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Amyloid fibrils
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Protein Misfolding, Functional Amyloid, and Human Disease
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2002
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Molecular basis for amyloid fibril formation and stability
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Aβ amyloid fibrils possess a core structure highly resistant to hydrogen exchange
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Transmissibility of systemic amyloidosis by a prion-like mechanism
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Inclusion-body myositis
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Molecular basis for insulin fibril assembly
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Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice
2003
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2003
Mapping Aβ Amyloid Fibril Secondary Structure Using Scanning Proline Mutagenesis
2003
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Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
2009
P4‐316: Stabilization of neurotoxic Alzheimer amyloid‐beta oligomers by protein engineering
2011
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Alzheimer's Disease: Genes, Proteins, and Therapy
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Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
2001
Immunotherapy for Alzheimer's disease
2004
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ
2011
Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
2010
Comparison of Alzheimer Aβ(1–40) and Aβ(1–42) amyloid fibrils reveals similar protofilament structures
2009
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid
2011
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
2016
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
2005
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
2005
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
2001
On the lag phase in amyloid fibril formation
2015
Deposition of Monomeric, Not Oligomeric, Aβ Mediates Growth of Alzheimer's Disease Amyloid Plaques in Human Brain Preparations
1999
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Designed amyloid fibers as materials for selective carbon dioxide capture
2013 StandoutNobel
Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism
2011
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease
2001
N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure
2006
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
2013
Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42
2006
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
2002 Standout
Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons
2002
The Development of Amyloid β Protein Deposits in the Aged Brain
2006
Structural Features of the Aβ Amyloid Fibril Elucidated by Limited Proteolysis
2001
Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics
2010 StandoutNobel
Structural properties of Aβ protofibrils stabilized by a small molecule
2005
Self-Assembly of β-Amyloid 42 Is Retarded by Small Molecular Ligands at the Stage of Structural Intermediates
2000 StandoutNobel
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
2002
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
2005
Insights into the Amyloid Folding Problem from Solid-State NMR
2003
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
2020
Folding of the C-terminal bacterial binding domain in statherin upon adsorption onto hydroxyapatite crystals
2006 StandoutNobel
Amyloid Fibril Formation by Aβ16-22, a Seven-Residue Fragment of the Alzheimer's β-Amyloid Peptide, and Structural Characterization by Solid State NMR
2000
A New Structural Model of Aβ40 Fibrils
2011
Chemical Glycoproteomics
2016 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain
2000
Works of Jan Näslund being referenced
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
2001
Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain
1995
Controlling Amyloid β-Peptide Fibril Formation with Protease-stable Ligands
1997
Endogenous Proteins Controlling Amyloid β-Peptide Polymerization
1999
A Nine-transmembrane Domain Topology for Presenilin 1
2005
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
2000
Amyloid fibril formation by pulmonary surfactant protein C
1999
Characterization of the Alzheimer's Disease-associated CLAC Protein and Identification of an Amyloid β-Peptide-binding Site
2004
Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand
1996
Controlling Polymerization of β-Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands
2000
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
2005
Intraneuronal Aβ42 Accumulation in Human Brain
2000
Generation of Alzheimer Amyloid β Peptide through Nonspecific Proteolysis
1997
Unwinding fibril formation of medin, the peptide of the most common form of human amyloid
2007
High‐Resolution Separation of Amyloid β‐Peptides: Structural Variants Present in Alzheimer's Disease Amyloid
1996
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
1998
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.
1994
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.
1994
Quantification of Alzheimer Amyloid β Peptides Ending at Residues 40 and 42 by Novel ELISA Systems
2000
Medin: An integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid
1999
CLAC Binds to Aggregated Aβ and Aβ Fragments, and Attenuates Fibril Elongation
2005