Citation Impact
Citing Papers
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
A fluorogenic probe for β-galactosidase activity imaging in living cells
2013
Purine nucleoside phosphorylases: properties, functions, and clinical aspects
2000
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme
2002
Recent advances in selective α1-adrenoreceptor antagonists as antihypertensive agents
2008
Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C
2001
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
2004 Standout
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
Crystal Structure of Calf Spleen Purine Nucleoside Phosphorylase with Two Full Trimers in the Asymmetric Unit: Important Implications for the Mechanism of Catalysis
2004 StandoutNobel
The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans
1997
Purine nucleoside phosphorylase: A target for drug design
1993
Principles of nanoparticle design for overcoming biological barriers to drug delivery
2015 Standout
Prodrug Strategies in Anticancer Chemotherapy
2007
Substitution effect on the hydrofluorination reaction of unsaturated amines in superacid HF/SbF5
2009
Synthesis, structural characterization and in vitro biological screening of some homoleptic copper(II) complexes with substituted guanidines
2011
Effect of pegylation on pharmaceuticals
2003 Standout
Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir
2016 StandoutNobel
Highly Potent Naphthofuran‐Based Retinoic Acid Receptor Agonists
2009
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
2001
Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion
2001
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Calf spleen purine nucleoside phosphorylase: purification, sequence and crystal structure of its complex with an N(7)‐acycloguanosine inhibitor
1995
Copper‐Catalyzed CH Bond Direct Chalcogenation of Aromatic Compounds Leading to Diaryl Sulfides, Selenides, and Diselenides by Using Elemental Sulfur and Selenium as Chalcogen Sources Under Oxidative Conditions
2013
Antibody against poly(ethylene glycol) adversely affects PEG‐asparaginase therapy in acute lymphoblastic leukemia patients
2007
Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs
1999
The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
2013
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase
2005
Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines
2000
The golden age: gold nanoparticles for biomedicine
2011 Standout
An overview on 5α-reductase inhibitors
2009
A novel, facile route to β-fluoroamines by hydrofluorination using superacid HF–SbF5
2007
Development of Pegylated Interferons for the Treatment of Chronic Hepatitis C
2001
The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis ofα-Amino Acid Derived Imidazolines
2001
Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes
2011
Polyphenols: food sources and bioavailability
2004 Standout
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
2012 Standout
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-β-lactamases
2004
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 Å resolution
1997
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
2010 Standout
Chemistry for peptide and protein PEGylation
2002
Ultralow‐Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications
2009 Standout
Tumor-activated Prodrugs—A New Approach to Cancer Therapy
2004
Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates
2003
Effective drug delivery by PEGylated drug conjugates
2003
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Pharmacokinetic Consequences of Pegylation
2006
Recent advances in Sonogashira reactions
2011 Standout
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Facile Total Synthesis of Benzo[b]furan Natural Product XH-14
2009
Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution.
1990
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Purine nucleoside phosphorylase. Structure-activity relationships for substrate and inhibitor properties of N-1-, N-7-, and C-8-substituted analogues; differentiation of mammalian and bacterial enzymes with N-1-methylinosine and guanosine.
1988
3d Transition Metals for C–H Activation
2018 Standout
The Golden Age of Transfer Hydrogenation
2015 Standout
Biologically active quinoline and quinazoline alkaloids part I
2017
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
2013 StandoutNobel
Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom
2011 Standout
Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response
2012
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors
2013
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
1999
Biologically active quinoline and quinazoline alkaloids part II
2018
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Synthesis and Properties of Poly[N-(2-Hydroxypropyl) Methacrylamide] Conjugates of Superoxide Dismutase
2002
Parallel Synthesis of a Multi-Substituted Benzo[b]furan Library
2008
Mitsunobu and Related Reactions: Advances and Applications
2009
Homologation of the Fischer Indolization: A Quinoline Synthesis via Homo‐Diaza‐Cope Rearrangement
2020 StandoutNobel
Phosphine Organocatalysis
2018 Standout
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications
2007 StandoutNobel
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Strategies for enzyme/prodrug cancer therapy.
