Standout Papers
- RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes (2017)
- Programmable RNA recognition and cleavage by CRISPR/Cas9 (2014)
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection (2016)
- RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a (2018)
- Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme (2017)
- Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes (2015)
- Programmable RNA Tracking in Live Cells with CRISPR/Cas9 (2016)
Citation Impact
Citing Papers
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 StandoutNobel
CRISPR/Cas9 in Genome Editing and Beyond
2016
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
2019 StandoutNobel
Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28
2017
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a
2017
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence
2019 StandoutNobel
CRISPR-Based Technologies: Impact of RNA-Targeting Systems
2018
Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System
2018
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
A scoutRNA Is Required for Some Type V CRISPR-Cas Systems
2020 StandoutNobel
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9
2017
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a
2017
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein
2018
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
2017
Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci
2016
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
2016
A CRISPR toolbox to study virus–host interactions
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Diversity, classification and evolution of CRISPR-Cas systems
2017
Enabling functional genomics with genome engineering
2015
Controlling and enhancing CRISPR systems
2020 StandoutNobel
An Introduction to Biological NMR Spectroscopy
2013
Diversity and evolution of class 2 CRISPR–Cas systems
2017
A decade of discovery: CRISPR functions and applications
2017
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
SHERLOCK: nucleic acid detection with CRISPR nucleases
2019
RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System
2017 StandoutNobel
RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems
2018
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
2016
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
2015
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
2019 StandoutNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
2017
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Staphylococcus aureus Cas9 is a multiple-turnover enzyme
2018
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells
2020
Protein Engineering of Cas9 for Enhanced Function
2014
The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR–Cas subtype III-Bv system
2018
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
2017 Nature
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish
2020
A prudent path forward for genomic engineering and germline gene modification
2015 StandoutScienceNobel
Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease
2019
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
2018 StandoutScience
A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity
2020 Science
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Genomic Engineering and the Future of Medicine
2015 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Diagnosing COVID-19: The Disease and Tools for Detection
2020 Standout
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
2015
Multicolor CRISPR labeling of chromosomal loci in human cells
2015
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Applications of CRISPR/Cas9 in the Mammalian Central Nervous System.
2017
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system
2019
Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay
2020
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
2016
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells
2015
Functionally diverse type V CRISPR-Cas systems
2018 Science
Works of Mitchell R. O’Connell being referenced
RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a
2018 StandoutNobel
Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme
2017 StandoutNobel
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
2017 StandoutNobel
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes
2015 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems
2018
The structural analysis of protein–protein interactions by NMR spectroscopy
2009