Standout Papers

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular dom... 1999 2026 2008 2017 1.7k
  1. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain (1999)
    Bart De Strooper, Wim Annaert et al. Nature
  2. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity (1999)
    Michael S. Wolfe, Weiming Xia et al. Nature
  3. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma (2006)
    Andrew P. Weng, John M. Millholland et al. Genes & Development
  4. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 (2003)
    W. Taylor Kimberly, Matthew J. LaVoie et al. Proceedings of the National Academy of Sciences

Immediate Impact

14 by Nobel laureates 46 from Science/Nature 106 standout
Sub-graph 1 of 15

Citing Papers

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
2018 Standout
100 intermediate papers

Works of Michael S. Wolfe being referenced

Presenilin: Running with Scissors in the Membrane
2007
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
and 43 more

Author Peers

Author Last Decade Papers Cites
Michael S. Wolfe 8114 8040 2588 165 14.3k
Wim Annaert 6453 7032 1691 137 12.6k
Koji Takio 4070 13302 775 195 20.5k
Jason E. Gestwicki 2141 10599 785 223 14.5k
Harvey B. Pollard 2945 8878 768 293 14.1k
Gloria Lee 5141 6139 885 125 12.5k
Anthony H. Futerman 6286 12653 769 277 18.0k
Hiroyoshi Hidaka 1938 9286 821 326 14.2k
Mikael Simons 3995 12688 604 141 20.4k
Kun Ping Lu 2740 17205 691 205 20.8k
Per Westermark 9118 15286 429 359 22.7k

All Works

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2026