Standout Papers
- The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation (1975)
- Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes. (1977)
- The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH (1975)
- The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation (1975)
- Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate. (1977)
- The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP. (1979)
- Selective effects of organic mercurials on the GTP-regulatory proteins of adenylate cyclase systems. (1980)
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Agonist-Specific Effects of Guanine Nucleotides on Alpha-Adrenergic Receptors in Human Platelets
1979 StandoutNobel
A Quantitative Analysis of Beta-Adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data
1980 StandoutNobel
Mechanism of Activation of Cholera Toxin by ADP-Ribosylation Factor (ARF): Both Low- and High-Affinity Interactions of ARF with Guanine Nucleotides Promote Toxin Activation
1990
The Role of GTP-Binding Proteins in Signal Transduction: From the Sublimely Simple to the Conceptually Complex
1992 StandoutNobel
Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation
2000 StandoutNobel
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons
1989 StandoutNatureNobel
The β3-Adrenergic Receptor Activates Mitogen-activated Protein Kinase in Adipocytes through a Gi-dependent Mechanism
1999
Development and Validation of Real-Time Quantitative Reverse Transcriptase–Polymerase Chain Reaction for Monitoring Gene Expression in Cardiac Myocytesin Vitro
1999
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Differential Regulation by Guanine Nucleotides of Opiate Agonist and Antagonist Receptor Interactions
1980
Molecular mechanisms involved in α-adrenergic responses
1981
ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase
1979 StandoutNatureNobel
Inhibitory effect of guanyl nucleotides toward adenylate cyclase activity of Chinese hamster ovary cell membranes activated in vitro by cholera toxin.
1979
Homologies Between Signal Transducing G Proteins and ras Gene Products
1984 StandoutScienceNobel
Inhibition and activation of fat cell adenylate cyclase by GTP is mediated by structures of different size
1980 StandoutNobel
Alpha-Adrenergic Receptor Subtypes
1980 StandoutNobel
Simple model for hormone-activated adenylate cyclase systems.
1976 StandoutNobel
Characteristics of the guanine nucleotide regulatory component of adenylate cyclase in human erythrocyte membranes
1980 StandoutNobel
Molecular Mechanisms of Coupling in Hormone Receptor‐Adenylate Cyclase Systems
1982 StandoutNobel
Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.
1977
Regulation of platelet adenylate cyclase by adenosine
1979
Effects of phospholipase A2 and filipin on the activation of adenylate cyclase
1979 StandoutNobel
Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes
1978
Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.
1984
Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
1983
Agonist versus antagonist binding to alpha-adrenergic receptors.
1980 StandoutNobel
Proteolysis activates adenylate cyclase in rat liver and AC− lymphoma cell independently of the guanine nucleotide regulatory site
1980 StandoutNobel
Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.
1978 StandoutNobel
Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.
1980 StandoutNobel
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.
1982 StandoutNobel
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
1980 StandoutNatureNobel
Octyl glucoside extracts GTP-binding regulatory proteins from rat brain "synaptoneurosomes" as large, polydisperse structures devoid of beta gamma complexes and sensitive to disaggregation by guanine nucleotides.
1990 StandoutNobel
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.
1982 StandoutNobel
GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes.
1977 StandoutNobel
The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue
1979
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.
1980 StandoutNobel
Pertussis toxin induces structural changes in G alpha proteins independently of ADP-ribosylation.
1989 StandoutNobel
Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling
1981
Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.
1978
Guanyl nucleotide influences on 3H-ligand binding to alpha-noradrenergic receptors in calf brain membranes.
1978
The hamster adipocyte adenylate cyclase system I. Regulation of enzyme stimulation and inhibition by manganese and magnesium ions
1981
Evidence for two alpha-adrenergic binding sites in liver plasma membranes. Studies with [3H]epinephrine and [3H]dihydroergocryptine.
1979
Structure of the turkey erythrocyte adenylate cyclase system.
1981 StandoutNobel
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.
1976 StandoutNobel
Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides
1980 StandoutNatureNobel
Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.
1983 StandoutNobel
The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.
1993 StandoutNobel
Activation of the hepatic adenylate cyclase system by divalent cations.
1977
GTP-binding proteins in membranes and the control of adenylate cyclase activity.
1977
Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes
1976
Limited proteolysis eliminates guanine nucleotide inhibition of choleragen-activated adenylate cyclase. Possible basis for proteolytic stimulation of cyclic AMP production.
1980
Subclasses of external adenosine receptors.
1980
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.
1983 StandoutNobel
Purification of the regulatory component of adenylate cyclase.
1980 StandoutNobel
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
1977 StandoutNobel
Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme.
1979
Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.
1979 StandoutNobel
Molecular Cloning of Complementary DNA for the Alpha Subunit of the G Protein that Stimulates Adenylate Cyclase
1985 StandoutScienceNobel
Catecholamine binding to CNS adrenergic receptors
1978
Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.
1978
The requirement of guanine nucleotides for glucagon stimulation of adenylate cyclase in rat liver plasma membranes.
1977
Guanosine 5'-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions.
1979
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Evidence for distinct guanine nucleotide sites in the regulation of the glucagon receptor and of adenylate cyclase activity.
1977 StandoutNobel
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
1984
Inhibition of adenylate cyclase by hormones and neurotransmitters
1979
Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an “excited” state of GTPase is a control component of the system.
1977 StandoutNobel
Adenosine receptors: Clinical implications and biochemical mechanisms
1988
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Cholera toxin modifies diverse GTP-modulated regulatory proteins
1981 StandoutNobel
Evidence for specific binding sites for guanine nucleotides in adipocyte and hepatocyte plasma membranes. A difference in fate of GTP and guanosine 5'-(beta, gamma-imino) triphosphate.
1975 StandoutNobel
On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones.
1975 StandoutNobel
The characteristics of lubrol-solubilized adenylate cyclase from rat liver plasma membranes
1978 StandoutNobel
Isoproterenol stimulates shift of G proteins from plasma membrane to pinocytotic vesicles in rat adipocytes: a possible means of signal dissemination.
1990 StandoutNobel
Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.
1977 StandoutNobel
Functional Desensitisation of β‐Adrenergic Receptors of Avian Erythrocytes by Catecholamines and Adenosine 3′,5′‐Phosphate
1980
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
1984 StandoutNobel
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
1988 StandoutNobel
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.
1978 StandoutNobel
Agonist-induced increase in apparent β-adrenergic receptor size
1978 StandoutNobel
Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.
1979
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Guanine nucleotides distinguish between two dopamine receptors
1979 Nature
Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition.
1982 StandoutNobel
Neurohypophyseal hormone-responsive renal adenylate cyclase. IV. A random-hit matrix model for coupline in a hormone-sensitive adenylate cyclase system.
1978
Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states.
1977 StandoutNobel
Works of Ming‐Chih Lin being referenced
Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.
1995
The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation
1975 StandoutNobel
The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation
1975 StandoutNobel
Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes.
1977 StandoutNobel
Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate.
1977 StandoutNobel
Reduction of GTP activation of adenylate cyclase system by its coupling to hormone receptor.
1979
The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.
1979 StandoutNobel
NAD glycohydrolase and ADP-ribosyltransferase activities are intrinsic to the A1 peptide of choleragen.
1979
The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH
1975 StandoutNobel