Michael Zientek

Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics

Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways

PharmGKB summary

Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo

The ChEMBL database in 2017

The role of drug metabolizing enzymes in clearance

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Novel Bayesian classification models for predicting compounds blocking hERG potassium channels

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization

Human immunodeficiency virus 1 downregulates cell surface expression of the non-classical major histocompatibility class I molecule HLA-G1

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

Insights into Molecular Basis of Cytochrome P450 Inhibitory Promiscuity of Compounds

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

Phosphine Organocatalysis

An Easy, Stereoselective Synthesis of Hexahydroisoindol‐4‐ones under Phosphine Catalysis

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential

Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase

Characterization of endothelin converting enzyme from intact cells of a permanent human endothelial cell line EA.hy926

Identification of Novel Substrates for Human Cytochrome P450 2J2

Integrated in Silico−in Vitro Strategy for Addressing Cytochrome P450 3A4 Time-Dependent Inhibition

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats