Standout Papers

A Receptor-Mediated Pathway for Cholesterol Homeostasis 1979 2026 1994 2010 4.4k
  1. A Receptor-Mediated Pathway for Cholesterol Homeostasis (1986)
    Michael S. Brown, Joseph L. Goldstein Science
  2. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (2002)
    Jay D. Horton, Joseph L. Goldstein et al. Journal of Clinical Investigation
  3. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (2002)
    Jay D. Horton, Joseph L. Goldstein et al. Journal of Clinical Investigation
  4. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition (1979)
    Joseph L. Goldstein, Y K Ho et al. Proceedings of the National Academy of Sciences
  5. LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis (1983)
    Michael S. Brown, Joseph L. Goldstein Annual Review of Biochemistry
  6. Coated pits, coated vesicles, and receptor-mediated endocytosis (1979)
    Joseph L. Goldstein, Richard G.W. Anderson et al. Nature
  7. [19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells (1983)
    Joseph L. Goldstein, Sandip K. Basu et al. Methods in enzymology on CD-ROM/Methods in enzymology
  8. Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System (1985)
    Joseph L. Goldstein, Michael S. Brown et al. PubMed
  9. Protein Sensors for Membrane Sterols (2006)
    Joseph L. Goldstein, Russell A. DeBose‐Boyd et al. Cell
  10. Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts (1974)
    Joseph L. Goldstein, Michael S. Brown Journal of Biological Chemistry
  11. The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA (1984)
    Tokuo Yamamoto, Christopher G. Davis et al. Cell
  12. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes (2003)
    Jay D. Horton, Nila Shah et al. Proceedings of the National Academy of Sciences
  13. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood (1999)
    Michael S. Brown, Joseph L. Goldstein Proceedings of the National Academy of Sciences
  14. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. (1976)
    S K Basu, J L Goldstein et al. Proceedings of the National Academy of Sciences
  15. The LDL Receptor (2009)
    Joseph L. Goldstein, Michael S. Brown Arteriosclerosis Thrombosis and Vascular Biology
  16. Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone (2008)
    Jing Yang, Michael S. Brown et al. Cell
  17. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia (1992)
    Helen H. Hobbs, Michael S. Brown et al. Human Mutation
  18. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis (1994)
    Xiaodong Wang, Ryuichiro Sato et al. Cell
  19. Crucial Step in Cholesterol Homeostasis (2002)
    Tong Yang, Peter J. Espenshade et al. Cell
  20. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy (1999)
    Iichiro Shimomura, Robert E. Hammer et al. Nature
  21. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene (1993)
    Chieko Yokoyama, Xiaodong Wang et al. Cell
  22. A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015)
    Joseph L. Goldstein, Michael S. Brown Cell
  23. Regulation of Plasma Cholesterol by Lipoprotein Receptors (1981)
    Michael S. Brown, Petri T. Kovanen et al. Science
  24. Receptor-Mediated Control of Cholesterol Metabolism (1976)
    Michael S. Brown, Joseph L. Goldstein Science
  25. Selective versus Total Insulin Resistance: A Pathogenic Paradox (2008)
    Michael S. Brown, Joseph L. Goldstein Cell Metabolism
  26. The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins (1985)
    Thomas C. Südhof, Joseph L. Goldstein et al. Science
  27. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides (1990)
    Yuval Reiss, Joseph L. Goldstein et al. Cell
  28. Recycling receptors: The round-trip itinerary of migrant membrane proteins (1983)
    Michael S. Brown, Richard G.W. Anderson et al. Cell
  29. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes (1999)
    Iichiro Shimomura, Yuriy K. Bashmakov et al. Proceedings of the National Academy of Sciences
  30. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. (1980)
    Michael S. Brown, Y K Ho et al. Journal of Biological Chemistry
  31. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy (1998)
    Iichiro Shimomura, Robert E. Hammer et al. Genes & Development
  32. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. (1994)
    Shun Ishibashi, Joseph L. Goldstein et al. Journal of Clinical Investigation
  33. Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans (1976)
    Joseph L. Goldstein, Sandip K. Basu et al. Cell
  34. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts (1977)
    Richard G.W. Anderson, Michael S. Brown et al. Cell
  35. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis (2010)
    Shijie Li, Michael S. Brown et al. Proceedings of the National Academy of Sciences
  36. Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c (2002)
    Guosheng Liang, Jian Yang et al. Journal of Biological Chemistry
  37. Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts (1981)
    Sandip K. Basu, Joseph L. Goldstein et al. Cell
  38. THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein (1990)
    Helen H. Hobbs, David W. Russell et al. Annual Review of Genetics
  39. Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells (1993)
    Guy L. James, Joseph L. Goldstein et al. Science
  40. Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol (2009)
    Hyock Joo Kwon, Lina Abi-Mosleh et al. Cell
  41. HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions (1984)
    Gary A. Reynolds, Sandip K. Basu et al. Cell
  42. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase (1978)
    Michael S. Brown, J R Faust et al. Journal of Biological Chemistry
  43. Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts (1974)
    Michael S. Brown, Suzanna E. Dana et al. Journal of Biological Chemistry
  44. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. (1979)
    Michael S. Brown, J L Goldstein et al. The Journal of Cell Biology
  45. Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity (1974)
    Michael S. Brown, Joseph L. Goldstein Proceedings of the National Academy of Sciences
