Standout Papers

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs 1971 2026 1989 2007 6.8k
  1. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs (1971)
    John R. Vane Nature New Biology
  2. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation (1976)
    Salvador Moncada, Ryszard J. Gryglewski et al. Nature
  3. CYCLOOXYGENASES 1 AND 2 (1998)
    John R. Vane, Y.S. Bakhle et al. The Annual Review of Pharmacology and Toxicology
  4. Regulatory Functions of the Vascular Endothelium (1990)
    Franklin H. Epstein, John R. Vane et al. New England Journal of Medicine
  5. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. (1993)
    Jane A. Mitchell, Pravit Akarasereenont et al. Proceedings of the National Academy of Sciences
  6. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. (1978)
    Salvador Moncada, John R. Vane Pharmacological Reviews
  7. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis (1999)
    Timothy D. Warner, Francesco Giuliano et al. Proceedings of the National Academy of Sciences
  8. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. (1988)
    Gilberto De Nucci, Ranjeny Thomas et al. Proceedings of the National Academy of Sciences
  9. Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls (1979)
    Salvador Moncada, John R. Vane New England Journal of Medicine
  10. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. (1994)
    John R. Vane, Jane A. Mitchell et al. Proceedings of the National Academy of Sciences
  11. The mechanism of action of aspirin (2003)
    John R. Vane, R M Botting Thrombosis Research
  12. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides (1976)
    Ryszard J. Gryglewski, Stuart Bunting et al. Prostaglandins
  13. Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation (1976)
    Stuart Bunting, Salvador Moncada et al. Prostaglandins
  14. Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen (1971)
    S. H. Ferreira, Salvador Moncada et al. Nature New Biology
  15. Prostaglandins: Their Disappearance from and Release into the Circulation (1967)
    S. H. Ferreira, John R. Vane Nature
  16. Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs (1969)
    Priscilla J. Piper, John R. Vane Nature
  17. HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION (1977)
    Salvador Moncada, E.A. Higgs et al. The Lancet
  18. A SENSITIVE METHOD FOR THE ASSAY OF 5‐HYDROXYTRYPTAMINE (1957)
    John R. Vane British Journal of Pharmacology and Chemotherapy
  19. New insights into the mode of action of anti-inflammatory drugs (1995)
    John R. Vane, R M Botting Inflammation Research
  20. The chemical structure of prostaglandin X (prostacyclin) (1976)
    Roy A. Johnson, Douglas R. Morton et al. Prostaglandins
  21. Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol) (1972)
    R J Flower, John R. Vane Nature
  22. Anti-inflammatory drugs and their mechanism of action (1998)
    John R. Vane, R M Botting Inflammation Research
  23. THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES (1971)
    Piper Pj, John R. Vane Annals of the New York Academy of Sciences
  24. Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium (1977)
    Salvador Moncada, A.G. Herman et al. Thrombosis Research
  25. Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets (1977)
    J.E. Tateson, Salvador Moncada et al. Prostaglandins
  26. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation (1976)
    Salvador Moncada, Ryszard J. Gryglewski et al. Prostaglandins
  27. The release and fate of vaso‐active hormones in the circulation (1969)
    John R. Vane British Journal of Pharmacology
  28. Prostaglandins released by the Spleen (1968)
    Norbert Gilmore, John R. Vane et al. Nature
  29. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides (1976)
    Philip Needleman, Salvador Moncada et al. Nature
  30. A new approach to anti-inflammatory drugs (1979)
    G.A. Higgs, Roderick J. Flower et al. Biochemical Pharmacology
  31. Inflammation and the mechanism of action of anti‐inflammatory drugs (1987)
    John R. Vane, Regina M. Botting The FASEB Journal
  32. Inactivation of Prostaglandins by the Lungs (1970)
    Priscilla J. Piper, John R. Vane et al. Nature
  33. Conversion of Angiotensin I to Angiotensin II (1967)
    K. K. F. NG, John R. Vane Nature
  34. THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD (1964)
    John R. Vane British Journal of Pharmacology and Chemotherapy
  35. Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis (1972)
    R.J. Flower, R Gryglewski et al. Nature New Biology
  36. New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs (1974)
    S. H. Ferreira, John R. Vane Annual Review of Pharmacology
  37. UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS (1978)
    Salvador Moncada, John R. Vane British Medical Bulletin
  38. Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid (1977)
    Gregory J. Dusting, Salvador Moncada et al. Prostaglandins
  39. Inhibition of prostaglandin biosynthesis (1974)
    Roderick J. Flower, John R. Vane Biochemical Pharmacology
  40. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa (1980)
    Brendan J.R. Whittle, G.A. Higgs et al. Nature
  41. INTRARENAL PROSTAGLANDIN RELEASE ATTENUATES THE RENAL VASOCONSTRICTOR ACTIVITY OF ANGIOTENSIN (1973)
    James W. Aiken, John R. Vane Journal of Pharmacology and Experimental Therapeutics
  42. Prostacyclin is a circulating hormone (1978)
    Salvador Moncada, Ryszard Korbut et al. Nature
  43. Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species (1978)
    Brendan J.R. Whittle, Salvador Moncada et al. Prostaglandins
  44. PHOSPHOLIPASE A2 ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS (1978)
    Geoffrey J. Blackwell, R.J. Flower et al. British Journal of Pharmacology
  45. Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation (1973)
    Salvador Moncada, S. H. Ferreira et al. Nature
  46. : A selective inhibitor of thromboxane synthetase (1977)
    Salvador Moncada, Stuart Bunting et al. Prostaglandins
  47. Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs (1973)
    S. H. Ferreira, Salvador Moncada et al. British Journal of Pharmacology
  48. Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes (1978)
    John A. Salmon, Derek R. Smith et al. Biochimica et Biophysica Acta (BBA) - Enzymology
  49. Fate of Angiotensin I in the Circulation (1968)
    K. K. F. NG, John R. Vane Nature
  50. THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS (1977)
    Geoffrey J. Blackwell, W. G. Duncombe et al. British Journal of Pharmacology
  51. COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6‐OXO‐PROSTAGLANDIN F1α WITH THOSE OF PROSTAGLANDIN E2 IN RATS AND RABBITS (1978)
    J. M. Armstrong, Norman Lattimer et al. British Journal of Pharmacology
  52. The mode of action of aspirin and similar compounds (1976)
    John R. Vane Journal of Allergy and Clinical Immunology

