Citation Impact
Citing Papers
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
GeneChip ® expression analysis of the iron starvation response in Pseudomonas aeruginosa : identification of novel pyoverdine biosynthesis genes
2002
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Novel therapeutic strategies targeting HIV integrase
2012
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
2013
Switchable Cas9
2017 StandoutNobel
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
2012
Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors
2009
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
2017 Standout
New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond
2015
Bacterial iron homeostasis
2003 Standout
Necroptosis and its role in inflammation
2015 StandoutNature
Changes of Intestinal Functions in Liver Cirrhosis
2016 Standout
Gut microbiota functions: metabolism of nutrients and other food components
2017 Standout
Tissue-specific actions of FXR in metabolism and cancer
2014
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
2010
Siderophores of the Pseudomonadaceae sensu stricto(Fluorescent and Non-Fluorescent Pseudomonas spp.)
2004
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
2007 StandoutNobel
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors
2009
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
2010
Bile acids and nonalcoholic fatty liver disease
2016
The molecular machinery of regulated cell death
2019 Standout
Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum
2011
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
2015
Pharmacological agents for NASH
2013
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Metastasis suppressors in breast cancers: mechanistic insights and clinical potential
2013
Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
2018 Standout
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Catechol‐Based Biomimetic Functional Materials
2012
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
2014 Standout
The use of spirocyclic scaffolds in drug discovery
2014 Standout
New and unusual scaffolds in medicinal chemistry
2011
A fast screening method for the identification of siderophores from fluorescentPseudomonas spp. by liquid chromatography/electrospray mass spectrometry
1999
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity
2016
FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease
2015
Recognition of the DNA minor groove by pyrrole-imidazole polyamides
2003
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
2016 Standout
New developments in the discovery of small molecule Hedgehog pathway antagonists
2010
Gut microbiota, metabolites and host immunity
2016 Standout
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
2009
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
2015 Standout
Mitochondria as multifaceted regulators of cell death
2019 Standout
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
2016 Standout
Chemistry and biology of siderophores
2010 Standout
Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
2012
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
2017
Bile acid receptors as targets for drug development
2013
Bile acids: emerging role in management of liver diseases
2015
The integrated stress response
2016 Standout
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease
2023 Standout
3d Transition Metals for C–H Activation
2018 Standout
Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles
2013 Standout
Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions
2011 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides
2016
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Assessing Molecular Docking Tools for Relative Biological Activity Prediction: A Case Study of Triazole HIV-1 NNRTIs
2013
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities
2021
Butyrate Histone Deacetylase Inhibitors
2012
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
2015 Standout
Nucleophilic difluoromethylation and trifluoromethylation using tetrakis(dimethylamino)ethylene (TDAE) reagent
2008
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
2014 Standout
Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products
2013 Standout
Rh-Catalyzed N–O Bond Cleavage of Anthranil: A C–H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group
2016
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Destabilizing Domains Derived from the Human Estrogen Receptor
2012
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
2018 Standout
Organokatalytische Synthese von enantiomerenreinen 2H‐ und 3H‐Pyrrolen: Inhibitoren des Hedgehog‐Signalwegs
2016 StandoutNobel
Regioselective Functionalization of the Imidazole Ring via Transition Metal‐Catalyzed CN and CC Bond Forming Reactions
2010
A general strategy to construct small molecule biosensors in eukaryotes
2015 StandoutNobel
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Synthesis and Applications of tert-Butanesulfinamide
2010
Polyfunctional Tetrazolic Thioethers through Electrooxidative/Michael-Type Sequential Reactions of 1,2- and 1,4-Dihydroxybenzenes with 1-Phenyl-5-mercaptotetrazole
2008
PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
2013
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Works of Olaf Kinzel being referenced
FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model
2012
A practical approach to the synthesis of hairpin polyamide–peptide conjugates through the use of a safety-catch linker
2002
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists
2010
Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities
2014
Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice
2012
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—A new class of HIV-1 integrase inhibitors
2009
Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant
2006
A Functionally Orthogonal Estrogen Receptor-Based Transcription Switch Specifically Induced by a Nonsteroid Synthetic Ligand
2005
The Synthesis and Antibacterial Activity of two Pyoverdin-ampicillin Conjugates, Entering Pseudomonas aeruginosa via the Pyoverdin-mediated Iron Uptake Pathway.
1998
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway
2009
Synthesis and biological evaluation of a pyoverdin‐β‐lactam conjugate: a new type of arginine‐specific cross‐linking in aqueous solution
1999
Nonsteroidal FXR Ligands: Current Status and Clinical Applications
2019
A Structure-Guided Approach to an Orthogonal Estrogen-Receptor-Based Gene Switch Activated by Ligands Suitable for in Vivo Studies
2006
Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties
2009
A general approach to homochiral α-amino substituted bromo-heteroaromatics suitable for two-dimensional rapid analogue synthesis
2009
Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors
2008
A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo
2008
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors
2008
266 FXR DIRECTLY CONTROLS THE TUMOR SUPPRESSOR NDRG2 AND FXR AGONISTS REDUCE TUMOR GROWTH AND METASTASIS IN AN ORTHOTOPIC XENOGRAFT MOUSE MODEL
2012
The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors
2007