Standout Papers
- The tumor microenvironment (2020)
- Hypoxia-Inducible Factors and the Response to Hypoxic Stress (2010)
- Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase (2005)
- Mitochondrial reactive oxygen species trigger hypoxia-induced transcription (1998)
- Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature (2019)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
2008
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
2008 Standout
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
2009
Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment
2009
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
2009
IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
2007
A transcription factor response element for gene expression during circadian night
2002 Nature
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells
2005
Genetic evidence for a tumor suppressor role of HIF-2α
2005
MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1
2011 StandoutNobel
Mitochondrial reactive oxygen species regulate hypoxic signaling
2009
Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
2010
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
2012 Nature
Regulation of Angiogenesis by Oxygen and Metabolism
2009
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
2011 StandoutNobel
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
2011 Nature
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
2015
Two transactivation mechanisms cooperate for the bulk of HIF‐1‐responsive gene expression
2005
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
2004
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Treatment of kidney cancer
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms
2007 StandoutNobel
HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies
2006
Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2
2002
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis
2009 Science
Expression ofPeriodGenes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker
2001
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia
2007
The role of hypoxia-inducible factors in tumorigenesis
2008
Hypoxia and the HIF system in kidney disease
2007
Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation
2011 StandoutNobel
Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2
2006
TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
2014
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
Hypoxia-regulated target genes implicated in tumor metastasis
2012
The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
2007 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice
2011
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
2007
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
2006 StandoutNobel
HIF-1α induces MXI1 by alternate promoter usage in human neuroblastoma cells
2009
Human HIF‐3α4 is a dominant‐negative regulator of HIF‐1 and is down‐regulated in renal cell carcinoma
2005
Role of monocarboxylate transporters in human cancers: state of the art
2012
HIF‐1α and HIF‐2α have divergent roles in colon cancer
2008
Adaptive Myogenesis under Hypoxia
2005
Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression
2013
A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis
2008
Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression
2010
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
2015
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
1996 StandoutNature
Proteins regulating Ras and its relatives
1993 StandoutNature
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
2001
The helix-loop-helix gene E2A is required for B cell formation
1994
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
1993
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
2009 Standout
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains
1994 Nature
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1
2007 StandoutNobel
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia
2016
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
2006 Standout
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
2008 StandoutNobel
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
2010
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
1993 Nature
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
2008
Metabolic Regulation of Epigenetics
2012
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
2007 StandoutNobel
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
2010
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
2015
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
2000 Standout
Emerging interactions between skin stem cells and their niches
2014
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
2016 Nature
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Regulation of DNA repair in hypoxic cancer cells
2007
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene
2001
Effects of hypoxia on tumor metabolism
2007
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
2009
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway
2007
Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
2006 StandoutNobel
Oxygen sensing and signaling: impact on the regulation of physiologically important genes
1999
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
2008 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
2007
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
1993 Nature
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes
2011
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Hypoxia and Inflammation
2011 Standout
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
2008
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
SH2 and SH3 domains
1993
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
2018
Origins of Metastatic Traits
2013
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
2010
Akt-dependent transformation: there is more to growth than just surviving
2005
Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
2006
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?
