Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
The DNA-damage response in human biology and disease
2009 StandoutNature
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
1999 StandoutNobel
Regulation of p53 stability by Mdm2
1997 StandoutNature
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
p53: traffic cop at the crossroads of DNA repair and recombination
2005
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
p53 in growth control and neoplasia
1996
Bone marrow cells regenerate infarcted myocardium
2001 StandoutNature
Cell-cycle checkpoints and cancer
2004 StandoutNature
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
1995
p53, the Cellular Gatekeeper for Growth and Division
1997 Standout
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Genetic instabilities in human cancers
1998 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
2010 StandoutNature
When Checkpoints Fail
1997 StandoutNobel
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1996 StandoutNature
The spindle assembly checkpoint
1996
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases
1995 Nature
The Hallmarks of Cancer
2000 Standout
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
1997
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
Control of apoptosis and mitotic spindle checkpoint by survivin
1998 StandoutNature
Dissecting p53 tumor suppressor functions in vivo
2002
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
Regulation of the p53 Tumor Suppressor Protein
1999
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
1998
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
1996 Nature
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
A model for p53-induced apoptosis
1997 StandoutNature
Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
1995
Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM
1995
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
1999
Clonal evolution in cancer
2012 StandoutNature
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities
1998 Standout
A microRNA polycistron as a potential human oncogene
2005 StandoutNature
p53 in signaling checkpoint arrest or apoptosis
1996
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Barrett's esophagus: Cell cycle abnormalities in advancing stages of neoplastic progression
1993
p53; from inductive signal to cellular effect
1997
The cancer genome
2009 StandoutNature
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.
1996
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Pacing-Induced Heart Failure in Dogs Enhances the Expression of p53 and p53-Dependent Genes in Ventricular Myocytes
1998
Ubiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation
1997
Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
2002
Quality Control by DNA Repair
1999 StandoutScienceNobel
Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
2012
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
2000
Cancer Cell Cycles
1996 StandoutScience
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control
1998
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption
1998
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Surfing the p53 network
2000 StandoutNature
Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma.
1993
Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption
1996 Science
Cancer Genome Landscapes
2013 StandoutScience
Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability
1997
Inactivation of G2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6.
1997
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Abnormal Centrosome Amplification in the Absence of p53
1996 Science
Selectively Advantageous Mutations and Hitchhikers in Neoplasms
2004
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Development of Apoptosis and Polyploidy in Human Lymphoblast Cells as a Function of Position in the Cell Cycle at the Time of Irradiation
1996
Identification and classification of p53-regulated genes
1999
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage
1998
Works of Stig Ramel being referenced
Barrett's Esophagus: A Model of Human Neoplastic Progression
1994
Evaluation of p53 protein expression in Barrett's esophagus by two-parameter flow cytometry
1992
17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma.
1991
A p53-Dependent Mouse Spindle Checkpoint
1995 Science