Citation Impact
Citing Papers
Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
2004 Science
Structural basis for ligand promiscuity in cytochrome P450 3A4
2006
Sparse bursts optimize information transmission in a multiplexed neural code
2018
Copper-free click chemistry in living animals
2010 StandoutNobel
Protein stability promotes evolvability
2006 StandoutNobel
Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
2016
Evolutionary History of a Specialized P450 Propane Monooxygenase
2008 StandoutNobel
Protein engineering of oxygenases for biocatalysis
2002 StandoutNobel
Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Is Important in Induction of Drug-Specific T-Cell Responses in Vivo
2008
Molecular, pharmacological and functional diversity of 5-HT receptors
2002 Standout
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans
2016
Chiral Recognition in Bis-Urea-Based Aggregates and Organogels through Cooperative Interactions
2001 StandoutNobel
Functional study of rat 5‐HT2A receptors using antisense oligonucleotides
2003
Backpropagation and the brain
2020 StandoutNobel
A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze
2001
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
2007 StandoutNobel
Selection of boron reagents for Suzuki–Miyaura coupling
2013 Standout
Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
2003 StandoutNobel
Libraries of hybrid proteins from distantly related sequences
2001 StandoutNobel
Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment
2004
Catalytic Assays for Human Cytochrome P450
2003
A Self‐Sufficient Peroxide‐Driven Hydroxylation Biocatalyst
2003 StandoutNobel
Chiral separation of amino acids and peptides by capillary electrophoresis
2000
Highly Efficient and Regioselective Platinum(II)‐Catalyzed Tandem Synthesis of Multiply Substituted Indolines and Tetrahydroquinolines
2009
Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR
2009
The Serotonin Syndrome
2005 Standout
Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging
2016
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
2010 StandoutNobel
5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
2001
P450 BM3: the very model of a modern flavocytochrome
2002
Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue
2000
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The ChEMBL database in 2017
2016 Standout
P450BM-3 and other Inducible Bacterial P450 Cytochromes: Biochemistry and Regulation
1991
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
2007
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
2010
A Novel Sterol 14α-Demethylase/Ferredoxin Fusion Protein (MCCYP51FX) from Methylococcus capsulatusRepresents a New Class of the Cytochrome P450 Superfamily
2002
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Purification and Mechanism of Human Aldehyde Oxidase Expressed in Escherichia coli
2009
Asymmetric Multicomponent Reactions (AMCRs): The New Frontier
2005 Standout
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands
2005
The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human
2012
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
The determination and interpretation of the therapeutic index in drug development
2012
Use of Density Functional Calculations To Predict the Regioselectivity of Drugs and Molecules Metabolized by Aldehyde Oxidase
2007
3d Transition Metals for C–H Activation
2018 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Biologically active quinoline and quinazoline alkaloids part I
2017
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
2002 Standout
2-Substituted Tryptamines: Agents with Selectivity for 5-HT6Serotonin Receptors
2000
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety
2010 Standout
Tuning P450 Enzymes as Oxidation Catalysts
2012
Preparative Microfluidic Electrosynthesis of Drug Metabolites
2013
Mitsunobu and Related Reactions: Advances and Applications
2009
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Accessing Drug Metabolites via Transition‐Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
2016
Homologation of the Fischer Indolization: A Quinoline Synthesis via Homo‐Diaza‐Cope Rearrangement
2020 StandoutNobel
Phosphine Organocatalysis
2018 Standout
Rh‐Catalyzed Direct Amination of Unactivated C(sp3)−H bond with Anthranils Under Mild Conditions
2016
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology
2003
ProTox-II: a webserver for the prediction of toxicity of chemicals
2018 Standout
Spectroscopic and Electronic Structure Studies Probing Covalency Contributions to C–H Bond Activation and Transition-State Stabilization in Xanthine Oxidase
2011
PubChem 2023 update
2022 Standout
In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450
2017
Chimeric Antigen Receptor Therapy
2018 Standout
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Role of the Molybdoflavoenzyme Aldehyde Oxidase Homolog 2 in the Biosynthesis of Retinoic Acid: Generation and Characterization of a Knockout Mouse
2008
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods
2019 Standout
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6Receptor Ligands
2004
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
The Mononuclear Molybdenum Enzymes
2014 Standout
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
2011
5-ht6 Receptors as Emerging Targets for Drug Discovery
2000
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Heme-Containing Oxygenases
1996 Standout
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery
2000
Transition-metal-free approach to synthesis of indolines from N-(ortho-chloromethyl)aryl amides and iodonium ylides
2013
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Structure and Chemistry of Cytochrome P450
2005 Standout
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Stephen E. Clarke being referenced
Managing the challenge of chemically reactive metabolites in drug development
2011
CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators
1997
Feedback Synthesizes Neural Codes for Motion
2017
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
2001
Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes
1994
Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
2002
Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist
2000
Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein
2001
Cytochrome P-450 in the housefly: Induction, substrate specificity and comparison to three rat hepatic isoenzymes
1989
6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist
1997
In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.
1997
Micellar electrokinetic capillary chromatography in a mixture of taurodeoxycholic acid and β-cyclodextrin
1992
Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling
2007
Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds
2012
Aldehyde Oxidase-catalysed Oxidation of Methotrexate in the Liver of Guinea-pig, Rabbit and Man
1999
Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.
2001
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT6 Receptor Antagonist
1999
Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac
2004