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Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
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Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
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The Cerebrocortical Areas in Normal Brain Aging and in Alzheimer's Disease: Noticeable Differences in the Lipid Peroxidation Level and in Antioxidant Defense
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A Lipid Peroxidation-derived Inflammatory Mediator
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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
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Molecular Functionalization of Carbon Nanotubes and Use as Substrates for Neuronal Growth
2000
CD44: From adhesion molecules to signalling regulators
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1999
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
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Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
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1994
Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein
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Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons
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The Expression of Key Oxidative Stress-Handling Genes in Different Brain Regions in Alzheimer's Disease
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Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
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Hypothesis: Proteasomal Dysfunction
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ApoE protects cortical neurones against neurotoxicity induced by the non‐fibrillar C‐terminal domain of the amyloid‐β peptide
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A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
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Co-culture with astrocytes or microglia protects metabolically impaired neurons
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Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide
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β‐Amyloid inhibits integrated mitochondrial respiration
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2001
The Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells
1999
Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease
1999
Role of Free Radicals in the Neurodegenerative Diseases
2001 Standout
17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron
1997
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Mitochondrial DNA damage and repair in neurodegenerative disorders
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Chapter 3 Properties and localization of glutamate transporters
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System Xc−and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40
2006
A network dysfunction perspective on neurodegenerative diseases
2006 Nature
Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide
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Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
1998
Regional Membrane Phospholipid Alterations in Alzheimer's Disease
1998
Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease
1998
Brain metabolism and brain disease: Is metabolic deficiency the proximate cause of Alzheimer dementia?
2001
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
2001
4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes
1998
The Functional and Neuroprotective Actions of Neu2000, a Dual-Acting Pharmacological Agent, in the Treatment of Acute Spinal Cord Injury
2009
Prediction of the structure of symmetrical protein assemblies
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Apoptosis in Neurological Disease
1998
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
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2001
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
1999
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.
1995
The Free Radical Theory of Aging Matures
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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2000 StandoutScience
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Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
ALS-Linked Cu/Zn-SOD Mutation Impairs Cerebral Synaptic Glucose and Glutamate Transport and Exacerbates Ischemic Brain Injury
2000
Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction
1998
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity
2000
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
1987 StandoutNobel
Mechanism of Oxidative Stress in Neurodegeneration
2012
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Multifunctional Activities of Green Tea Catechins in Neuroprotection
2005
In VivoImaging of Reactive Oxygen Species Specifically Associated with Thioflavine S-Positive Amyloid Plaques by Multiphoton Microscopy
2003
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.
2002
Immune reactivity in a mouse model of familial ALS correlates with disease progression
2001
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity
1999
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
2011
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Interfacing Carbon Nanotubes with Living Cells
2006 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
2004
The role of oxidative damage in the neuropathology of organic acidurias: Insights from animal studies
2004
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways
1995
Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.
1996
Works of Robert J. Mark being referenced
4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake
1997
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
1997
Inflammatory Cytokines Enhance Muscarinic‐Mediated Arachidonic Acid Release Through p38 Mitogen‐Activated Protein Kinase in A2058 Cells
2000
Aβ25–35 induces rapid lysis of red blood cells: contrast with Aβ1–42 and examination of underlying mechanisms
1997
Anticonvulsants attenuate amyloid β-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology
1995
Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease
1996
Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea
1996
Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons
1997
Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease
1997
Characterization of 8‐Epiprostaglandin F2α as aMarker of Amyloid β‐Peptide‐Induced Oxidative Damage
1999
A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide
1997
Lysophosphatidic Acid Induces Necrosis and Apoptosis in Hippocampal Neurons
1998
Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells
1997
Fibroblast growth factor-8 protects cultured rat hippocampal neurons from oxidative insult
1999
Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture
1995
Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Hippocampus: Modulation of Expression by Seizures and Anti-Excitotoxic Action
1999
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
1997
4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gαq/11
1997
Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways
1997
Common mechanisms of oxidative damage in chronic neurodegenerative conditions: potential points of therapeutic intervention
1999