2010
Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice
2011
Sirtuins, Aging, and Metabolism
2011
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
2016
Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1
2005
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
Time zones: a comparative genetics of circadian clocks
2001
Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration
2006
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
2010
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
2008
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
Transcriptional regulation by hypoxia inducible factors
2013
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation
1998
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
2011
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
2017
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
2005
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
2010
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide
1999
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
2004
Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly
1988
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
2003
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
2013
Hypoxia‐inducible factor as a physiological regulator
2005
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
2017
Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice
2001
Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation
1998
Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1
2002
Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
2015
Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
2003 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
2013
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene
2000 StandoutNobel
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions
2012
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Hypoxia signalling in cancer and approaches to enforce tumour regression
2006 Nature
The Role of Hypoxia in Development of the Mammalian Embryo
2009
Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock
2001
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors
2004
Genome-wide analysis revealsNRP1as a direct HIF1α-E2F7 target in the regulation of motorneuron guidancein vivo
2015
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Protein modules and signalling networks
1995 StandoutNature
Microarray analyses of hypoxia‐regulated genes in an aryl hydrocarbon receptor nuclear translocator (Arnt)‐dependent manner
2008
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
2002 Nature
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer
2015 StandoutNobel
Development of HIF‐1 inhibitors for cancer therapy
2009
MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU
2010
Structural basis for the binding of proline-rich peptides to SH3 domains
1994
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
2010
MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300
2003
Hypoxia response and microRNAs: no longer two separate worlds
2008
PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia
2010
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Hypoxia and cancer
2007
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
2005
HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
2008
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
2011
Hypoxia-driven selection of the metastatic phenotype
2007
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
2016 Nature
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
2002
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
2006
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
1993 Nature
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β
2012
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
2009
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
2014
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
1993 Nature
Orientation of Peptide Fragments from Sos Proteins Bound to the N-Terminal SH3 Domain of Grb2 Determined by NMR Spectroscopy
1994
Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1
2010
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Hypoxia, gene expression, and metastasis
2007
Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
2015
ATP citrate lyase inhibition can suppress tumor cell growth
2005
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
2007
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
2001 StandoutNature
Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
2007
miR‐210: More than a silent player in hypoxia
2011
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Perspectives on Oxygen Sensing
1999 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells
2002
Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma
2013
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
2007
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
2017 Nature
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Pyruvate kinase M2 is a phosphotyrosine-binding protein
2008 Nature
Hypoxia Induces Production of L-2-Hydroxyglutarate
2015
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
2010
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Coordination of circadian timing in mammals
2002 StandoutNature
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
2011
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
2010
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
2001
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1
2002
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
2000 StandoutNobel
Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data
2012
SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
2013
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer
2012
Evaluation of HIF-1 inhibitors as anticancer agents
2007 StandoutNobel
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators
2001
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
2013
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
1993
Mechanisms and Implications of Metabolic Heterogeneity in Cancer
2019
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
2012 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
2008
Hypoxia Post-translationally Activates Iron-regulatory Protein 2
1999
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
2010
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation
2016
HIF and the Lung
2011 StandoutNobel
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
2011 StandoutNobel
Therapeutic Manipulation of the HIF Hydroxylases
2009
Regulation of early adenovirus gene expression
1987
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1999
Tumor Metabolism of Lactate: The Influence and Therapeutic Potential for MCT and CD147 Regulation
2009
Mutation analysis of the Pip interaction domain reveals critical residues for protein–protein interactions
1999
Life with Oxygen
2007 StandoutScienceNobel
Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans
2000
Hypoxia suppresses conversion from proliferative arrest to cellular senescence
2012
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
2007 StandoutNobel
Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes
1999
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
Murine Macrophage Mannose Receptor Promoter Is Regulated by the Transcription Factors PU.1 and SP1
1997
Integration of Oxygen Signaling at the Consensus HRE
2005
Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences.
1994
Fundamentals of cancer metabolism
2016 Standout
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.
1994
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
1994
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.
1994 Nobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Essential role of B-Raf in ERK activation during extraembryonic development
2006
Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.
1993
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Akt Stimulates Aerobic Glycolysis in Cancer Cells
2004
c-Abl kinase regulates the protein binding activity of c-Crk.
1994
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
Hypoxia-induced methylation of a pontin chromatin remodeling factor
2011
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
2007
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
2011 StandoutNobel
Signal transduction by reactive oxygen species
2011 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Epigenetics: New Questions on the Response to Hypoxia
2011
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.
1993
Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes
2010
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
2012
Regulation of TFEB and V-ATPases by mTORC1
2011
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
2004 StandoutNobel
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
1994
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
1994
Hypoxia. 5. Hypoxia and hematopoiesis
2011
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
2007
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
2004 StandoutNobel
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.