2001
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
2006
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Electrophilic Cyclization of 2-Chalcogenealkynylanisoles: Versatile Access to 2-Chalcogen-benzo[b]furans
2009
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
The development of anticancer ruthenium(ii ) complexes: from single molecule compounds to nanomaterials
2017 Standout
Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis
2010
Iron-Catalyzed One-Pot 2,3-Diarylquinazolinone Formation from 2-Nitrobenzamides and Alcohols
2013
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
Metalated Heterocycles and Their Applications in Synthetic Organic Chemistry
2004
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: Effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes
2005
Functional Oligothiophenes: Molecular Design for Multidimensional Nanoarchitectures and Their Applications
2009 Standout
Enzyme-Responsive Snap-Top Covered Silica Nanocontainers
2008 StandoutNobel
Pd-Catalyzed π-Chelation Assisted ortho-C–H Activation and Annulation of Allylarenes with Internal Alkynes
2013
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
An Activity-Based Near-Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues
2012
Iron and Copper Salts in the Synthesis of Benzo[b]furans
2010
Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
2004 Standout
Polymer–drug conjugation, recent achievements and general strategies
2007
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Diversified facile synthesis of benzimidazoles, quinazolin-4(3H)-ones and 1,4-benzodiazepine-2,5-diones via palladium-catalyzed transfer hydrogenation/condensation cascade of nitro arenes under microwave irradiation
2015
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Antibody-directed enzyme prodrug therapy (ADEPT): a review
1997
Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen-Containing (Fluorinated) Polycyclic Systems
2013
Anti‐PEG immunity: emergence, characteristics, and unaddressed questions
2015
An expedient synthesis of 2-substituted naphthalenes from the Baylis–Hillman adducts
2001
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
Recent Advances in the Baylis−Hillman Reaction and Applications
2003 Standout
Synthesis of 2,3-Disubstituted Benzo[b]furans by the Palladium-Catalyzed Coupling ofo-Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization
2005
Synthesis of Heterocycles from Alkyl 3-(Dimethylamino)propenoates and Related Enaminones
2004 Standout
Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy
2017 Standout
Novel sulphonamide derivatives for the treatment of cancer
2000
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Ji‐Wang Chern being referenced
Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug
1999
Downregulation of GSTπ expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis
2009
Poly(ethylene glycol) modification of β-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs
1997
The β-Carboline Analog Mana-Hox Causes Mitotic Aberration by Interacting with DNA
2005
Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate
1991
Microwave‐Assisted Cross‐Coupling for the Construction of Diaryl Sulfides
2011
Design and Synthesis of Water-Soluble Glucuronide Derivatives of Camptothecin for Cancer Prodrug Monotherapy and Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
1999
Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy.
1992
Synthesis and Cytotoxic Evaluation of Substituted Sulfonyl-N-hydroxyguanidine Derivatives as Potential Antitumor Agents
1997
Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine.
1986
A convenient synthesis of naturally occurring benzofuran ailanthoidol
2001
A new route towards the synthesis of substituted naphthalenes via Friedel–Crafts acylation
2000
Studies on 1,2,4-Benzothiadiazine 1,1-Dioxides VII and Quinazolinones IV: Synthesis of Novel Built-In Hydroxyguanidine Tricycles as Potential Anticancer Agents
1993
Accelerated Clearance of Polyethylene Glycol-Modified Proteins by Anti-Polyethylene Glycol IgM
1999
Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy
2008
Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors.
1986
Efficient Clearance of Poly(ethylene glycol)-Modified Immunoenzyme with Anti-PEG Monoclonal Antibody for Prodrug Cancer Therapy
2000
Studies on Quinazolines. 11. Intramolecular Imidate-Amide Rearrangement of 2-Substituted 4-(ω-Chloroalkoxy)quinazoline Derivatives. 1,3 -O → N Shift of Chloroalkyl Groups via Cyclic 1,3-Azaoxonium Intermediates
2003
Studies on quinazolines IX:1 Fluorination versus 1,2-migration in the reaction of 1,3-bifunctionalized amino-2-propanol with DAST
1998
A Novel Strategy for the Synthesis of Benzofuran Skeleton Neolignans: Application to Ailanthoidol, XH-14, and Obovaten
2002
Efficient microwave‐assisted synthesis of ellipticine through N‐(1,4‐dimethyl‐9H‐carbazol‐3‐ylmethyl)‐N‐ tosylaminoacetaldehyde diethyl acetal
2010
Efficient Preparation of Penicillanate Ester: A Reductive Debromination of Bromopenicillanate Ester and Bromopenicillante-S,S-dioxide Easter with Tri-N-butylphosphine
1988
Studies on Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides. 8. Synthesis and Pharmacological Evaluation of Tricyclic Fused Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides as Potential α1-Adrenoceptor Antagonists
1998
Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase
2001
Nucleosides. IX. Synthesis of PurineN3,5′‐Cyclonucleosides andN3,5′‐Cyclo‐2′,3′‐seconucleosides via Mitsunobu Reaction as TIBO‐like Derivatives
2004
Studies on Quinazolines. VII. Reactions of Anthranilamide with .BETA.-Diketones; New Approaches toward the Synthesis of Tetrahydropyrido(2,1-b)quinazolin-11-one Derivatives.
1998
Discovery of a Novel Series of Quinolone and Naphthyridine Derivatives as Potential Topoisomerase I Inhibitors by Scaffold Modification
2009