Citation Impact
Citing Papers
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
TOR Signaling in Growth and Metabolism
2006 Standout
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Base-excision repair of oxidative DNA damage
2007 StandoutNature
TGF-β and cancer
1999
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Tumors are unique organs defined by abnormal signaling and context
2001
Hereditary colorectal cancer syndromes
2005
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Cancer Metastasis: Building a Framework
2006 Standout
SMAD genes in juvenile polyposis
1999
Regulation of cell proliferation by Smad proteins
2002
Genetics of hereditary colorectal cancer
2005
Genetic pathways in colorectal and other cancers
1999
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family
2003
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
PTEN: One Gene, Many Syndromes
2003
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)
2004 Standout
The genetics of FAP and FAP-like syndromes
2006
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
2000
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Putting tumours in context
2001 Standout
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
2001
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Mouse models for colorectal cancer
1999
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
The microenvironment of the tumour–host interface
2001 StandoutNature
Constipation, polyps, or cancer? let PTEN predict your future
2003
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Hereditary Colorectal Cancer
2003 Standout
EMT: 2016
2016 Standout
Genetic predisposition to colorectal cancer
2004
Mutations of the human PTEN gene
2000
Signaling of transforming growth factor‐β family members through Smad proteins
2000
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
1999
TGF-β Tumor Suppression through a Lethal EMT
2016
Oncogenic Ras Represses Transforming Growth Factor-β/Smad Signaling by Degrading Tumor Suppressor Smad4
2001
Role of Transforming Growth Factor-beta Signaling in Cancer
2000
Epithelial-Mesenchymal Transition
2009
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
1999
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
TGF-β signaling by Smad proteins
2000
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Hamartomatous Polyposis Syndromes: Molecular Genetics, Neoplastic Risk, and Surveillance Recommendations
2001
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Principles of Tumor Suppression
2004
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling
2004
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
2010
TGF-β signaling by Smad proteins
2000
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway
2000
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
2000
De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine
2004 Science
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
2002
Self-Renewal and Cancer of the Gut: Two Sides of a Coin
2005 Science
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Pten is essential for embryonic development and tumour suppression
1998 Standout
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells
1999
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
1999
CHASING THE CANCER DEMON
2000
Surfing the p53 network
2000 StandoutNature
Signal Transduction by the TGF-β Superfamily
2002 StandoutScience
Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction
1999
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
1999
Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators
1999 Science
Current View: Intestinal Stem Cells and Signaling
2008
TbetaR-I(6A) is a candidate tumor susceptibility allele.
1999
STEM CELL NICHE: Structure and Function
2005
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
TGF-β and cancer
2005
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
Genetic Testing for Cancer Predisposition
2001
Works of John C. Ringold being referenced
Common Deletion of SMAD4 in Juvenile Polyposis Is a Mutational Hotspot
2002
A Gene for Familial Juvenile Polyposis Maps to Chromosome 18q21.1
1998
Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis
1999
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
1998 Science