Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
2010 StandoutScience
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
2008
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
2009
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
2015 StandoutScience
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
2011 StandoutScience
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
2008 StandoutScience
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
The Role of Innate and Adaptive Immunity in Parkinson's Disease
2013
A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function
2011
The DNA-damage response in human biology and disease
2009 StandoutNature
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
2014
Inflammatory processes in amyotrophic lateral sclerosis
2002
Ion Homeostasis in Rat Brain in vivo: Intra- and Extracellular [Ca2+] and [H+] in the Hippocampus during Recovery from Short-Term, Transient Ischemia
1992
Changes in cerebral energy metabolism and calcium levels in relation to delayed neuronal death after ischemia
1992
Pericytes are required for blood–brain barrier integrity during embryogenesis
2010 StandoutNature
Increased intracellular Ca2+ concentration in the hippocampal CA1 area during global ischemia and reperfusion in the rat: a possible cause of delayed neuronal death
1999
Disease-Specific Induced Pluripotent Stem Cells
2008 Standout
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
2013
Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death
1999
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
2008
ALS: Focus on purinergic signalling
2011
Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
2013
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
The role of early Ca2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils
1993
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis
2013
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
2007
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
2014
Microglia in the developing brain: from immunity to behaviour
2010
Origin of Microglia: Current Concepts and Past Controversies
2015
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
Microglia and neuroprotection: From in vitro studies to therapeutic applications
2010
Origin and differentiation of microglia
2013
Microglial cell origin and phenotypes in health and disease
2011 Standout
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
2013
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
2014
Regional and Temporal Alterations in Ca2+/Calmodulin‐Dependent Protein Kinase II and Calcineurin in the Hippocampus of Rat Brain After Transient Forebrain Ischemia
1992
The Role of Immune and Inflammatory Mechanisms in ALS
2011
Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model
2007
Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits
2011
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
2007 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
Chapter 11 Disturbances of cerebral protein synthesis and ischemic cell death
1993
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
2007
Factors regulating microglia activation
2013
Contribution of systemic inflammation to chronic neurodegeneration
2010
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
2012
Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1
2008
Energetics in the pathogenesis of neurodegenerative diseases
2000
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
2008
Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS
2007
Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease?
2008
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
2013 Standout
Misregulated RNA processing in amyotrophic lateral sclerosis
2012
Immunological features of α‐synuclein in Parkinson's disease
2008
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain
1993
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria
2004
Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion
1998
Microglia in ALS: The Good, The Bad, and The Resting
2009
Calcium-related damage in ischemia
1996
Alzheimer's Disease
2010 Standout
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Innate immunity: the missing link in neuroprotection and neurodegeneration?
2002
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
2013 Standout
A Fresh Look at iPS Cells
2009 StandoutNobel
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Neuroglial activation and neuroinflammation in the brain of patients with autism
2004 Standout
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
1995 StandoutNobel
Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
2009
MK-801, a glutamate antagonist, lowers flow threshold for inhibition of protein synthesis after middle cerebral artery occlusion of rat
1993
Amyotrophic lateral sclerosis: A neurovascular disease
2011
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
DNA repair, mitochondria, and neurodegeneration
2006
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
2011
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
2014 Standout
Delayed decreases in specific brain mitochondrial electron transfer complex activities and cytochrome concentrations following anoxia/ischemia
1990
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
2015
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
2011
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Amyotrophic Lateral Sclerosis
2001 Standout
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
2015
Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2
2008
Increased persistent Na+ current and its effect on excitability in motoneurones cultured from mutant SOD1 mice
2005
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
2009
Protective Effect of Hypothermia on Hippocampal Injury After 30 Minutes of Forebrain Ischemia in Rats Is Mediated by Postischemic Recovery of Protein Synthesis
1993
Ultrastructural analysis of spinal motoneurones from mice treated with IgG from ALS patients, healthy individuals, or disease controls
2000
Microglial Physiology: Unique Stimuli, Specialized Responses
2009
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis
2007
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Mitochondria: The Missing Link Between Preconditioning and Neuroprotection
2010
Neuroimmunological Processes in Parkinson’s Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity
2013
Multiple Sclerosis
2018 Standout
Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies
2008
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Calcium in Ischemic Cell Death
1998
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
2008
Changing Face of Microglia
2010 Science
Targeting miR ‐155 restores abnormal microglia and attenuates disease in SOD 1 mice
2014
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells
2012
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
2017
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
1987 StandoutNobel
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
2016
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
2008
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
2011
Ischemic Cell Death in Brain Neurons
1999 Standout
Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease
2008
Enhanced Calcium Uptake by CA1 Pyramidal Cell Dendrites in the Postischemic Phase despite Subnormal Evoked Field Potentials: Excitatory Amino Acid Receptor Dependency and Relationship to Neuronal Damage
1992
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Microbiome–microglia connections via the gut–brain axis
2018
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
1990 Standout
DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS
2009
Excitotoxicity and Amyotrophic Lateral Sclerosis
2005
Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
2008
Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.
1987 StandoutNobel
The Calmodulin Antagonist Trifluoperazine in Transient Focal Brain Ischemia in Rats
1997
AMPA Exposures Induce Mitochondrial Ca2+Overload and ROS Generation in Spinal Motor NeuronsIn Vitro
2000
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
2011 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Estrogens, Neuroinflammation, and Neurodegeneration
2016
Ultrastructural Localization of Calcium in Ischemic Hippocampal Slices: The Influence of Adenosine and Theophylline
1992
Calcium Movement in Ischemia-Tolerant Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Gerbils
1996
The microglial-motoneuron dialogue in ALS.
2011
Works of László Siklós being referenced
An MND/ALS phenotype associated with C9orf72 repeat expansion: Abundant p62‐positive, TDP‐43‐negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline
2011
The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
2005
Parvalbumin overexpression alters immune‐mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis
2001
Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin‐mediated calcium increase, and neurotransmitter release in motor neurons
2002
Altered Calcium Homeostasis and Ultrastructure in Motoneurons of Mice Caused by Passively Transferred Anti-motoneuronal IgG
1997
PARP Expression Is Increased in Astrocytes but Decreased in Motor Neurons in the Spinal Cord of Sporadic ALS Patients
2003
Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophc lateral sclerosis
1996
Experimental Destruction of Substantia Nigra Initiated by Parkinson Disease Immunoglobulins
1998
Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons
1995
Axotomy induces contrasting changes in calcium and calcium-binding proteins in oculomotor and hypoglossal nuclei of Balb/c mice
2006
Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
2003
Diazoxide prevents mitochondrial swelling and Ca 2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs
2004
Calcium in the mitochondria following brief ischemia of gerbil brain
1987
Calcium: the Darth Vader of ALS
2001
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
2006