Citation Impact
Citing Papers
Guidelines for the welfare and use of animals in cancer research
2010 Standout
Hyaluronic Acid Hydrogels for Biomedical Applications
2011 Standout
A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series
2010
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
Drugs as CYP3A Probes, Inducers, and Inhibitors
2007
Polymorphism of human cytochrome P450 enzymes and its clinical impact
2009
Network pharmacology: the next paradigm in drug discovery
2008 Standout
Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor
2013
Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values
2009
Metabolic Drug Interactions with Newer Antipsychotics: A Comparative Review
2006
Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor
2008
Microfluidic organs-on-chips
2014 Standout
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
From carbohydrate leads to glycomimetic drugs
2009
Discovery of small molecule human C5a receptor antagonists
2009
Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine
2013 StandoutNobel
The use of spirocyclic scaffolds in drug discovery
2014 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
The role of drug metabolizing enzymes in clearance
2014
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
2017 Standout
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human
2012
A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening
2011
Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds
2009
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
Rings in Drugs
2014 Standout
Fluorine in medicinal chemistry
2007 Standout
Sequential one-pot glycosylation with glycosyl N-trichloroacetylcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars
2011 StandoutNobel
Nuclear Magnetic Resonance Metabolomic Footprinting of Human Hepatic Stem Cells and Hepatoblasts Cultured in Hyaluronan-Matrix Hydrogels
2008
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
2018
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Oxadiazoles in Medicinal Chemistry
2011 Standout
Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review
2018 Standout
Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study
2018 StandoutNobel
The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery
2007
Oxadiazole isomers: all bioisosteres are not created equal
2012
Preclinical experimental models of drug metabolism and disposition in drug discovery and development
2012
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology
2012 Standout
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
2013
Prescribed drugs containing nitrogen heterocycles: an overview
2020 Standout
Works of Ken Grime being referenced
EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES
2006
Metabolic screening in vitro: metabolic stability, CYP inhibition and induction
2004
Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
2007
Optimisation of DMPK by the Inhaled Route: Challenges and Approaches
2012
The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches
2010
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides
2006
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides
2005
AUTOMATED ASSESSMENT OF TIME-DEPENDENT INHIBITION OF HUMAN CYTOCHROME P450 ENZYMES USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ANALYSIS
2005
The pivotal role of hepatocytes in drug discovery
2006
Time-dependent CYP inhibition
2007
The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting
2006