Citation Impact
Citing Papers
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease
2022
Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation
2013
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review
2009
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
2016
Inflammation and metabolic disorders
2006 StandoutNature
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
2007 Standout
Adverse Health Effects of Marijuana Use
2014 Standout
Evaluating triggers and enhancers of tau fibrillization
2005
TRPV1: a therapeutic target for novel analgesic drugs?
2006
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 Standout
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
2012
Alzheimer's disease
2011 Standout
Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring
2013
Developing new metal-based therapeutics: challenges and opportunities
2007
Central Sensitization and CaVα2δ Ligands in Chronic Pain Syndromes: Pathologic Processes and Pharmacologic Effect
2010
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Effect of Morphine and Pregabalin Compared With Diphenhydramine Hydrochloride and Placebo on Hyperalgesia and Allodynia Induced by Intradermal Capsaicin in Healthy Male Subjects
2008
Central sensitization: Implications for the diagnosis and treatment of pain
2010 Standout
Pathological pain and the neuroimmune interface
2014
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007 Standout
Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins
2004
Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells
2004
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: Influence of low and high formalin concentrations
2009
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Transient receptor potential channels as therapeutic targets
2011
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
2007
Glia and pain: Is chronic pain a gliopathy?
2013
The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins
1995
Tau-aggregation inhibitor therapy for Alzheimer's disease
2013
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice
2014
The TRPV1 receptor and nociception
2006
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
2011
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial
2011
Alzheimer's disease
2016 Standout
Translating nociceptive processing into human pain models
2009
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
The role of the immune system in the generation of neuropathic pain
2012
Alzheimer's Disease
2010 Standout
Tau oligomers and aggregation in Alzheimer’s disease
2009
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Regulation of chromatin structure by site-specific histone H3 methyltransferases
2000 StandoutNature
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
2014
Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers
2006
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers †
2007
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease
2000
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
The Hyperglycemia-induced Inflammatory Response in Adipocytes
2004
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
2011 StandoutNobel
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
1993 Standout
TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
2009 StandoutNobel
The molecular pathology of Alzheimer's disease
1991 Standout
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain
2011
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease
2018
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds1This manuscript summarizes the presentation given at the symposium ‘Biological Aspects of Vanadium Chemistry — Chemistry, Biochemistry and Therapeutic Applications of Vanadium Compounds’ and recently communicated in original research articles. The original research articles describing the experimental details of this work are given in Refs: [1–5].1
2000
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Dose-dependent Effects of Smoked Cannabis on Capsaicin-induced Pain and Hyperalgesia in Healthy Volunteers
2007
Intrinsic disorder in proteins associated with neurodegenerative diseases
2009
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
2018
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
1993 Standout
Pathways of tau fibrillization
2004
TRP Channels and Pain
2013 StandoutNobel
Developmental control of a G1-S transcriptional program in Drosophila
1994
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage
2014 Standout
Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane
2003
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle
1994
Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
2003
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
BACE inhibitors in clinical development for the treatment of Alzheimer’s disease
2018
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
1993 Standout
Targeting TRPV1 for pain relief: limits, losers and laurels
2012
Works of Robert Lai being referenced
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
2021
Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes
2001
Enhanced Sensitivity of Insulin-resistant Adipocytes to Vanadate Is Associated with Oxidative Stress and Decreased Reduction of Vanadate (+5) to Vanadyl (+4)
2001
Quantitative analysis of tau protein in paired helical filament preparations: Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease
1995
Modulation of insulin action by vanadate: evidence of a role for phosphotyrosine phosphatase activity to alter cellular signaling
1995
Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody
2016
Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
2011
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
2007
O1‐06‐05: First‐in‐human study of E2609, a novel BACE1 inhibitor, demonstrates prolonged reductions in plasma beta‐amyloid levels after single dosing
2012
Chronic Oral Gabapentin Reduces Elements of Central Sensitization in Human Experimental Hyperalgesia
2004
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
1996
S4‐04‐01: CSF amyloid lowering in human volunteers after 14 days’ oral administration of the novel BACE1 inhibitor E2609
2012
Blocking cell division does not remove the requirement for Polycomb function in Drosophila embryogenesis
1990
702 A RANDOMISED, TWO‐PERIOD CROSS‐OVER STUDY TO INVESTIGATE THE EFFICACY OF THE TRPV1 ANTAGONIST SB‐705498 IN ACUTE MIGRAINE
2009
Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer’s Disease
2016
Examination of phosphorylated tau protein as a PHF-precursor at early stage alzheimer's disease
1995
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2006