animals
2005
Protein aggregation diseases: pathogenicity and therapeutic perspectives
2010
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
2012 Standout
Alzheimer's disease
2006 Standout
Alzheimer's disease
2016 Standout
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
2006 Nature
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Catalytic asymmetric synthesis of chromenes and tetrahydroquinolines via sequential allylic alkylation and intramolecular Heck coupling
2012 StandoutNobel
Alzheimer's Disease
2010 Standout
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
2005 Nature
The Amyloid State of Proteins in Human Diseases
2012 Standout
Size Effect of Graphene Oxide on Modulating Amyloid Peptide Assembly
2015
Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation
2004
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Amyloid-beta precursor protein processing in neurodegeneration
2004
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
2011 Standout
Wnt signalling in stem cells and cancer
2005 StandoutNature
Notch: Architect, Landscaper, and Guardian of the Intestine
2011 Standout
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
2012
Development of intestinal M cells
2005
Tumor Angiogenesis
2008 Standout
Notch and T cell malignancy
2004
A γ‐secretase inhibitor decreases amyloid‐β production in the central nervous system
2009
Safety, Tolerability, and Changes in Amyloid β Concentrations After Administration of a γ-Secretase Inhibitor in Volunteers
2005
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Modeling Development and Disease with Organoids
2016 Standout
γ-Secretase and its modulators: Twenty years and beyond
2019
Intramembrane Proteolysis
2009
The Golden Age of Transfer Hydrogenation
2015 Standout
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications
2016 Standout
Ruthenium(II) Complexes Bearing a Pyridyl-Supported Pyrazolyl−N-Heterocyclic Carbene (NNC) Ligand and Their Catalytic Activity in the Transfer Hydrogenation of Ketones
2008
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
2008
Phenotypic characterization of human colorectal cancer stem cells
2007 Standout
Diversity-Oriented Synthesis of 2,4,6-Trisubstituted Piperidines via Type II Anion Relay Chemistry
2011
Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development
2012 StandoutNobel
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines
2012 Standout
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Mitsunobu and Related Reactions: Advances and Applications
2009
Phosphine Organocatalysis
2018 Standout
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Self-Renewal and Cancer of the Gut: Two Sides of a Coin
2005 Science
N-Heterocyclic Carbenes in Late Transition Metal Catalysis
2009 Standout
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease
2006
Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine
2005
Concise Review: Notch Signaling in Stem Cell Systems
2006
Cancer Genome Landscapes
2013 StandoutScience
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Direct regulation of intestinal fate by Notch
2005
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
Prospects for the Future
2002 StandoutScienceNobel
Works of Thomas Bara being referenced
Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse
2006
Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease
2006
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
2004
Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
2007
Tetrahydroquinoline sulfonamides as γ-secretase inhibitors
2006
Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity
2002