Citation Impact
Citing Papers
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
2011
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Regulatory anatomy of the murine interleukin-2 gene
1990
Self-reactive γδ T cells are eliminated in the thymus
1990 Nature
The T cell receptor Vβ6 domain imparts reactivity to the Mls-1a antigen
1989
Molecular and Cellular Events of T Cell Development
1989
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
A unified model for T cell antigen recognition and thymic selection of the T cell repertoire
1991
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
The Development of Functionally Responsive T Cells
1992
Thymic cortical epithelial cells lack full capacity for antigen presentation
1989 Nature
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
2010 Standout
Thymic selection revisited: how essential is it?
2003
A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition
1988
Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells
1991
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
1988 Nature
Immunohistochemical Study of Normal Skin of HIV-1—Infected Patients Shows No Evidence of Infection of Epidermal Langerhans Cells by HIV
1989
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
1993 StandoutNature
CD 69 expression during selection and maturation of CD4+8+ thymocytes
1993
Mice lacking MHC class II molecules
1991
A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2
1990 Nature
T-cell antigen receptor genes and T-cell recognition
1988 StandoutNature
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Signals involved in thymocyte positive and negative selection
1999
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
1991 StandoutNobel
The effects of MHC gene dosage and allelic variation on T cell receptor selection
1990
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells
2012
Positive Selection of TcRαβ Thymocytes: Is Cortical Thymic Epithelium an Obligatory Participant in the Presentation of Major Histocompatibility Complex Protein?
1993
Towards an integrated view of thymopoiesis
1991
T cell receptor antagonist peptides induce positive selection
1994 Standout
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
1995
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells
1989 StandoutNatureNobel
Constructing polycompetitor cDNAs for quantitative PCR
1993
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
1996 Nature
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
2010
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
1997 Standout
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior#
1989
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.
1989 Nobel
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
1998
Engineered secreted T-cell receptor alpha beta heterodimers.
1991
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
1984
The Murine T Cell Antigen Receptor and Associated Structures
1984 StandoutNobel
The human T-cell receptor α-chain gene maps to chromosome 14
1985 StandoutNatureNobel
A third type of murine T-cell receptor gene
1984 Nature
Peripheral Selection of the T Cell Repertoire
1991 Science
A Nondeletional Mechanism of Thymic Self Tolerance
1989 StandoutScienceNobel
Identification of antigen receptor-associated structures on murine T cells
1985 StandoutNatureNobel
Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
1993
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Selecting T Cell Receptors with High Affinity for Self-MHC by Decreasing the Contribution of CD8
1992 Science
Self-Nonself Discrimination by T Cells
1990 Science
The Role of the T3/Antigen Receptor Complex in T-Cell Activation
1986
Cell Surface Structures Involved in T Cell Activation
1984
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
1997
Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.
1990
Transcription Mediated by NFAT Is Highly Inducible in Effector CD4+ T Helper 2 (Th2) Cells but Not in Th1 Cells
1997
Limited diversity of the rearranged T-cell γ gene
1985 StandoutNatureNobel
Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.
1989 StandoutNobel
Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain.
1991
Developmental regulation of T-cell receptor gene expression
1985 StandoutNatureNobel
Cytokine transcriptional events during helper T cell subset differentiation.
1996
Interleukin 4 induces membrane Thy-1 expression on normal murine B cells.
1988
Primary structure of human T-cell receptor α-chain
1984 Nature
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.
1987 StandoutNobel
Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.
1992
Thymic Requirement for Clonal Deletion During T Cell Development
1989 Science
Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone
1987 StandoutNatureNobel
Early Events in T-Cell Maturation
1987
Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants
1985 StandoutNatureNobel
Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.
1988
Transcription of the interleukin 4 gene is regulated by multiple promoter elements.
1993
Unusual organization and diversity of T-cell receptor a-chain genes
1985 StandoutNatureNobel
Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid
1996 StandoutScienceNobel
Biosynthesis and processing of murine T-cell antigen receptor
1984 StandoutNobel
Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins
1996 StandoutScienceNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors
1991 StandoutScienceNobel
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.
1986
Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.
1985
Characterization of T Cell Receptor Gamma Chain Expression in a Subset of Murine Thymocytes
1986 Science
Identification of a T3-Associated γδ T Cell Receptor on Thy-1 + Dendritic Epidermal Cell Lines
1987 Science
Structure, Function, and Serology of the T-Cell Antigen Receptor Complex
1987 StandoutNobel
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus
1987 StandoutNobel
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.
1990
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
1988 StandoutNatureNobel
The Primary Immunodeficiencies
1984
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.
1984
Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.
1993
Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.
1993
The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells
1987 Science
Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen
2000
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
1998
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.
1993 StandoutNobel
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.
1984 StandoutNobel
Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity
1979 StandoutNobel
Works of Jonathan Kaye being referenced
B and T Lymphocyte Attenuator Tempers Early Infection Immunity
2009
Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice
1989
Quantitative variation in la antigen expression plays a central role in immune regulation
1984
Differentiation of an immature T cell line: A model of thymic positive selection
1992
Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation
1994
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
1989 Nature
B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation
2007
A role for Ras signaling in coreceptor regulation during differentiation of a double-positive thymocyte cell line.
1997
In vivo and in vitro clonal deletion of double-positive thymocytes.
1992
A T cell receptor V alpha region selectively expressed in CD4+ cells.
1990
Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1.
1984
Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.
1995
Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
1984
The alpha- and beta-subunits of a murine T cell antigen/Ia receptor have a molecular weight of 31,000 in the absence of N-linked glycosylation.
1984
Functional Analysis of B and T Lymphocyte Attenuator Engagement on CD4+ and CD8+ T Cells
2005
Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.
1983
Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection
1997
An Inhibitory Ig Superfamily Protein Expressed by Lymphocytes and APCs Is Also an Early Marker of Thymocyte Positive Selection
2004
The L3T4 molecule is part of the helper T-cell antigen/Ia recognition complex
1987
The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia.
1984
Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition
1992
The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts.
1981
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)
1977
Immunogenicity. I. Use of Peptide Libraries to Identify Epitopes That Activate Clonotypic CD4+ T Cells and Induce T Cell Responses to Native Peptide Ligands
1999