1994
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Hypoxia as a therapy for mitochondrial disease
2016 Science
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
1994
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
1993
PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes
1997
Metabolic reprogramming and cancer progression
2020 StandoutScience
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
2004
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
2007 StandoutNobel
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
2009
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation
2008
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.
1994
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
1995
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
2004
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
1998
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
1994
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
2000 Standout
Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A
2012
A MicroRNA Signature of Hypoxia
2006
Vitamin C is dispensable for oxygen sensing in vivo
2011
Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.
1993
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways
1993 Science
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
1998
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma
2000 StandoutScience
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.
1994
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
2012
Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes
1993 Science
Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression
1997
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
2015
Works of M. Celeste Simon being referenced
Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1α
2010
Heterozygosity for Hypoxia Inducible Factor 1α Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model
2009
Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis
2013
Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth
2005
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors
2006
The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
2010
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
2009
Hypoxia-Inducible Factors, Stem Cells, and Cancer
2007
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Acute postnatal ablation of Hif-2 α results in anemia
2007
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
2008
von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2α signaling and splenic erythropoiesis
2007
HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
2006
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
2010
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina
2010
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
2014 Nature
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
2000
Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism
2008
Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation
2005
The impact of O2 availability on human cancer
2008
HIF-2α, but not HIF-1α, promotes iron absorption in mice
2009
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Hypoxia inducible factor-2α: a critical mediator of aggressive tumor phenotypes
2009
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Mxi1 is induced by hypoxia in a HIF-1–dependent manner and protects cells from c-Myc-induced apoptosis
2005
Biology of hypoxia-inducible factor-2α in development and disease
2008
HIF-Dependent Hematopoietic Factors Regulate the Development of the Embryonic Vasculature
2006
The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
2007
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
1996
Hypoxia, HIFs, and Cardiovascular Development
2002
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation
1988
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
2013
Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development
1998
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
2004
Regulation of Transcription and Translation by Hypoxia
2004
HIFs, Hypoxia, and Vascular Development
2004
Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?
2012
Metastasis and stem cell pathways
2007
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro
1993
The role of oxygen availability in embryonic development and stem cell function
2008
Reactive oxygen species and cellular oxygen sensing
2007
Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization
2007
Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells
1992
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
2005 Standout
PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR
2006 Nature
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
2005
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
2005
Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response
2008
A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets
2003
Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
1999
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
2007
Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1α nor Sufficient for HIF-1-dependent Target Gene Transcription
2002
Expansion of human SCID-repopulating cells under hypoxic conditions
2003
Hypoxia-inducible factors: central regulators of the tumor phenotype
2007
cGMP-dependent Protein Kinase Phosphorylates p21-activated Kinase (Pak) 1, Inhibiting Pak/Nck Binding and Stimulating Pak/Vasodilator-stimulated Phosphoprotein Association
2006
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
2007
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
2004
Hypoxia-Induced Angiogenesis: Good and Evil
2011
O2 regulates stem cells through Wnt/β-catenin signalling
2010
Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo
2007
Hypoxia-inducible factors, hypoxia, and tumor angiogenesis
2006
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth
2006
PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
1995
Effects of hypoxia and HIFs on cancer metabolism
2012
pVHL Function Is Essential for Endothelial Extracellular Matrix Deposition
2006
Selective Induction of Human Heat Shock Gene Transcription by the Adenovirus E1A Gene Products, Including the 12S E1A Product
1987
Hypoxia affects mesoderm and enhances hemangioblast specification during early development
2004
Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages
1994 Science
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
2000
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Hypoxia-inducible Factor Regulates αvβ3 Integrin Cell Surface Expression
2005
Decreased Growth of Vhl − / − Fibrosarcomas Is Associated with Elevated Levels of Cyclin Kinase Inhibitors p21 and p27
2005
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
2009
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta
2005
HIF-2α deletion promotes Kras-driven lung tumor development
2010
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
2011
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
1992
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
1998 Standout
The Myeloid-Cell-Specific c-fesPromoter Is Regulated by Sp1, PU.1, and a Novel Transcription Factor
1996
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
2006