Standout Papers
Citation Impact
Citing Papers
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
2010 Science
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
2001
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
2014
Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages
2014
LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
2011
Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
2003
Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans
2002 Science
Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway
2003 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
2004
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
2014
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
2003
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
2006
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
2015
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
2017
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
2013
Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
2013
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
2013
Physiological functions of the HECT family of ubiquitin ligases
2009
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
2005
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
2003
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP
2015
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
2011 Nature
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
2002
Yes-associated protein regulates the hepatic response after bile duct ligation
2012
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
2002
MicroRNAs
2004 Standout
No death without life: vital functions of apoptotic effectors
2008
Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis
2005
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
2014
Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction
2002
Necroptosis and its role in inflammation
2015 StandoutNature
Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac
2003
Filling out the Hippo pathway
2007
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
2009 Standout
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
Lessons from Nature: microRNA-based shRNA libraries
2006
An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila
2000
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
2002
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo
2003
pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer
2007
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
2015 Nature
The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway
2008
Survivin, versatile modulation of cell division and apoptosis in cancer
2003
Diversity in the Mechanisms of Neuronal Cell Death
2003
Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
2014
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
2001
Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation
2004
SNIPERs—Hijacking IAP activity to induce protein degradation
2019
Death by TNF: a road to inflammation
2022
Chemotherapy: targeting the mitochondrial cell death pathway
2002
A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β
2009
c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling
2010
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains
2009
Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein
2002
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents
2004
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
2003
Structural Basis for the Inhibition of Caspase-3 by XIAP
2001
The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)
2016
Shedding light on Merlin's wizardry
2007
Promoting apoptosis as a strategy for cancer drug discovery
2005
Virus Inhibition of RIP3-Dependent Necrosis
2010
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
2004
Shared Principles in NF-κB Signaling
2008 Standout
The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism
2003
Molecular mechanism and function of CD40/CD40L engagement in the immune system
2009
Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing
2015
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
The Many Roles of FAS Receptor Signaling in the Immune System
2009
Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition
2003
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
2003
Necroptosis in the Pathophysiology of Disease
2019
Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation
2010
Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release
2001
Use of Fluorescently Labeled Caspase Inhibitors as Affinity Labels to Detect Activated Caspases
2002
Caspase activation and apoptosis in response to proteasome inhibitors
2005
The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif
2002
Pharmacological manipulation of Bcl-2 family members to control cell death
2005
Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis
2009
Mitochondrial Release of Pro-apoptotic Proteins
2004
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
2018
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Delineation of a Fat tumor suppressor pathway
2006
tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane
2002
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFβ-TRCP
2010
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
2013
Do inducers of apoptosis trigger caspase-independent cell death?
2005
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
2012
Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis
2005
The Apaf-1 apoptosome: a large caspase-activating complex
2002
Cell Death
2004 Standout
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion
2015
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria
2002
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
2002
Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway
2006
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
2010
Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells
2004
The biochemistry of apoptosis
2000 StandoutNature
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
2011
Apoptotic mechanisms in the control of erythropoiesis
2004
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
2002
Toxic proteins released from mitochondria in cell death
2004
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
2005
The Hippo Signaling Pathway in Development and Cancer
2010 Standout
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
2013
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
2010
Cell Death in Pancreatitis
2005
ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway
2004
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
2003
MicroRNA Pathways in Flies and Worms
2003 StandoutNobel
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
2003
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Caspase-independent cell death: leaving the set without the final cut
2008
The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control
2008
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
2013
Death receptors in chemotherapy and cancer
2004
TEAD mediates YAP-dependent gene induction and growth control
2008 Standout
Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α
2013
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
2012
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
2011
Apoptosis-based therapies
2002
Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
2016
Caspase Functions in Cell Death and Disease
2013 Standout
The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation
2015
cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination
2008
Mitochondria, the killer organelles and their weapons
2002
Emerging roles for Lys11-linked polyubiquitin in cellular regulation
2011
β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w
2005
cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
2011
The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
2010
Programmed Anuclear Cell Death Delimits Platelet Life Span
2007
Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis
2005
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
2009
Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro
2002
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
2000 Nature
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
2014
CRISPR-mediated direct mutation of cancer genes in the mouse liver
2014 Nature
Cell Death Inhibition
2001
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
2007 Standout
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
2011 Nature
IAP proteins: blocking the road to death's door
2002
Death receptor signal transducers: nodes of coordination in immune signaling networks
2009
A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death
2001
A Central Role for Bid in Granzyme B-induced Apoptosis
2004
Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA
2002
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
2007
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
2014 Nature
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells
2007
Hippo signaling in organ size control
2007
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
2005
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
2003
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis
2015
Drosophila p53 Binds a Damage Response Element at the reaper Locus
2000
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
2000 Standout
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Accessory subunits are integral for assembly and function of human mitochondrial complex I
2016 Nature
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
2000
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
2002
Mechanisms of cytochrome c release from mitochondria
2006
Death and anti-death: tumour resistance to apoptosis
2002 Standout
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
2002
Apoptosis in the development and maintenance of the immune system
2003
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liver
2010
Apoptosis without caspases: an inefficient molecular guillotine?
