Citation Impact
Citing Papers
TRP channel activation by reversible covalent modification
2006 StandoutNobel
The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
2009
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Regulation of intracellular heme trafficking revealed by subcellular reporters
2016
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
2017
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria
2009
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
HIF-2α, but not HIF-1α, promotes iron absorption in mice
2009
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study
2010
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
The heme oxygenase system and cellular defense mechanisms
2001
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia
2017
Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis
2009
NMDA Receptor-Nitric Oxide Transmission Mediates Neuronal Iron Homeostasis via the GTPase Dexras1
2006
Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin
1989
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element
1997
Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis
2012
Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death
2002
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis
2006
Identification of a Human Heme Exporter that Is Essential for Erythropoiesis
2004
Iron and copper metabolism
2005
Iron Overload Cardiomyopathy
2010
The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells
1999
Control of intracellular heme levels: Heme transporters and heme oxygenases
2011
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function
2010
Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-Δ12,14-prostaglandin J2-induced heme oxygenase-1 expression
2004
A Mammalian Siderophore Synthesized by an Enzyme with a Bacterial Homolog Involved in Enterobactin Production
2010
Haem oxygenase-1 prevents cell death by regulating cellular iron
1999
Balancing Acts
2004 Standout
Mechanism of Heme Oxygenase-1 Gene Induction by Quercetin in Rat Aortic Smooth Muscle Cells
2004
A Mammalian Iron ATPase Induced by Iron
2000
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
2010
Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis
2018 StandoutNobel
The First Cellular Models Based on Frataxin Missense Mutations That Reproduce Spontaneously the Defects Associated with Friedreich Ataxia
2009
The Molecular Circuitry Regulating the Switch between Iron Deficiency and Overload in Mice
2006
NMR Structure of the Heme Chaperone CcmE Reveals a Novel Functional Motif
2002
Hepcidin and iron homeostasis
2012
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells
2000
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Macrophages and Systemic Iron Homeostasis
2012
Role of the Ferroportin Iron-Responsive Element in Iron and Nitric Oxide Dependent Gene Regulation
2002
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Transferrin Receptor Induction by Hypoxia
1999
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
2008 Nature
Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock
2001
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
2001 Standout
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
2012
Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells
2004
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
2000
Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery
2009
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
2005
A Red Carpet for Iron Metabolism
2017
Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency
2000
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
1993 StandoutNobel
Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia
2013
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
2005
HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation
1999
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
2007
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
Neurodegenerative diseases and oxidative stress
2004 Standout
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
2002 Standout
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
2014
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Perspectives on Oxygen Sensing
1999 StandoutNobel
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
2004
The power plant of the cell is also a smithy: The emerging role of mitochondria in cellular iron homeostasis
2008
One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans
2012
Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics
2011
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
Friedreich's Ataxia, No Changes in Mitochondrial Labile Iron in Human Lymphoblasts and Fibroblasts
2004
Early Embryonic Lethality of H Ferritin Gene Deletion in Mice
2000
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation
2003
The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1
2004
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
2005
Regulating the fate of mRNA: The control of cellular iron metabolism
1993
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
2008
Oxygen homeostasis
2009 StandoutNobel
Protein S-nitrosylation: purview and parameters
2005 Standout
Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models
2004
Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development
2010
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
2010
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Hypoxia affects mesoderm and enhances hemangioblast specification during early development
2004
Transferrin receptor 1 in cancer: a new sight for cancer therapy.
2018
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Adenovirus-Mediated Heme Oxygenase-1 Gene Transfer Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice
2001
Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors
2009
Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice
2004
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis
2010
IRON REGULATORY PROTEINS AND THE MOLECULAR CONTROL OF MAMMALIAN IRON METABOLISM
2000
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Acquisition of iron from transferrin regulates reticulocyte heme synthesis.
1985
Novel di-2-pyridyl–derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment
2004
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity
2010
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
2012
Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles
2003
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
2005
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
The cancer connection
2002 StandoutNatureNobel
Macrophages and iron trafficking at the birth and death of red cells
2015
Thiosemicarbazones: The New Wave in Cancer Treatment
2009
Mutation in the Fe–S scaffold protein Isu bypasses frataxin deletion
2011
Heme and the Endothelium
1998
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria
2014
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Novel “hybrid” iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells
2002
Systemic Iron Homeostasis
2013
Unusual Heme−Histidine Bond in the Active Site of a Chaperone
2005
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
2005
Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway
1998
ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin
2018
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Expression of alternative transcripts of ferroportin-1 during human erythroid differentiation.
2005
Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis
2010
Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
2005
Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
2012
Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network
2008
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
2007
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond
2006
Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity
2006
Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity
2010
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
2005
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
1991
Works of Prem Ponka being referenced
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
2006
Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes
2011
Cell Biology of Heme
1999
Nramp1 equips macrophages for efficient iron recycling
2008
Hereditary Causes of Disturbed Iron Homeostasis in the Central Nervous System
2004
Development of potential iron chelators for the treatment of Friedreich’s ataxia: ligands that mobilize mitochondrial iron
2001
Do Mammalian Cells Really Need to Export and Import Heme?
2017
Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction
1995
Iron Overload in Human Disease
2012
Rare causes of hereditary iron overload
2002
Nitric Oxide-Mediated Modulation of Iron Regulatory Proteins: Implication for Cellular Iron Homeostasis
2002
Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling
2010
Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture
1992
The long history of iron in the Universe and in health and disease
2011
Pyridoxal Isonicotinoyl hydrazone and its analogues
2002
Non-heme Induction of Heme Oxygenase-1 Does Not Alter Cellular Iron Metabolism
2007
The anemia of “haemoglobin-deficit” (hbd/hbd) mice is caused by a defect in transferrin cycling
2006
Identification of a Hypoxia Response Element in the Transferrin Receptor Gene
1999
Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2
1999
Mitochondrial Iron Metabolism and Sideroblastic Anemia
2009
Effects of Interferon-γ and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2
2000
Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes
1988
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
1997
Erythroid cell mitochondria receive endosomal iron by a “kiss-and-run” mechanism
2016
Overexpression of Mitochondrial Ferritin Sensitizes Cells to Oxidative Stress Via an Iron-Mediated Mechanism
2009
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia
2012
Iron trafficking in the mitochondrion: novel pathways revealed by disease
2004
Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism
1996
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents
1995
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant
2009
S-Nitrosylation of IRP2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway
2003
Partition coefficients of the iron(III) complexes of pyridoxal isonicotinoyl hydrazone and its analogs and the correlation to iron chelation efficacy
1995
Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes
1988
Identification of an Erythroid Active Element in the Transferrin Receptor Gene
2000
Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells
1997
Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis
2004
Control of heme synthesis during Friend cell differentiation: Role of iron and transferrin
1986
The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation
2008
Hepcidin, the hormone of iron metabolism, is bound specifically to α-2-macroglobulin in blood
2009
Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells
1997
Hypoxia. 5. Hypoxia and hematopoiesis
2011
Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells
2003
Direct interorganellar transfer of iron from endosome to mitochondrion
2007
Expression of ferrochelatase mRNA in erythroid and non-erythroid cells
1993
Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria
2004
Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
2005
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo
2009
Transferrin and iron uptake by human lymphoblastoid and K-562 cells
1981
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin
2006
The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis.
1994
Function and regulation of transferrin and ferritin.
1998
Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization
2002
Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis
2002
Direct Interorganellar Transfer of Iron from Endosome to Mitochondrion.
2006
Cell Biology of Heme
1999
Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice
2001
Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron
1999
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
2010
The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells
1995