Citation Impact
Citing Papers
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
2008
BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
2010 Science
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
2011
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
2009 Nature
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)
2008
Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
2009
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
2009
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development
2008
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
2010 Science
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
2013
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
2009 Standout
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis
2009
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
2009
To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
2008
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma
2013
Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
2005
Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic
2012
Transcriptional regulation of memory B cell differentiation
2020
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
How the Bcl-2 family of proteins interact to regulate apoptosis
2006
Dissecting p53-dependent apoptosis
2006
BH3‐ligand regulates access of MCL‐1 to its E3 ligase
2005
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
2012
Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in Cancer
2005
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
2007
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
2012
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
2007
Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
2009
Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
2013
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
2013
BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
2010
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
Combining immunotherapy and targeted therapies in cancer treatment
2012
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
A Stapled BID BH3 Helix Directly Binds and Activates BAX
2006
Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
2009
Pharmacological manipulation of cell death: clinical applications in sight?
2005
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
2008
The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL
2009
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
Cancer drug resistance: an evolving paradigm
2013 Standout
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
2008
Pharmacological manipulation of Bcl-2 family members to control cell death
2005
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
2009
The Beclin 1 interactome
2010
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
2005
BCL-2 family proteins: changing partners in the dance towards death
2017
BCL-2 family antagonists for cancer therapy
2008
Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis
2005
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
2007
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations
2007
Structure-Based Redesign of the Binding Specificity of Anti-Apoptotic Bcl-xL
2012
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
2010
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
2010
The structure of Boo/Diva reveals a divergent Bcl-2 protein
2010
Apoptosis: embedded in membranes
2010
Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas
2007
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
BAX activation is initiated at a novel interaction site
2008 Nature
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Bcl‐2 changes conformation to inhibit Bax oligomerization
2006
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis
2006 StandoutNobel
Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
2009
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
2006
Mitochondrial dynamics and apoptosis
2008
Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist
2007
Cell Death
2009
Programmed Anuclear Cell Death Delimits Platelet Life Span
2007
Regulation of memory B and plasma cell differentiation
2017
Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces
2010
A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak
2007
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
2011
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology
2012
Protein binding specificity versus promiscuity
2010
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Functional characterization of the Bcl-2 gene family in the zebrafish
2006
Caspase-independent cell death
2005
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
2012
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
2009
PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors
2018
The Transcriptional Regulation of Germinal Center Formation
2018
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
2008
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
2007 Standout
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
2005
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax
2007
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
2007
Structurally Distinct Phosphatases CD45 and CD148 Both Regulate B Cell and Macrophage Immunoreceptor Signaling
2008
Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
2008
Delving deeper: MCL-1's contributions to normal and cancer biology
2012
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
2013
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
2012
Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
2011
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The anatomical and cellular basis of immune surveillance in the central nervous system
2012
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
2012
The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site
2006
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Hallmarks of Aging
2013 Standout
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
2006
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
2008
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
2013
Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion
2009
Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis
2006
Mechanisms of Action of Bcl-2 Family Proteins
2013
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
2006
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
2012
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
The BCL-2 Family Reunion
2010
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
2011
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
2009
Mcl‐1; the molecular regulation of protein function
2010
VDAC2 is required for truncated BID‐induced mitochondrial apoptosis by recruiting BAK to the mitochondria
2009
Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
2011
From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display
2013
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
2007
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Structural insights into the degradation of Mcl-1 induced by BH3 domains
2007
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
2008
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
2011 Science
Molecular biology of Bax and Bak activation and action
2010
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
2013
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
2010
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
2010
Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity
2012
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
2016 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help
2017
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
2005 Science
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
2008
Germinal Centers
2012
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo
2005
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
2006
Direct activation of full-length proapoptotic BAK
2013
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
2012
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
2006
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
2013
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
An Adenosine Triphosphatase of the Sucrose Nonfermenting 2 Family, Androgen Receptor-Interacting Protein 4, Is Essential for Mouse Embryonic Development and Cell Proliferation
2007
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release
2008
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis
2006
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
2006
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Zinc finger–IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell
2018
Newcomers in the process of mitochondrial permeabilization
2005
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
2007
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
2007
Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation
2007
The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation
2005
Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x-deficient Mice
2008
Differential Effects of β3‐ versus β2‐Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3‐Derived α/β‐Peptides
2018
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
2010
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
2012
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
2011
Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
2011
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
2009
Works of Simon N. Willis being referenced
The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response
2009
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
2011
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
2015
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
2007
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
2005
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
2005
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
2017
Life in the balance: how BH3-only proteins induce apoptosis
2005
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
2007 Science
The Bcl-2-regulated apoptotic pathway
2003
The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
2014
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell–Intrinsic Mechanism
2014
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008