1999
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
2014
Redundant cell death mechanisms as relics and backups
2005
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
2005
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
2009
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
2012
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
2008
The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
2007
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
2014
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor
2001
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
2000
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
2011 Nature
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
2003 Nature
Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis
2003
Growth Regulation: A Beginning for the Hippo Pathway
2006
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
The Apoptosome: Physiological, Developmental, and Pathological Modes of Regulation
2006
Dysregulation of apoptosis genes in hematopoietic malignancies
2002
Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes
2004
AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis
2002
Mitochondrial endonuclease G is important for apoptosis in C. elegans
2001 Nature
The mitochondrial death squad: hardened killers or innocent bystanders?
2005
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
2001 Nature
Developmental apoptosis in C. elegans: a complex CEDnario
2006
A Unified Model for Apical Caspase Activation
2003
Expression of Yes-associated protein in common solid tumors
2008
Living with death: the evolution of the mitochondrial pathway of apoptosis in animals
2008
The role of BH3-only proteins in the immune system
2005
The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
2011
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Enhanced Cytoprotective Effects of the Inhibitor of Apoptosis Protein Cellular IAP1 through Stabilization with TRAF2
2009
Endonuclease G is an apoptotic DNase when released from mitochondria
2001 Nature
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
2007
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
2005
Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination
2003
RIPK3 as a potential therapeutic target for Gaucher's disease
2014
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
2004
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
2014
Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells
2013
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
2000 Nature
Structural Basis of Caspase-7 Inhibition by XIAP
2001
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Structural basis of IAP recognition by Smac/DIABLO
2000 Nature
A crucial role of WW45 in developing epithelial tissues in the mouse
2008
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
2011
Apoptotic and necrotic cell death induced by death domain receptors
2001
Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides
2001
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
2011
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
TNF-α Induces Two Distinct Caspase-8 Activation Pathways
2008
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
2002
The functions of animal microRNAs
2004 StandoutNatureNobel
Dimerization and Processing of Procaspase-9 by Redox Stress in Mitochondria
2004
Regulation of death receptor signaling by the ubiquitin system
2009
Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals
2007 Standout
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
Mechanisms of Apoptosis
2000
Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
2017
CD95's deadly mission in the immune system
2000 Nature
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
2011
Induction of p53‐independent apoptosis by the BH3‐only protein ITM2Bs
2004
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
2014
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
The Oscar-worthy role of Myc in apoptosis
2006
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
2009
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
2014
Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor
2004
In vivo regulation of Yorkie phosphorylation and localization
2008
Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition
2005
Clues from cell metabolism
2010 StandoutNatureNobel
Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1β Production
2013
Control of Life-or-Death Decisions by RIP1 Kinase
2013
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures
2014
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
2003
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
2014
Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
2004
Molecular biology of Bax and Bak activation and action
2010
Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
2012
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
2003
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury
2013
Role of MicroRNAs in Plant and Animal Development
2003 StandoutScienceNobel
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains
2009
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
2010
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Structural Basis of Caspase Inhibition by XIAP
2001
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
2014
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis
2008
The Role of Ubiquitin in NF-κB Regulatory Pathways
2009
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
Inhibition of Translation and Induction of Apoptosis by Bunyaviral Nonstructural Proteins Bearing Sequence Similarity to Reaper
2003
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene
2003
Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice
2004
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death
2005
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
2003
Hippo signaling regulatesDrosophilaintestine stem cell proliferation through multiple pathways
2010
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
2019
Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death
2003
Novel YAP1‐TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma
2013
Apoptosome-deficient Cells Lose Cytochromecthrough Proteasomal Degradation but Survive by Autophagy-dependent Glycolysis
2008
Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis
2006
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
2006
cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
2013
