Standout Papers

Millisecond-timescale, genetically targeted optical control of neural activity 2005 2026 2012 2019 3.3k
  1. Millisecond-timescale, genetically targeted optical control of neural activity (2005)
    Edward S. Boyden, Feng Zhang et al. Nature Neuroscience
  2. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance (2009)
    Vikaas S. Sohal, Feng Zhang et al. Nature
  3. Driving fast-spiking cells induces gamma rhythm and controls sensory responses (2009)
    Jessica A. Cardin, Marie Carlén et al. Nature
  4. Neocortical excitation/inhibition balance in information processing and social dysfunction (2011)
    Ofer Yizhar, Lief E. Fenno et al. Nature
  5. Structural and molecular interrogation of intact biological systems (2013)
    Kwanghun Chung, Jenelle L. Wallace et al. Nature
  6. Optogenetics (2010)
    Karl Deisseroth Nature Methods
  7. The Development and Application of Optogenetics (2011)
    Lief E. Fenno, Ofer Yizhar et al. Annual Review of Neuroscience
  8. Optogenetics in Neural Systems (2011)
    Ofer Yizhar, Lief E. Fenno et al. Neuron
  9. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry (2010)
    Alexxai V. Kravitz, Benjamin Freeze et al. Nature
  10. Optical Deconstruction of Parkinsonian Neural Circuitry (2009)
    Viviana Gradinaru, Murtaza Mogri et al. Science
  11. Optogenetic stimulation of a hippocampal engram activates fear memory recall (2012)
    Xu Liu, Steve Ramirez et al. Nature
  12. Input-specific control of reward and aversion in the ventral tegmental area (2012)
    Stephan Lammel, Byung Kook Lim et al. Nature
  13. Natural Neural Projection Dynamics Underlying Social Behavior (2014)
    Lisa A. Gunaydin, Logan Grosenick et al. Cell
  14. Amygdala circuitry mediating reversible and bidirectional control of anxiety (2011)
    Kay M. Tye, Rohit Prakash et al. Nature
  15. Neural substrates of awakening probed with optogenetic control of hypocretin neurons (2007)
    Antoine Adamantidis, Feng Zhang et al. Nature
  16. Three-dimensional intact-tissue sequencing of single-cell transcriptional states (2018)
    Xiao Wang, William E. Allen et al. Science
  17. Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning (2009)
    Hsing-Chen Tsai, Feng Zhang et al. Science
  18. Optogenetics: 10 years of microbial opsins in neuroscience (2015)
    Karl Deisseroth Nature Neuroscience
  19. Dopamine neurons modulate neural encoding and expression of depression-related behaviour (2012)
    Kay M. Tye, Julie J. Mirzabekov et al. Nature
  20. Molecular and Cellular Approaches for Diversifying and Extending Optogenetics (2010)
    Viviana Gradinaru, Feng Zhang et al. Cell
  21. A skin-inspired organic digital mechanoreceptor (2015)
    Benjamin C. K. Tee, Alex Chortos et al. Science
  22. Encoding of conditioned fear in central amygdala inhibitory circuits (2010)
    Stéphane Ciocchi, Cyril Herry et al. Nature
  23. Calmodulin supports both inactivation and facilitation of L-type calcium channels (1999)
    Roger D. Zühlke, Geoffrey S. Pitt et al. Nature
  24. An optical neural interface:in vivocontrol of rodent motor cortex with integrated fiberoptic and optogenetic technology (2007)
    Alexander M. Aravanis, Liping Wang et al. Journal of Neural Engineering
  25. Astrocytes Control Breathing Through pH-Dependent Release of ATP (2010)
    Alexander V. Gourine, Vitaliy Kasymov et al. Science
  26. Tuning arousal with optogenetic modulation of locus coeruleus neurons (2010)
    Matthew E. Carter, Ofer Yizhar et al. Nature Neuroscience
  27. Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward (2010)
    Mary Kay Lobo, Herbert E. Covington et al. Science
  28. Genetic dissection of an amygdala microcircuit that gates conditioned fear (2010)
    Wulf Haubensak, Prabhat S. Kunwar et al. Nature
  29. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking (2011)
    Garret D. Stuber, Dennis R. Sparta et al. Nature
  30. Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity (1996)
    Karl Deisseroth, Haruhiko Bito et al. Neuron
  31. Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons (2012)
    Sarah Threlfell, Tatjana Lalic et al. Neuron
  32. A causal link between prediction errors, dopamine neurons and learning (2013)
    Elizabeth E. Steinberg, Ronald Keiflin et al. Nature Neuroscience
  33. Advanced CLARITY for rapid and high-resolution imaging of intact tissues (2014)
    Raju Tomer, Ye Li et al. Nature Protocols
  34. In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2 (2007)
    Benjamin R. Arenkiel, João Peça et al. Neuron
  35. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins (2011)
    Joanna Mattis, Kay M. Tye et al. Nature Methods
  36. Ultrafast optogenetic control (2010)
    Lisa A. Gunaydin, Ofer Yizhar et al. Nature Neuroscience
  37. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons (1998)
    Karl Deisseroth, E. Kevin Heist et al. Nature
  38. Optogenetic investigation of neural circuits underlying brain disease in animal models (2012)
    Kay M. Tye, Karl Deisseroth Nature reviews. Neuroscience
  39. Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits (2006)
    Karl Deisseroth, Guoping Feng et al. Journal of Neuroscience
  40. Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells (2004)
    Karl Deisseroth, Hiroki Toda et al. Neuron
  41. Channelrhodopsin-2 and optical control of excitable cells (2006)
    Feng Zhang, Liping Wang et al. Nature Methods
  42. Temporally precise in vivo control of intracellular signalling (2009)
    Raag D. Airan, Kimberly R. Thompson et al. Nature
  43. CLARITY for mapping the nervous system (2013)
    Kwanghun Chung, Karl Deisseroth Nature Methods
  44. Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits (2015)
    Talia N. Lerner, Carrie Shilyansky et al. Cell
  45. Locus coeruleus and dopaminergic consolidation of everyday memory (2016)
    Tomonori Takeuchi, Adrian J. Duszkiewicz et al. Nature
  46. Midbrain circuits for defensive behaviour (2016)
    Philip Tovote, Maria Soledad Esposito et al. Nature
  47. Diverging neural pathways assemble a behavioural state from separable features in anxiety (2013)
    Sung‐Yon Kim, Avishek Adhikari et al. Nature
  48. Integration of optogenetics with complementary methodologies in systems neuroscience (2017)
    Christina K. Kim, Avishek Adhikari et al. Nature reviews. Neuroscience
  49. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation (2019)
    Mitchell H. Murdock, Puja K. Parekh et al. Science
  50. Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice (2015)
    Alexander J. Yeh, John S. Ho et al. Nature Methods
  51. Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors (2015)
    Joshua H. Jennings, Randall L. Ung et al. Cell
  52. Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior (2015)
    Emily Ferenczi, Kelly A. Zalocusky et al. Science
  53. Next-generation probes, particles, and proteins for neural interfacing (2017)
    Jonathan Rivnay, Huiliang Wang et al. Science Advances
  54. Gating of social reward by oxytocin in the ventral tegmental area (2017)
    Lin W. Hung, Sophie Neuner et al. Science
  55. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer (2015)
    Joan Font-Burgada, Shabnam Shalapour et al. Cell
  56. Cortical layer–specific critical dynamics triggering perception (2019)
    James H. Marshel, Timothy A. Machado et al. Science
  57. A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System (2018)
    Johannes W. de Jong, Iskra Pollak Dorocic et al. Neuron

