Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Synthetic GPCRs for programmable sensing and control of cell behaviour
2024 Nature
Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes
2004
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
2017
Hallmarks of Cancer: The Next Generation
2011 Standout
Phosphodiesterase 4D and Protein Kinase A Type II Constitute a Signaling Unit in the Centrosomal Area
2001
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Chemokine Networks and Breast Cancer Metastasis
2007
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Cellular and molecular mechanisms of fibrosis
2007 Standout
GENETIC ANALYSIS OF PROTEIN STABILITY AND FUNCTION
1989
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes
2024 StandoutNobel
Characterization of a slow folding reaction for the α subunit of tryptophan synthase
1987
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands
2020
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
2017
Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro
1992
Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding
1995 Standout
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
2001
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
2018
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Engineered Cell-Based Therapeutics: Synthetic Biology Meets Immunology
2019
Molten Globule and Protein Folding
1995
Structural diversity of G protein-coupled receptors and significance for drug discovery
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Mapping the transition state and pathway of protein folding by protein engineering
1989 Nature
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
2020
Catalytic promiscuity and the evolution of new enzymatic activities
1999
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state
1992
ATP-Independent Control of Autotransporter Virulence Protein Transport via the Folding Properties of the Secreted Protein
2011
Computational design of novel protein–protein interactions – An overview on methodological approaches and applications
2022
Cytoskeletal genes regulating brain size
2005
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling
2003
Redesigning the Substrate Specificity of an Enzyme by Cumulative Effects of the Mutations of Non-active Site Residues
1999
Kinetic role of early intermediates in protein folding
1997
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
A model of the molten globule state from molecular dynamics simulations.
1992 StandoutNobel
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
1997 StandoutNobel
[6] Protein engineering in analysis of protein folding pathways and stability
1991
Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination
2016
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
[27] Modification of enzyme catalysis by engineering surface charge
1991
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'
1993
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Directed evolution of an aspartate aminotransferase with new substrate specificities
1998
Roles of mutation and recombination in the evolution of protein thermodynamics
2002 StandoutNobel
Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins
1990
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
A structural view of evolutionary divergence
1999 StandoutNobel
Enzyme Redesign
2001
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Quantification of the hydrophobic interaction by simulations of the aggregation of small hydrophobic solutes in water
2001 StandoutNobel
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Revealing the Architecture of a K + Channel Pore Through Mutant Cycles with a Peptide Inhibitor
1995 StandoutScienceNobel
The PDZ-binding motif of the β 2 -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
2003 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families
1999 Science
De novo design of protein logic gates
2020 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
COMBINES-CID: An Efficient Method for De Novo Engineering of Highly Specific Chemically Induced Protein Dimerization Systems
2019
Limited internal friction in the rate-limiting step of a two-state protein folding reaction
1998 StandoutNobel
Works of James Onuffer being referenced
Myomegalin Is a Novel Protein of the Golgi/Centrosome That Interacts with a Cyclic Nucleotide Phosphodiesterase
2001
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
2002
Chemokines, chemokine receptors and small-molecule antagonists: recent developments
2002
Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells
2012 Nature
Folding of homologous proteins: Conservation of the folding mechanism of the .alpha. subunit of tryptophan synthase from Escherichia coli, Salmonella typhimurium, and five interspecies hybrides
1988
Redesign of the substrate specificity ofescherichia coliaspartate aminotransferase to that ofescherichia colityrosine aminotransferase by homology modeling and site-directed mutagenesis
1995
Alternating arginine-modulated substrate specificity in an engineered tyrosine aminotransferase
1995
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor
2015 Science
Effects of the phenylalanine-22 .fwdarw. leucine, glutamic acid-49 .fwdarw. methionine, glycine-234 .fwdarw. aspartic acid and glycine-234 .fwdarw. lysine mutations on the folding and stability of the .alpha. subunit of tryptophan synthase from Escherichia coli
1986
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
2002
Effect of single amino acid replacements on the folding and stability of dihydrofolate reductase from Escherichia coli
1987
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal
2014
Long-range electrostatic interactions can influence the folding, stability, and cooperativity of dihydrofolate reductase
1989