Citation Impact
Citing Papers
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray Structures
2018
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
2014 Standout
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations
2017
Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference
2015 StandoutNobel
From G Protein-coupled Receptor Structure Resolution to Rational Drug Design
2015
Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
2012
Agonist-bound structures of G protein-coupled receptors
2012
A crystal clear solution for determining G-protein-coupled receptor structures
2012
Opportunities for therapeutic antibodies directed at G-protein-coupled receptors
2017
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ
2013 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
Metabotropic glutamate receptors as drug targets: what's new?
2014
Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore
2017 StandoutNobel
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets
2011
Pocketome: an encyclopedia of small-molecule binding sites in 4D
2011
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
How Ligands Illuminate GPCR Molecular Pharmacology
2017
Molecular Dynamics Simulation for All
2018 Standout
Interaction between microbiota and immunity in health and disease
2020 Standout
Emerging paradigms in GPCR allostery: implications for drug discovery
2013
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
2018 StandoutNobel
Recent developments in biased agonism
2013 Nobel
Biological roles of glycans
2016 Standout
Insight into the binding mode and the structural features of the pyrimidine derivatives as human A2A adenosine receptor antagonists
2013
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
2013 Standout
A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution
2016
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization
2017 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Drug repurposing: progress, challenges and recommendations
2018 Standout
A Molecular Pharmacologist’s Guide to G Protein–Coupled Receptor Crystallography
2015
A new era of GPCR structural and chemical biology
2012 StandoutNobel
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
2012 Nature
Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study
2012 StandoutNobel
Recent advances in engineering microbial rhodopsins for optogenetics
2015 StandoutNobel
Uncovering the intimate relationship between lipids, cholesterol and GPCR activation
2011
Stabilizing membrane proteins through protein engineering
2013
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
2012 StandoutNobel
Structure of the agonist-bound neurotensin receptor
2012 Nature
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation
2016
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
2012 Nature
Adenosine receptors as drug targets — what are the challenges?
2013
Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling
2016
Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function
2013
The Use of GPCR Structures in Drug Design
2011
Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists
2011
G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions
2012
Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques
2011
Post-expression strategies for structural investigations of membrane proteins
2015
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
2014 Standout
Structures of G protein-coupled receptors reveal new opportunities for drug discovery
2015
Molecular signatures of G-protein-coupled receptors
2013 Nature
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
2016
Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists
2016
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2013 Standout
Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications
2016 Standout
The Current State of Peptide Drug Discovery: Back to the Future?
2017
Graphene/Cu Nanoparticle Hybrids Fabricated by Chemical Vapor Deposition As Surface-Enhanced Raman Scattering Substrate for Label-Free Detection of Adenosine
2015
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Structure of the adenosine A2A receptor bound to an engineered G protein
2016 Nature
Overview of pharmacological activities ofAndrographis paniculataand its major compound andrographolide
2018 Standout
Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
2012 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Design, Synthesis, and Biological Evaluation of Potent Dual Agonists of Nuclear and Membrane Bile Acid Receptors
2014
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Activation mechanism of theβ2-adrenergic receptor
2011
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5
2019
Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases: Recent Advances and Successes
2012
Structure-Function of the G Protein–Coupled Receptor Superfamily
2012
Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms
2013
Natural product and natural product derived drugs in clinical trials
2014 Standout
Ligand and Decoy Sets for Docking to G Protein-Coupled Receptors
2011
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors
2016
Current Assessment of Docking into GPCR Crystal Structures and Homology Models: Successes, Challenges, and Guidelines
2012
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Works of K.A. Bennett being referenced
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu 5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)
2015
When simple agonism is not enough: Emerging modalities of GPCR ligands
2010
Intracellular allosteric antagonism of the CCR9 receptor
2016 Nature
Thermostabilisation of an Agonist-Bound Conformation of the Human Adenosine A2A Receptor
2011
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
2011 Nature
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
2014 Nature
Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine
2011
Structures of mGluRs shed light on the challenges of drug development of allosteric modulators
2014
Pharmacology and Structure of Isolated Conformations of the Adenosine A2A Receptor Define Ligand Efficacy
2013