Standout Papers
Citation Impact
Citing Papers
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
2010 Science
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival
2011
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
2007
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
2014
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
2012
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
2017
MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib
2009
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
Genetic determinants of hepatic steatosis in man
2011
Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
2013
Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats
2001
Functional diversity of helper T lymphocytes
1996 StandoutNature
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
2013 Standout
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase
2016
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
2018
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
2012
Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
2006
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
2009
Systematic Identification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance
2008
Improved antisense oligonucleotide induced exon skipping in the mdx mouse model of muscular dystrophy
2002
LNA-mediated microRNA silencing in non-human primates
2008 Nature
Exacerbated autoimmunity associated with a T helper‐1 cytokine profile shift in H‐2E‐transgenic mice
1995
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
2012
Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
2017
CD4+ T-cell subsets in autoimmunity
1997
Regulatory T Cells
2000 StandoutNobel
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure
2013 StandoutNobel
Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics
2010 StandoutNobel
Integration of microRNA miR-122 in hepatic circadian gene expression
2009
Regulation of hepatic glucose metabolism in health and disease
2017
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
2017
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
2015
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
2014 Nature
Long Noncoding RNAs in Cancer Pathways
2016 Standout
Dissociating fatty liver and diabetes
2012
MicroRNA-122 Modulates the Rhythmic Expression Profile of the Circadian Deadenylase Nocturnin in Mouse Liver
2010
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
2007 Nature
T cell responses to myelin basic protein in experimental autoimmune encephalomyelitis-resistant BALB/c mice
1993
Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis
2016 Standout
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
2010
miR-122 is a Unique Molecule with Great Potential in Diagnosis, Prognosis of Liver Disease, and Therapy Both as miRNA Mimic and Antimir
2015
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
2013
Therapeutic targeting of microRNAs: current status and future challenges
2014
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
2015
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
2021 StandoutNobel
Paving the Road for RNA Therapeutics
2020
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma #
2008
Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
2011
Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance
2007
Targeted Exon Skipping in Transgenic hDMD Mice: A Model for Direct Preclinical Screening of Human-Specific Antisense Oligonucleotides
2004
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
Unraveling the Regulation of Hepatic Metabolism by Insulin
2017
Biochemical and cellular properties of insulin receptor signalling
2017
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
2007 Standout
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
2012
Fructose induced lipogenesis: from sugar to fat to insulin resistance
2010
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
2016
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies
2011
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
2009
miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression
2012
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
1999 StandoutNature
Evidence that microRNAs are associated with translating messenger RNAs in human cells
2006
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer
2017 StandoutNobel
Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger
1999
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy
2011
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Revealing the world of RNA interference
2004 StandoutNatureNobel
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
2007
Lipid-induced insulin resistance: unravelling the mechanism
2010
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
2011
MicroRNA‐29, a key regulator of collagen expression in systemic sclerosis
2010
The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases
2000
MicroRNAs: A new class of regulatory genes affecting metabolism
2006
Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome
2008
Endogenous microRNA sponges: evidence and controversy
2016 Standout
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
2012
Knocking down barriers: advances in siRNA delivery
2009 Standout
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
2011
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
Micro-Managing the Circadian Clock: The Role of microRNAs in Biological Timekeeping
2012
Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance
2014
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
2015
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
2008 Standout
Treatment of HCV Infection by Targeting MicroRNA
2013 Standout
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
2015
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
2012
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
2014
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Development of micro RNA therapeutics is coming of age
2014
microRNA‐122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
2010
In Vitro Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122
2014
The Nine Lives of ACAT Inhibitors
2006
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
2012
Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122
2010
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
2013
Modulation of Hepatitis C Virus RNA Abundance and the Isoprenoid Biosynthesis Pathway by MicroRNA miR-122 Involves Distinct Mechanisms
2009
Nuclear receptor PPARγ-regulated monoacylglycerol O -acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
2012
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Progress in the Delivery of Therapeutic Oligonucleotides: Organ/Cellular Distribution and Targeted Delivery of OligonucleotidesIn Vivo
2003
Pyripyropene A, an Acyl–Coenzyme A:Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia
2011 StandoutNobel
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids
2015
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
2011
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
1996
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice
2002 StandoutNobel
IL-12 unmasks latent autoimmune disease in resistant mice.
1996
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression
2016 StandoutNobel
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice
2018
MicroRNA‐122 regulates polyploidization in the murine liver
2016
Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.
1993
Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver
2017
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk
2017
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
2018
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Late Complications of Immune Deviation Therapy in a Nonhuman Primate
1996 Science
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis
1997
microRNAs in Vertebrate Physiology and Human Disease
2007
Nascent-Seq analysis of Drosophila cycling gene expression
2013 StandoutNobel
microRNA Functions
2007 Standout
Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles
2004 StandoutNobel
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?
2015
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
T-cell subsets in autoimmunity
1993
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
2016
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
2016
Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice
2015
Works of Mark J. Graham being referenced
Phosphorothioate Oligodeoxynucleotides Distribute Similarly in Class A Scavenger Receptor Knockout and Wild-Type Mice
2000
Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration212Abbreviations: HSV, herpes simplex virus; CGE, capillary gel electrophoresis; and HPLC/ES-MS, high performance liquid chromatography/electrospray-mass spectrometry.1Johnston J, ISIS Pharmaceuticals, personal communication. Cited with permission.
2001
Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
2013
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
2010
Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression
2012
Tritium labeling of antisense oligonucleotides by exchange with tritiated water
1993
Aberrant Hepatic Expression of PPARγ2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis
2006
Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
2008
Effect of Antisense Oligonucleotides on Cytokine Release from Human Keratinocytes in anin VitroModel of Skin
1996
An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
2005
Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities but Not Inflammation and Injury in Mice
2014
Pharmacokinetic and Toxicity Profile of a Phosphorothioate Oligonucleotide Following Inhalation Delivery to Lung in Mice
2000
Modulation of Lipoprotein Metabolism by Antisense Technology: Preclinical Drug Discovery Methodology
2013
Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA
2016
Inhibition of ADRP prevents diet-induced insulin resistance
2008
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
2012
Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
1990
Quantitation of Phosphorothioate Oligonucleotides in Human Plasma
1996
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
2006 Standout
Reduction of Hepatosteatosis and Lipid Levels by an Adipose Differentiation-Related Protein Antisense Oligonucleotide
2007
Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism*
2010
Targeting APOC3 in the Familial Chylomicronemia Syndrome
2014
Liver-Specific Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 With Antisense Oligonucleotides Limits Atherosclerosis Development in Apolipoprotein B100–Only Low-Density Lipoprotein Receptor −/− Mice
2006
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
2016
Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers
2014
CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
2012
Potent Reduction of Apolipoprotein B and Low-Density Lipoprotein Cholesterol by Short-Term Administration of an Antisense Inhibitor of Apolipoprotein B
2006
No Time to Think: Making Room for Reflection in Obstetrics and Gynecology Residency
2010
Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice
2008
Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets
2010
Modification of MyD88 mRNA Splicing and Inhibition of IL-1β Signaling in Cell Culture and in Mice with a 2′-O-Methoxyethyl-Modified Oligonucleotide
2006
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice
2014
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
2018
Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice
2012
Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice
2014
In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides.
1995
Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression
2012