Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
PD-L1 Expression in Triple-Negative Breast Cancer
2014
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
2004
Identification of Multiple Mechanisms of Resistance to Vemurafenib in a Patient with BRAFV600E-Mutated Cutaneous Melanoma Successfully Rechallenged after Progression
2013
Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter
2004 StandoutNobel
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate
2005
Cancer Metastasis: Building a Framework
2006 Standout
Cancer drug resistance: an evolving paradigm
2013 Standout
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis
2004
Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
2005
Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes
2007
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
2002 StandoutScience
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
2007 Standout
Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines
2003
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.
2001
Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II
2002 StandoutNobel
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
2005
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
The Multiple Roles of PTEN in Tumor Suppression
2000
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
2005
Fibronectin, integrins, and growth control
2001
Functional roles of Akt signaling in mouse skin tumorigenesis
2002
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
The microenvironment of the tumour–host interface
2001 StandoutNature
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
2003
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Cisplatin induces PKB/Akt activation and p38MAPK phosphorylation of the EGF receptor
2006
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
The Hepatitis C Virus NS5A Protein Activates a Phosphoinositide 3-Kinase-dependent Survival Signaling Cascade
2004
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Integrins
2002 Standout
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005
Biological aspects of signal transduction by cell adhesion receptors
2002
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
The MAPK pathway across different malignancies: A new perspective
2014 Standout
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
2002
Regulator of G Protein Signaling Proteins: Novel Multifunctional Drug Targets
2001
Fluorogenic Phospholipid Substrate to Detect Lysophospholipase D/Autotaxin Activity
2006
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600–Mutant Colorectal Cancer
2015
Trk Receptors: Roles in Neuronal Signal Transduction
2003 Standout
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules
2013
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
2007 Standout
Cancer Genome Landscapes
2013 StandoutScience
The Developmental Biology of Brain Tumors
2001
The Pim kinases control rapamycin-resistant T cell survival and activation
2005
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer
2018 Standout
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten+/−mice
2001
Works of Muling Mao being referenced
Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
2012
Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase
2001
Enhancement of Phototransduction G Protein-Effector Interactions by Phosphoinositides
2004
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
1999
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
1999
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
1999
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells
2000
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells
2000
Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer
2000