Citation Impact
Citing Papers
Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis
2009
Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages
2014
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
2013 StandoutNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
2014
Effective treatment of severe COVID-19 patients with tocilizumab
2020 Standout
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
2015
Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo
2014
K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling
2015
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
2019
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
2018
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
2016
Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
2021 StandoutNobel
T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow
2017 StandoutNobel
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
2012
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
2018
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages
2018
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
Recovery of an Antiviral Antibody Response following Attrition Caused by Unrelated Infection
2014
Phenotypic Characterization of Autoreactive B Cells—Checkpoints of B Cell Tolerance in Patients with Systemic Lupus Erythematosus
2009
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Matrix metalloproteinases and the regulation of tissue remodelling
2007 Standout
Inflammation and cancer
2002 StandoutNature
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
2013
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Necroptosis and its role in inflammation
2015 StandoutNature
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
The role of B cells in atherosclerosis
2018
Bacterial Exotoxins and the Inflammasome
2015
Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
2014
SNIPERs—Hijacking IAP activity to induce protein degradation
2019
Mechanism and Regulation of NLRP3 Inflammasome Activation
2016 Standout
Death by TNF: a road to inflammation
2022
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
2018
Apoptotic Caspases: Multiple or Mistaken Identities?
2018
Activation and regulation of the inflammasomes
2013 Standout
Necroptosis in the Pathophysiology of Disease
2019
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
2015
Colony-stimulating factors in inflammation and autoimmunity
2008
The changing landscape of atherosclerosis
2021 StandoutNature
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
2015
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
2013
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
2009
Comparing the effects of different cell death programs in tumor progression and immunotherapy
2018
The molecular machinery of regulated cell death
2019 Standout
Tumor Necrosis Factor-α Blockade: A Novel Therapy for Rheumatic Disease
2002
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
FcγRIIB, FcγRIIIB, and systemic lupus erythematosus
2010
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Fcγ receptors as regulators of immune responses
2007 Standout
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Targeting the NLRP3 inflammasome in inflammatory diseases
2018
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
2013
Mechanisms of inflammasome activation: recent advances and novel insights
2015
Metazoan MicroRNAs
2018 Standout
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
2013
Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
2012
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Intra‐articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders
2008
Systemic Lupus Erythematosus
2011 Standout
BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination
2017
G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
2009
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
2011
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Targeting B Cells and Antibody in Transplantation
2011
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
2014
Regulated necrosis: disease relevance and therapeutic opportunities
2016
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
In search of partners: linking extracellular proteases to substrates
2007
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
2014
Necroptosis in development, inflammation and disease
2016
Mechanisms and Functions of Inflammasomes
2014 Standout
Expanding perspectives on the significance of mitophagy in cancer
2017
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
2014
Mitochondria as multifaceted regulators of cell death
2019 Standout
Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment
2019
MicroRNA-140 plays dual roles in both cartilage development and homeostasis
2010
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
2014
Osteoarthritis
2019 Standout
2014
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Human Monocytes Engage an Alternative Inflammasome Pathway
2016
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
2014
Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis
2009 Standout
Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI
2011
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
2018
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Autoimmunity and Anti-TNF-α Agents
2005
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
2014
Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
2012
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
Cytoprotective metal-organic frameworks for anaerobic bacteria
2018 StandoutNobel
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
2019 Standout
Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH
2020
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
2014
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Mitochondrial DNA in innate immune responses and inflammatory pathology
2017
Post-traumatic osteoarthritis: from mouse models to clinical trials
2013
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
2003
Cytokine Storm
2020 Standout
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Single Crystals Heterogeneity Impacts the Intrinsic and Extrinsic Properties of Metal–Organic Frameworks
2021 StandoutNobel
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
2019
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
2014
cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
2013
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5
2015
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen, Candida albicans
2014
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
2017
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice
2015
Initiation and perpetuation of NLRP 3 inflammasome activation and assembly
2015
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production
2013
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling
2014
Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells
2011
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
2019
Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells
2013
Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis
2002
Regulation of inflammasome activation
2015
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Kate E. Lawlor being referenced
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
Distinct cell-specific control of autoimmunity and infection by FcγRIIb
2008
Critical role for granulocyte colony-stimulating factor in inflammatory arthritis
2004
Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion
2018
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
2017
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
2015
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
2018
Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice
2014
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
2013
Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?
2013
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
2016
FcγRIIb controls bone marrow plasma cell persistence and apoptosis
2007
Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
2016
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
2007
IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans
2018
Severe inflammatory arthritis and lymphadenopathy in the absence of TNF
2001
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
2005 Nature
More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling
2013
Acute CD4+ T lymphocyte–dependent interleukin‐1–driven arthritis selectively requires interleukin‐2 and interleukin‐4, joint macrophages, granulocyte–macrophage colony‐stimulating factor, interleukin‐6, and leukemia inhibitory factor
2005
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
2012
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
2014
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
2014
Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development
2005
Therapeutic Effects of a TANK ‐Binding Kinase 1 Inhibitor in Germinal Center–Driven Collagen‐Induced Arthritis
2018