Citation Impact
Citing Papers
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Methylation determines fibroblast activation and fibrogenesis in the kidney
2010
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Molecular Determinants of Permeation through the Cation Channel TRPV4
2002
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
The role of calmodulin for inositol 1,4,5-trisphosphate receptor function
2002
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
2005
Calcium signalling: dynamics, homeostasis and remodelling
2003 Standout
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
2017 Nature
TRP channels and lipids: from Drosophila to mammalian physiology
2006
Transient receptor potential channelopathies
2010
Dawning of a new era in TRP channel structural biology by cryo-electron microscopy
2018
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
Cellular pathophysiology of ischemic acute kidney injury
2011 Standout
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
2008
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins
2005
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
2003 Standout
Intrinsic Epithelial Cells Repair the Kidney after Injury
2008
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
2000 Nature
Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2
2018
Acute Renal Failure
1996 Standout
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Polycystin-2 Is a Novel Cation Channel Implicated in Defective Intracellular Ca2+ Homeostasis in Polycystic Kidney Disease
2001
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
1998 Standout
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
2009
Disruption of a Novel Imprinted Zinc-Finger Gene, ZNF215, in Beckwith-Wiedemann Syndrome
2000
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM
2017
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice
2002
Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
2002 Standout
Transport Function of the Naturally Occurring Pathogenic Polycystin-2 Mutant, R742X
2001
The genetics and physiology of polycystic kidney disease
2001
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
2014
Constitutive Activation of G-proteins by Polycystin-1 Is Antagonized by Polycystin-2
2002
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Mechanisms of ischemic acute renal failure
1993
Polycystin
2001
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure
2003
Bone marrow stem cells contribute to repair of the ischemically injured renal tubule
2003
Cloning of the Gene Encoding a Novel Integral Membrane Protein, Mucolipidin—and Identification of the Two Major Founder Mutations Causing Mucolipidosis Type IV
2000
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
2011
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
WHSC1, a 90 kb SET Domain-Containing Gene, Expressed in Early Development and Homologous to a Drosophila Dysmorphy Gene Maps in the Wolf-Hirschhorn Syndrome Critical Region and is Fused to IgH in t(1;14) Multiple Myeloma
1998
Human TRPML1 channel structures in open and closed conformations
2017 NatureNobel
Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy
2011
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Dedifferentiation and Proliferation of Surviving Epithelial Cells in Acute Renal Failure
2003
Relationship between Expression of Bcl-2 Genes and Growth Factors in Ischemic Acute Renal Failure in the Rat
2000
Ciliar functions in the nephron
2009
Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced
1995
Sensing with TRP channels
2005
Kidney tubular epithelium is restored without replacement with bone marrow–derived cells during repair after ischemic injury
2005
TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca2+ and cell volume
2015
Biomarkers for epithelial-mesenchymal transitions
2009 Standout
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Calcium Signalling: More Messengers, More Channels, More Complexity
2002
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury
1998
The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
2016
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
2001 Nature
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant
2002
Prevention of Kidney Ischemia/Reperfusion-induced Functional Injury, MAPK and MAPK Kinase Activation, and Inflammation by Remote Transient Ureteral Obstruction
2002
Transforming growth factor-β in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
2004
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
2017
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion
1997
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
2013
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
The ion selectivity filter is not an activation gate in TRPV1-3 channels
2019
Phenotypic consequences of lung-specific inducible expression of FGF-3
2001 StandoutNobel
A regulatory system for target gene expression
1998
PERMEATION AND SELECTIVITY OF TRP CHANNELS
2005
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
2015 StandoutNobel
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
The TRP Superfamily of Cation Channels
2005
Molecular Structure and Physiological Function of Chloride Channels
2002
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Polycystin 1 is required for the structural integrity of blood vessels
2000
Expression of fibronectin splice variants in the postischemic rat kidney
2001
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
Mammalian ABC Transporters in Health and Disease
2002
ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells
1998
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca 2+ -permeable nonselective cation channel
2000
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney
1998
Acute renal failure. I. Relative importance of proximal vs. distal tubular injury
1998
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Tetracycline-Reversible Silencing of Eukaryotic Promoters
1995
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia
1999
Genomic analysis of orthologous mouse and human olfactory receptor loci
2001 StandoutNobel
Diversity in unconventional protein secretion
2012
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Krüppel-associated boxes are potent transcriptional repression domains.
1994
A novel RU486 inducible system for the activation and repression of genes
1998
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Biomarkers of Acute Kidney Injury
2007
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
2018
Renal Cyst Development in Mice with Conditional Inactivation of the von Hippel-Lindau Tumor Suppressor
2006
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Polycystin channels and kidney disease
2001
TRP Channels
2007 Standout
Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure
2000
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Ca2+ Regulation of TRP Ion Channels
2018
Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia
1999 StandoutNobel
Works of Ralph Witzgall being referenced
An ever-expanding story of cyst formation
2000
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.
1994 Standout
Cytosolic Phospholipase A2 (PLA2), but Not Secretory PLA2, Potentiates Hydrogen Peroxide Cytotoxicity in Kidney Epithelial Cells
1996
The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells.
1998
Polycystin-2 is an intracellular calcium release channel
2002
Identification and Characterization of Polycystin-2, thePKD2 Gene Product
1999
Ca2+-dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2
2009
ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel
2009
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
2017
A Truncated Polycystin-2 Protein Causes Polycystic Kidney Disease and Retinal Degeneration in Transgenic Rats
2006
Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury.
1993
Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia
1998
The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.
1994
Kid-1, a kidney transcription factor.
1995
Kid-1, a Putative Renal Transcription Factor: Regulation during Ontogeny and in Response to Ischemia and Toxic Injury
1993
Polycystin-2 takes different routes to the somatic and ciliary plasma membrane
2011
The rat Pkd2 protein assumes distinct subcellular distributions in different organs
1999
A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins
1996
Calmodulin‐dependent activation of the epithelial calcium‐dependent chloride channel TMEM16A
2010
Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.
1997
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
2000
Differentiation and cell polarity during renal cyst formation in the Han:SPRD (cy/+) rat, a model for ADPKD
1997