RING Domain E3 Ubiquitin Ligases
2009 Standout
Dimer formation drives the activation of the cell death protease caspase 9
2001
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
2014
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen, Candida albicans
2014
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
2008
An alternative, nonapoptotic form of programmed cell death
2000
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
2010
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
2017
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
2001
Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon
2006
The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function
2002
Apoptosis - the p53 network
2003
TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways
2020
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
2003
Exogenous Smac Induces Competence and Permits Caspase Activation in Sympathetic Neurons
2002
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
2010
Mitochondrial Complex I
2013
The expanding role of mitochondria in apoptosis.
2001 Standout
Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
2014
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling
2014
Opposite Feedbacks in the Hippo Pathway for Growth Control and Neural Fate
2013 Science
The Ubiquitin Code
2012 Standout
FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
2014
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
2004 Science
Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells
2013
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process
2001
Real-time single cell analysis of Smac/DIABLO release during apoptosis
2003
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors
2005
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
2014
Cytochrome c release from mitochondria proceeds by a two-step process
2002
Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation
2009
The Role of Mitochondria in Apoptosis
2009 Standout
Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
2001
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
2014
The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
2010
Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance
2004
Works of John Silke being referenced
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs
2018
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
2017
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
2017
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
2015
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
2018
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
2018
HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death
2014
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
2008
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach
2006
Cell death: Shadow Baxing
1998
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
2013
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
2011
The Drosophila caspase DRONC is regulated by DIAP1
2000
Mammalian mitochondrial IAP binding proteins
2003
IAPs limit activation of RIP kinases by TNF receptor 1 during development
2012
Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease
2007
Caspase inhibitors
1999
Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment
2008
Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling
2013
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
2000 Standout
RIPK1 is not essential for TNFR1-induced activation of NF-κB
2009
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
2016
Asymmetric Recruitment of cIAPs by TRAF2
2010
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
2002 Nature
NF-κB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2
2007
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
2001
Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis
2004
Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
2009
Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
2011
The diverse role of RIP kinases in necroptosis and inflammation
2015
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
2011
IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans
2018
The regulation of TNF signalling: what a tangled web we weave
2011
Linear ubiquitination prevents inflammation and regulates immune signalling
2011 Nature
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
2018
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
2012
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
2009
Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation
2013
XIAP discriminates between type I and type II FAS-induced apoptosis
2009 Nature
Engineered Exosomes as Vehicles for Biologically Active Proteins
2017
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
2007
IAP gene deletion and conditional knockout models
2014
Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins
2008
Evolutionary divergence of the necroptosis effector MLKL
2016
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
2012
HtrA2/Omi, a Sheep in Wolf's Clothing
2003
The intersection of cell death and inflammasome activation
2016
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
2009
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
2004
TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis
2009
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
2006
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
2013
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
2014
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
2009
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
2005
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
2016
The FLIP Side of Life
2013
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
2014
In vivo control of B‐cell survival and antigen‐specific B‐cell responses
2010
Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?
2000
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death
2022
Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9
2001
IAPs – the ubiquitin connection
2005
The polycomb repressive complex 2 governs life and death of peripheral T cells
2014
Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis
2015
IAPs, RINGs and ubiquitylation
2005
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
2011
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites
2002
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
2008
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins
2002
Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis
2001