Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
A comprehensive map of human glucokinase variant activity
2023
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2012 StandoutNobel
In situ click chemistry generation of cyclooxygenase-2 inhibitors
2017 Standout
The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins
2000 StandoutNobel
A Primer on Vesicle Budding
1999 StandoutNobel
Molecular Characterization of the GTPase-activating Domain of ADP-ribosylation Factor Domain Protein 1 (ARD1)
1998
Molecular and cellular regulation of human glucokinase
2019
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes
2004 StandoutNobel
Snapshots of ARF1
1999
Different Domains of Mammalian ADP-ribosylation Factor 1 Mediate Interaction with Selected Target Proteins
1997
GTPase activation of elongation factor EF‐Tu by the ribosome during decoding
2009 StandoutNobel
Structural and Biochemical Properties Show ARL3-GDP as a Distinct GTP Binding Protein
2000
β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis
2001 StandoutNobel
New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
2011 StandoutNobel
Iterative In Situ Click Chemistry Creates Antibody‐like Protein‐Capture Agents
2009 StandoutNobel
Structural insights into cognate versus near‐cognate discrimination during decoding
2011 StandoutNobel
Crystal Structure of Intact Elongation Factor EF-Tu from Escherichia coli in GDP Conformation at 2.05Å Resolution
1999
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Click Chemistry and Medicinal Chemistry: A Case of “Cyclo‐Addiction”
2008
The 1.14 Å Crystal Structure of Yeast Cytosine Deaminase
2003
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Structural Basis for Activation of ARF GTPase
1998
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
2002 StandoutNobel
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport
1999 Nature
An α to β conformational switch in EF-Tu
1996
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Helix unwinding in the effector region of elongation factor EF-Tu–GDP
1996
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models
2007
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6
2000 StandoutNobel
Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
2006 StandoutNobel
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry
2009 StandoutNobel
Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta
1999
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta -phosphate to destabilize GDP on ARF1
1998
Putative Reaction Intermediates in Crm1-mediated Nuclear Protein Export
1999 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms
2010 StandoutNobel
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
New insights into the kinetic target-guided synthesis of protein ligands
2015
On the Mechanism of Hydrolysis of Phosphate Monoesters Dianions in Solutions and Proteins
2006 StandoutNobel
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
2009 StandoutNobel
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles
1998 StandoutNobel
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export
2001
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
fw2.2 : A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size
2000 StandoutScience
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system
2015
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
In situclick chemistry: a powerful means for lead discovery
2006 StandoutNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation
1998 StandoutNobel
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides
2005 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of S.E. Greasley being referenced
Insights into Mechanism of Glucokinase Activation
2012
Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery
2011
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
2001
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms
1995
Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase,
2001
New Insights into Inhibitor Design from the Crystal Structure and NMR Studies ofEscherichia coliGAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid,
1999