Standout Papers
- Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. (1996)
- Increased transversions in a novel mutator colon cancer cell line (1998)
- Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers (1998)
- Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability (2000)
Citation Impact
Citing Papers
Comparative lesion sequencing provides insights into tumor evolution
2008
GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon
2009
NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer
2008
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
2009 StandoutNobel
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells
2012
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
2004
Morphology of sporadic colorectal cancer with DNA replication errors
1998
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Altered methylation patterns in cancer cell genomes: Cause or consequence?
2002
Phenotypic plasticity and the epigenetics of human disease
2007 Nature
Mismatch repair defects in cancer
2000
TGF-β and cancer
1999
Microsatellite Instability in Colorectal Cancer
2010 Standout
The history of cancer epigenetics
2004 Standout
Strand-specific Mismatch Repair in Mammalian Cells
1997 StandoutNobel
Role of Transforming Growth Factor β in Human Disease
2000 Standout
DNA methylation in endometrial cancer
2010
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas
1997
Macrophage Migration Inhibitory Factor Promotes Intestinal Tumorigenesis
2005
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
A Novel Mechanism for Regulating Transforming Growth Factor β (TGF-β) Signaling
2001
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Identification of a Second MutL DNA Mismatch Repair Complex (hPMS1 and hMLH1) in Human Epithelial Cells
2000
Going Mad withSmads
1999
Genetic instabilities in human cancers
1998 StandoutNature
Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis
2003
Genetic pathways in colorectal and other cancers
1999
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Alteration of cell growth and morphology by overexpression of transforming growth factor β type II receptor in human lung adenocarcinoma cells
2001
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Structure and function of the components of the human DNA mismatch repair system
2006
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Microsatellite instability: an update
2015
The mismatch repair system is required for S-phase checkpoint activation
2002
Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells
1995
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines
2000
Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair
2002 StandoutNobel
Mutations of the transforming growth factor β type II receptor gene and microsatellite instability in gastric cancer
1996
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
2001
Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis
2000
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Eukaryotic mismatch repair: an update
1998
TGF-β receptor signaling
1997
Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer
1997
Replication errors: cha(lle)nging the genome
1998
Immunity, Inflammation, and Cancer
2010 Standout
A distinct molecular profile associated with mucinous epithelial ovarian cancer
2006
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
2004
Epigenetic gene regulation: Linking early developmental environment to adult disease
2006
Cancer-epigenetics comes of age
1999 Standout
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Milestones of Lynch syndrome: 1895–2015
2015
Hereditary Colorectal Cancer
2003 Standout
Genetic predisposition to colorectal cancer
2004
TGFβ in Cancer
2008 Standout
Eicosanoids and cancer
2010 Standout
Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling
2001
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
1998
Tumour budding in colorectal carcinoma
2006
Hereditary and Familial Colon Cancer
2010
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
1999
DNA mismatch repair and cancer
2001
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Mads and Smads in TGFβ signalling
1998
A census of human cancer genes
2004 Standout
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion
1998
Cancer-related inflammation
2008 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes
2013
Mechanisms and functions of DNA mismatch repair
2007
Mechanism of 5′-Directed Excision in Human Mismatch Repair
2003 StandoutNobel
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
1995 Standout
Analyses of microsatellite instability and the transforming growth factor‐β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features
1999
Tumor suppressor activity of the TGF-β pathway in human cancers
1996
Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
2001
Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
2003
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Tumor Metabolism of Lactate: The Influence and Therapeutic Potential for MCT and CD147 Regulation
2009
Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer.
2000
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.
2001
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer.
2003
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803
2009
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer
2009
CHK1 and CHK2 are differentially involved in mismatch repair–mediated 6-thioguanine-induced cell cycle checkpoint responses
2004
Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis.
1999
Repression of Prostaglandin Dehydrogenase by Epidermal Growth Factor and Snail Increases Prostaglandin E2 and Promotes Cancer Progression
2006
Quality Control by DNA Repair
1999 StandoutScienceNobel
Promoter Methylation in the Genesis of Gastrointestinal Cancer
2009
Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability.
2002
Histopathological Identification of Colon Cancer with Microsatellite Instability
2001
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells
1999
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells
1999
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer
2000
15-Hydroxyprostaglandin Dehydrogenase Is a Tumor Suppressor of Human Breast Cancer
2006
Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition
1997
Cancer Genome Landscapes
2013 StandoutScience
TGF-β signalling through the Smad pathway
1997
The latent transforming growth factor β binding protein (LTBP) family
2000
Neoantigens in cancer immunotherapy
2015 StandoutScience
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
2006
TbetaR-I(6A) is a candidate tumor susceptibility allele.
1999
Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.
2001
TGF-β and cancer
2005
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.
2002
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair
1997 StandoutNobel
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
1999
Dual Roles for Immunity in Gastrointestinal Cancers
2010
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Chemical Glycoproteomics
2016 StandoutNobel
Transforming growth factor β and cancer
1995
Works of James Lutterbaugh being referenced
Detection in Fecal DNA of Colon Cancer–Specific Methylation of the Nonexpressed Vimentin Gene
2005
A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.
1994
Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability
2000 StandoutNobel
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors
2009
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
2001
A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.
1995
Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.
1996 StandoutNobel
Silence of chromosomal amplifications in colon cancer.
2002
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.
1999
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers
2004
SLC5A8 , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
2003
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
2003