Immediate Impact

16 by Nobel laureates 69 from Science/Nature 120 standout
Sub-graph 1 of 14

Citing Papers

Metabolism of inflammation limited by AMPK and pseudo-starvation
2013 StandoutNature
Origin and physiological roles of inflammation
2008 StandoutNature
3 intermediate papers

Works of John R. Vane being referenced

Eicosanoids in inflammation.
1984
Adventures and excursions in bioassay: the stepping stones to prostacyclin
1983
and 4 more

Author Peers

Author Last Decade Papers Cites
John R. Vane 18230 24332 11826 13018 461 62.4k
Garret A. FitzGerald 8891 14141 7772 11251 482 49.0k
Bengt Samuelsson 10735 14832 9433 12675 422 42.3k
Charles N. Serhan 11927 10448 22091 22849 614 80.3k
Bart Staels 17854 4977 5697 40867 781 77.2k
Pál Pacher 8039 11575 1735 11674 387 43.5k
Frank J. Gonzalez 16492 6690 10156 55848 1.3k 117.1k
Jason D. Morrow 7998 7827 6443 12521 402 41.7k
John A. Oates 4598 7017 3548 5815 339 33.3k
Bruce M. Spiegelman 70072 5506 9392 72203 344 135.0k
Richard Palmer 34327 2334 9928 10365 215 56.7k

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