Immediate Impact

18 by Nobel laureates 69 from Science/Nature 112 standout
Sub-graph 1 of 21

Citing Papers

Exploring tissue architecture using spatial transcriptomics
2021 StandoutNature
A molecular cell atlas of the human lung from single-cell RNA sequencing
2020 StandoutNature
33 intermediate papers

Works of Karl Deisseroth being referenced

Three-dimensional intact-tissue sequencing of single-cell transcriptional states
2018 StandoutScience
Structural and molecular interrogation of intact biological systems
2013 StandoutNature
and 17 more

Author Peers

Author Last Decade Papers Cites
Karl Deisseroth 57168 35696 23344 414 85.6k
Fred H. Gage 53643 16914 61065 742 143.0k
György Buzsáki 60209 67965 7854 404 84.0k
Robert C. Malenka 48531 22328 27348 258 66.4k
Karel Svoboda 28053 18932 13268 189 46.5k
Solomon H. Snyder 57757 5330 73879 976 140.4k
Eric R. Kandel 46352 23252 31224 483 75.4k
Bert Sakmann 45425 23565 28422 264 58.7k
Carl W. Cotman 33526 10852 27855 659 76.2k
Paul Greengard 51642 6772 69535 956 111.1k
R. S. J. Frackowiak 11682 69156 4846 531 107.3k

All Works

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2026