Standout Papers

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Respons... 1997 2026 2006 2016 7.4k
  1. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy (2004)
    J. Guillermo Paez, Pasi A. Jänne et al. Science
  2. EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib (2005)
    Susumu Kobayashi, Titus J. Boggon et al. New England Journal of Medicine
  3. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP (2008)
    Cai‐Hong Yun, Kristen E. Mengwasser et al. Proceedings of the National Academy of Sciences
  4. Three-dimensional structure of the tyrosine kinase c-Src (1997)
    Wenqing Xu, Stephen C. Harrison et al. Nature
  5. Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity (2007)
    Cai‐Hong Yun, Titus J. Boggon et al. Cancer Cell
  6. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling (1995)
    Zhou Songyang, Kermit L. Carraway et al. Nature
  7. Crystal Structure of the Tyrosine Phosphatase SHP-2 (1998)
    Peter Hof, Scott Pluskey et al. Cell
  8. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M (2009)
    Wenjun Zhou, Dalia Ercan et al. Nature
  9. Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism (1999)
    Wenqing Xu, Amish Doshi et al. Molecular Cell
  10. Mechanism and Function of Formins in the Control of Actin Assembly (2007)
    Bruce L. Goode, Michael J. Eck Annual Review of Biochemistry
  11. Structure and regulation of Src family kinases (2004)
    Titus J. Boggon, Michael J. Eck Oncogene

Immediate Impact

9 by Nobel laureates 46 from Science/Nature 135 standout
Sub-graph 1 of 18

Citing Papers

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2024 StandoutNature
Pan-cancer whole-genome comparison of primary and metastatic solid tumours
2023 StandoutNature
7 intermediate papers

Works of Michael J. Eck being referenced

Cetuximab Response of Lung Cancer–Derived EGF Receptor Mutants Is Associated with Asymmetric Dimerization
2013
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
2008 Standout
and 7 more

Author Peers

Author Last Decade Papers Cites
Michael J. Eck 18019 12335 11015 156 32.0k
Jeffrey A. Engelman 20979 15823 13540 181 35.4k
Neal Rosen 24403 12021 5578 255 34.3k
Patricia S. Steeg 13074 8285 5165 198 22.7k
Jeffrey Settleman 13871 10236 7598 158 23.2k
Kwok‐Kin Wong 17392 10794 7779 271 28.3k
Carlos L. Arteaga 19578 18114 7120 429 34.0k
Robert S. Kerbel 24243 16351 5745 398 41.1k
Julian Downward 29860 11325 3076 289 41.2k
Nathanael S. Gray 29806 10733 4803 471 41.2k
David A. Tuveson 19285 20810 4694 200 40.1k

All Works

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