Standout Papers

From the Triumvirate to the Ominous Octet: A N... 1992 2026 2003 2014 2.1k
  1. From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus (2009)
    Ralph A. DeFronzo Diabetes
  2. Pathogenesis of NIDDM: A Balanced Overview (1992)
    Ralph A. DeFronzo, Riccardo C. Bonadonna et al. Diabetes Care
  3. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role ofPGC1andNRF1 (2003)
    Mary‐Elizabeth Patti, Atul J. Butte et al. Proceedings of the National Academy of Sciences
  4. Type 2 diabetes mellitus (2015)
    Ralph A. DeFronzo, Ele Ferrannini et al. Nature Reviews Disease Primers
  5. Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009)
    Ralph A. DeFronzo, Devjit Tripathy Diabetes Care
  6. The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization (1981)
    Ralph A. DeFronzo, E Jacot et al. Diabetes
  7. A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis (2006)
    Renata Belfort, Stephen A. Harrison et al. New England Journal of Medicine
  8. Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes (2005)
    Ralph A. DeFronzo, Robert E. Ratner et al. Diabetes Care
  9. Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus (1995)
    Ralph A. DeFronzo, A. Goodman New England Journal of Medicine
  10. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. (1985)
    Ralph A. DeFronzo, Rebeqa Gunnarsson et al. Journal of Clinical Investigation
  11. Pharmacologic Therapy for Type 2 Diabetes Mellitus (1999)
    Ralph A. DeFronzo Annals of Internal Medicine
  12. Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle (2000)
    Kenneth Cusi, Katsumi Maezono et al. Journal of Clinical Investigation
  13. Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes (2015)
    Melanie J. Davies, Richard M. Bergenstal et al. JAMA
  14. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013)
    Melania Gaggini, Mariangela Morelli et al. Nutrients
  15. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production (2014)
    Aurora Merovci, Carolina Solis‐Herrera et al. Journal of Clinical Investigation
  16. Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose (2006)
    Muhammad Abdul-Ghani, Devjit Tripathy et al. Diabetes Care
  17. Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients (2002)
    Yoshinori Miyazaki, Archana Mahankali et al. The Journal of Clinical Endocrinology & Metabolism
  18. Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans (2004)
    John M. Adams, Thongchai Pratipanawatr et al. Diabetes
  19. Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin (1979)
    Ralph A. DeFronzo Diabetes
  20. Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man (1983)
    Ralph A. DeFronzo, Eleuterio Ferrannini et al. Diabetes
  21. Renal, metabolic and cardiovascular considerations of SGLT2 inhibition (2016)
    Ralph A. DeFronzo, Luke Norton et al. Nature Reviews Nephrology
  22. Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors (2021)
    Ralph A. DeFronzo, William Reeves et al. Nature Reviews Nephrology
  23. The effects of glucose and insulin on renal electrolyte transport. (1976)
    Ralph A. DeFronzo, Matthew S. Goldberg et al. Journal of Clinical Investigation

Immediate Impact

20 from Science/Nature 132 standout
Sub-graph 1 of 16

Citing Papers

The integrative biology of type 2 diabetes
2019 StandoutNature
Mechanisms, Pathophysiology, and Management of Obesity
2017 Standout
50 intermediate papers

Works of Ralph A. DeFronzo being referenced

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes
2015 Standout
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
2009 Standout
and 41 more

Author Peers

Author Last Decade Papers Cites
Ralph A. DeFronzo 23648 20450 17277 411 50.5k
Ele Ferrannini 28308 14917 11541 523 50.0k
Ralph A. DeFronzo 18905 13264 11642 282 37.6k
Steven E. Kahn 20367 12423 13019 467 45.2k
Gerald M. Reaven 29768 13376 18678 663 58.0k
Jerrold M. Olefsky 15228 34169 24518 588 70.4k
Markku Laakso 22794 15999 13178 667 56.6k
C. Ronald Kahn 13599 36433 26211 511 73.3k
Bart Staels 12793 40867 17854 781 77.2k
Oluf Pedersen 12555 17825 11409 702 42.4k
Roger H. Unger 13138 11070 11236 407 35.4k

All Works

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