  46. Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol (1974)
    Michael S. Brown, Joseph L. Goldstein Journal of Biological Chemistry
  47. The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages (1980)
    Michael S. Brown, Sandip K. Basu et al. Journal of Supramolecular Structure
  48. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts (1975)
    Michael S. Brown, Joseph L. Goldstein Cell
  49. Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts (1983)
    Janet M. Larkin, Michael S. Brown et al. Cell
  50. Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains (1985)
    Mark A. Lehrman, Wolfgang J. Schneider et al. Science
  51. How LDL Receptors Influence Cholesterol and Atherosclerosis (1984)
    Michael S. Brown, Joseph L. Goldstein Scientific American
  52. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. (1981)
    Petri T. Kovanen, D W Bilheimer et al. Proceedings of the National Academy of Sciences
  53. Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia (1984)
    David W. Bilheimer, Joseph L. Goldstein et al. New England Journal of Medicine
  54. Retrospective on Cholesterol Homeostasis: The Central Role of Scap (2017)
    Michael S. Brown, Arun Radhakrishnan et al. Annual Review of Biochemistry
  55. Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme (1985)
    Gregorio Gil, Jerry R. Faust et al. Cell
  56. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes (1982)
    Vassilis I. Zannis, Jan L. Breslow et al. Journal of Lipid Research
  57. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region (1987)
    Claire Davis, Joseph L. Goldstein et al. Nature
  58. Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor (1984)
    David W. Russell, Wolfgang J. Schneider et al. Cell
  59. Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight. (1982)
    Wolfgang J. Schneider, Ulrike Beisiegel† et al. Journal of Biological Chemistry
  60. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol (1984)
    Joseph L. Goldstein, Michael S. Brown Journal of Lipid Research
  61. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. (1980)
    J L Goldstein, Y K Ho et al. Journal of Biological Chemistry
  62. Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholesterol (1973)
    Joseph L. Goldstein, Michael S. Brown Proceedings of the National Academy of Sciences
  63. Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase (1980)
    Toru Kita, Michael S. Brown et al. Journal of Clinical Investigation
  64. Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins (1973)
    Michael S. Brown, Suzanna E. Dana et al. Proceedings of the National Academy of Sciences
  65. Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states. (1979)
    Michael S. Brown, J L Goldstein et al. Journal of Biological Chemistry
  66. Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. (1975)
    Michael S. Brown, J R Faust et al. Journal of Clinical Investigation
  67. Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. (1985)
    Laura Liscum, Janet Finer-Moore et al. Journal of Biological Chemistry
  68. Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. (1976)
    R G Anderson, Joseph L. Goldstein et al. Proceedings of the National Academy of Sciences
  69. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. (1981)
    Wolfgang J. Schneider, Petri T. Kovanen et al. Journal of Clinical Investigation
  70. Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex (1979)
    Michael S. Brown, Petri T. Kovanen et al. PubMed
  71. Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain (1985)
    Mark A. Lehrman, Joseph L. Goldstein et al. Cell
  72. Visualization of lipoprotein receptors by ligand blotting. (1983)
    Thomas O. Daniel, Wolfgang J. Schneider et al. Journal of Biological Chemistry
  73. Atherosclerosis: The low-density lipoprotein receptor hypothesis (1977)
    Joseph L. Goldstein, Michael S. Brown Metabolism
  74. Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia (1974)
    Joseph L. Goldstein, Suzanna E. Dana et al. Proceedings of the National Academy of Sciences
  75. Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species (1980)
    Robert W. Mahley, T L Innerarity et al. Journal of Lipid Research
  76. Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia. (1983)
    L. Maximilian Buja, Tomoko Kita et al. Arteriosclerosis An Official Journal of the American Heart Association Inc
  77. A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts (1977)
    Richard G.W. Anderson, Joseph L. Goldstein et al. Nature
  78. The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor (1983)
    Helge Tolleshaug, Michael S. Brown et al. Cell
  79. Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia (1982)
    Helge Tolleshaug, Joseph L. Goldstein et al. Cell
  80. 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (1973)
    Michael S. Brown, Suzanna E. Dana et al. Journal of Biological Chemistry
  81. Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia. (1981)
    Toshiyuki Kita, Michael S. Brown et al. Proceedings of the National Academy of Sciences

Immediate Impact

36 by Nobel laureates 65 from Science/Nature 129 standout
Sub-graph 1 of 22

Citing Papers

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10 intermediate papers

Works of Michael S. Brown being referenced

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 StandoutNobel
Selective versus Total Insulin Resistance: A Pathogenic Paradox
2008 StandoutNobel
and 6 more

Author Peers

Author Last Decade Papers Cites
Michael S. Brown 47368 39054 14828 365 91.3k
Joseph L. Goldstein 51330 41912 15746 399 98.5k
Ronald M. Evans 95165 13175 11983 619 146.4k
Bart Staels 40867 16704 7996 781 77.2k
Johan Auwerx 50378 12505 8040 632 94.3k
David J. Mangelsdorf 39650 21964 5747 221 69.2k
C. Ronald Kahn 36433 14266 5579 511 73.3k
Gerald I. Shulman 48857 19421 5057 614 104.2k
Christopher K. Glass 60633 8643 12036 372 94.9k
Lewis C. Cantley 103801 10703 29279 702 148.2k
Jerrold M. Olefsky 34169 12227 4518 588 70.4k

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