Citation Impact
Citing Papers
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
TOR Signaling in Growth and Metabolism
2006 Standout
PKB/AKT: functional insights from genetic models
2001
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion
2004
Regulation of Angiogenesis by Oxygen and Metabolism
2009
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Linoleic acid-induced endothelial activation
2004
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage
2003
Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium
2009
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter
2004 StandoutNobel
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
mTOR Signaling in Growth Control and Disease
2012 Standout
Nitric oxide synthases: regulation and function
2011 Standout
Necroptosis and its role in inflammation
2015 StandoutNature
Impaired Nitric Oxide-Mediated Flow-Induced Coronary Dilation in Hyperhomocysteinemia
2002
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
2008
Cell signaling by reactive nitrogen and oxygen species in atherosclerosis
2000
Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors
2009
Genetics, epigenetics and pharmaco‐(epi)genomics in angiogenesis
2008
The clinical significance of endothelial dysfunction
2005
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
2010
Regulation of p21WAF1/CIP1 Stability by WISp39, a Hsp90 Binding TPR Protein
2005
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
2003
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1
2011
Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia–reperfusion injury in rats
2006
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival
2002
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
2007
Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction
2008
p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export
2002
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein
2002
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
2003
Myocardial Contractile Effects of Nitric Oxide
2002
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
2008
Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines
2003
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
Hypoxia Potentiates Nitric Oxide-mediated Apoptosis in Endothelial Cells via Peroxynitrite-induced Activation of Mitochondria-dependent and -independent Pathways
2004
Valproic Acid Inhibits Angiogenesis in Vitro and in Vivo
2004
Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
2009
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
2004
p21 in cancer: intricate networks and multiple activities
2009 Standout
14‐3‐3 suppresses the nuclear localization of threonine 157‐phosphorylated p27Kip1
2004
Role of Oxidative and Nitrosative Stress, Longevity Genes and Poly(ADPribose) Polymerase in Cardiovascular Dysfunction Associated with Aging
2005
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
2003
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
Recent progress in the biology and physiology of sirtuins
2009 Nature
Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cδ-mediated phosphorylation
2007
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial
2003
Hypoxia: A key regulator of angiogenesis in cancer
2007
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
2008
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
PI3K/Akt: getting it right matters
2008
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
The Hallmarks of Aging
2013 Standout
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
2002
The role of nitric oxide in tumour progression
2006
Dose–response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686288)
2007 Nobel
Reactive oxygen species, cellular redox systems, and apoptosis
2010 Standout
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Structure, regulation and function of PKB/AKT—a major therapeutic target
2003
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 Standout
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition
2003
Endothelial Progenitor Cells and Vascular Biology in Diabetes Mellitus: Current Knowledge and Future Perspectives
2005
A Molecular and Cellular Theory of Depression
1997 Standout
Latest Advances in Understanding Preeclampsia
2005 StandoutScience
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
1996 Standout
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Oxidative Stress and Preeclampsia
2004
Receptors for Purines and Pyrimidines
1998 Standout
Young Adult Bone Marrow–Derived Endothelial Precursor Cells Restore Aging-Impaired Cardiac Angiogenic Function
2002
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice
2017
Oxidative Stress–Mediated Cardiac Cell Death Is a Major Determinant of Ventricular Dysfunction and Failure in Dog Dilated Cardiomyopathy
2001
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
2002
Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding
2006
Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589
2006
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase
2004
Glycogen Synthase Kinase-3 Mediates Endothelial Cell Activation by Tumor Necrosis Factor-α
2005
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1
2007
Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries
2003
Prevention and Reversal of Premature Endothelial Cell Senescence and Vasculopathy in Obesity-Induced Diabetes by Ebselen
2003
Role of Heat Shock Proteins in Atherosclerosis
2002
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21Cip1 on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21Cip1-Imposed G1 Arrest
2006
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
2003
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
2004
Endothelial Progenitor Cells
2004 Standout
Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
2004
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
2004
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
2003 StandoutScience
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Lothar Rössig being referenced
Glycogen Synthase Kinase-3 Couples AKT-dependent Signaling to the Regulation of p21Cip1 Degradation
2002
SIRT1 controls endothelial angiogenic functions during vascular growth
2007
Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apotosis
2002
Impairment of ATP-induced Ca2+-signalling in human thyroid cancer cells
1997
Extracellular ATP and UTP Increase Cytosolic Free Calcium by Activating a Common P2U-Receptor in Single Human Thyrocytes
1995
Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for ‘pleiotropic’ functions of statin therapy
2006
Apoptosis in the vascular wall and atherosclerosis
2001
Nitric Oxide Inhibits Caspase-3 by S-Nitrosationin Vivo
1999
Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol
2000
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription.
1995
Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli
2001
p38 Mitogen-Activated Protein Kinase Downregulates Endothelial Progenitor Cells
2005
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy
2006
Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions
2009
Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells
2001
Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events
2005
Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and Angiogenesis
2002
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
2005
Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure
2001
HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes
2003
p21 Cip1 Levels Differentially Regulate Turnover of Mature Endothelial Cells, Endothelial Progenitor Cells, and In Vivo Neovascularization
2004